Rabdosia japonica glycoprotein XPS10-1, preparation method therefor and use of Rabdosia japonica glycoprotein XPS10-1

A kind of blue calyx tea vegetable and glycoprotein technology, which is applied in the fields of peptide preparation method, peptide/protein composition, chemical instruments and methods, etc., can solve the problems of tissue expression and substrate specificity differences, etc.

Active Publication Date: 2020-05-15
SHANGAI PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In mammals, reactions that occur by cleaving the 2,3-double bond of the indole ring of tryptophan are...

Method used

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  • Rabdosia japonica glycoprotein XPS10-1, preparation method therefor and use of Rabdosia japonica glycoprotein XPS10-1
  • Rabdosia japonica glycoprotein XPS10-1, preparation method therefor and use of Rabdosia japonica glycoprotein XPS10-1
  • Rabdosia japonica glycoprotein XPS10-1, preparation method therefor and use of Rabdosia japonica glycoprotein XPS10-1

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0034]Materials: 5.0 kg of blue calyx fragrant tea (batch number: SPHTCMXCC01) was obtained from Fengyang, Anhui (collected on November 20, 2015), DEAE Sepharose Fast Flow anion exchange resin and Superdex series molecular sieve gel columns were purchased from General Electric GE Healthcare; Pullulan P-82 standard set: P-5, P-10, P-20, P-50, P-100, P-200, P-400, P-800, Shodex; water is Ultrapure water (self-made in the laboratory); ascorbic acid, tryptophan, methylene blue, Catalase, dimethylaminobenzaldehyde, trichloroacetic acid, monosaccharide standard (D-glucose, D-arabinose, L-fucose , L-rhamnose, D-mannose, D-xylose, D-galactose) and trifluoroacetic acid were purchased from SIGMA Company; IDO enzyme was purchased from BPS Company, and 384-well compound plates were purchased from Nunc Company; Hela cells were purchased from Provided by Professor Li Erguang of Nanjing University, it was purchased from ATCC (product number CCL-2); DMEM, sodium pyruvate, L-Glutamine, non-ess...

preparation Embodiment 2

[0041] Taking different batches of S. japonica (batch number: SPHTCMXCC02), the extraction and separation and purification methods of Preparation Example 1 were repeated to obtain the S. sativa polysaccharide XPS10-1 of Preparation Example 2.

preparation Embodiment 3

[0043] Taking different batches of S. japonica (batch number: SPHTCMXCC03), the extraction and separation and purification methods of Preparation Example 1 were repeated to obtain the S. sativa polysaccharide XPS10-1 of Preparation Example 3.

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Abstract

The invention discloses a Rabdosia japonica glycoprotein XPS10-1. The Rabdosia japonica glycoprotein XPS10-1 comprises a polysaccharide and a protein, wherein monosaccharide composition of the polysaccharide comprises rhamnose and glucose, and amino acid composition of the protein comprises glutamic acid, serine and glycine. The invention further relates to a preparation method for the Rabdosia japonica glycoprotein XPS10-1 and use of the Rabdosia japonica glycoprotein XPS10-1. The Rabdosia japonica glycoprotein XPS10-1 can be used for preparing a tryptophan-2,3-dioxygenase inhibitor.

Description

technical field [0001] The invention relates to the field of extracting plants; in particular, it relates to a calyx calyx glycoprotein XPS10-1, its preparation method and application. Background technique [0002] Rabdosia japonica (Burm.f.) Hara is the original variety of Rabdosia japonica (Burm.f. Hara), which is a plant of the genus Isodon in the family Labiatae. Weifuchun Tablets is a pure traditional Chinese medicine preparation developed by Hu Qingyutang, a subsidiary of Shanghai Pharmaceutical Group. One of the main sources of medicinal materials of Weifuchun Zhongxiang tea. Weifuchun Tablets can invigorate the spleen and replenish qi, promote blood circulation and detoxify, and treat the early lesions of gastric cancer. . Weifuchun Tablet is the only national protected traditional Chinese medicine approved by the drug supervision department in China for the treatment of gastric precancerous lesions. In view of the good efficacy of Weifuchun Tablets, the material...

Claims

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Application Information

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IPC IPC(8): C07K14/415C07K1/36C07K1/30C07K1/18C07K1/16A61K38/16A61P35/00
CPCC07K14/415A61P35/00A61K38/00
Inventor 王辉俊刘彦君叶冠
Owner SHANGAI PHARMA GRP CO LTD
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