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Method for continuously preparing large-aperture nitrocellulose film

A nitrocellulose membrane and nitrocellulose technology are applied in the field of continuous preparation of large-pore nitrocellulose membranes, which can solve problems such as non-hydrophilicity, non-uniform membrane structure, and inability to make larger pore sizes, and achieve membrane protein adsorption. strong effect

Inactive Publication Date: 2020-05-15
上海市新亚净化器件厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some domestic products are not yet on the market, and they are immature, and there are many problems: the membrane is not strong, cannot make a larger pore size, the membrane structure is not uniform, not hydrophilic, the surface of the membrane is covered with dust, and the upper and lower sides are asymmetrical, etc.

Method used

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  • Method for continuously preparing large-aperture nitrocellulose film
  • Method for continuously preparing large-aperture nitrocellulose film
  • Method for continuously preparing large-aperture nitrocellulose film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of Large Pore Nitrocellulose Membrane

[0020] Step 1: Prepare the membrane slurry and prepare the membrane liquid: Add co-solvent, surfactant, water and polymer material nitrocellulose into the reaction kettle for mixing. After mixing for 5.5 hours, add solvent and dissolve and stir at room temperature for 24 hours; then After defoaming and filtering, a uniform casting solution is obtained for subsequent use; the casting solution described in step 1 has a mass composition of 20% of cosolvent, 5.5% of surfactant, 5.5% of water, 22.5% of nitrocellulose, and solvent 30%. The co-solvent is ethanol, the surfactant is PEG400, and the solvent is acetone.

[0021] Step 2: cast the casting solution through a casting machine; the casting height in step 2 is 550um.

[0022] Step 3: The cast wet film is evaporated and formed through the evaporation section; the evaporation conditions in Step 3 are wind speed 2.6m / s, air temperature 40°, and humidity 50%. ...

Embodiment 2

[0025] Embodiment two: the impact on membrane cleanliness

[0026] For the test results of formula and process on membrane cleanliness, see figure 1 , figure 2 , image 3 .

[0027] figure 1 It is the film pore diameter diagram at the production site according to the formula and process of the present application.

[0028] figure 2 It is the film pore diameter diagram of foreign brand A product.

[0029] image 3 It is the membrane pore diameter diagram of the domestic imitation product B.

[0030] The chart shows that the product is clean and has an open pore size diagram; the product of foreign brand A, due to the formula and process, the film produced has a spherical structure, which affects the performance of the film (adsorption, poor uniformity); domestic imitation products B. Due to the formula and process, the manufactured film has a lot of dust, which affects the performance of the film (adsorption, poor uniformity).

Embodiment 3

[0031] Example 3: Effects of Different Solvent Formulas and Component Proportions on Membrane Pore Size

[0032] The effects of different solvent formulations and composition ratios on the pore size of nitrocellulose membranes are shown in Table 1.

[0033] Table 1 Effects of different solvent formulations and composition ratios on the pore size of nitrocellulose membranes

[0034]

[0035] The above results show that, for nitrocellulose membranes, pore size has the greatest impact on performance.

[0036] Different nitrocellulose content and water content affect the pore size the most, and the final membrane performance is also different.

[0037] Co-solvents and solvents have little effect, choose the appropriate ones.

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Abstract

The invention discloses a method for continuously preparing a large-aperture nitrocellulose film, wherein the method comprises the steps: preparing a film solution: adding a cosolvent, a surfactant, water and a high polymer material nitrocellulose into a reaction kettle, mixing, after mixing, adding a solvent, and dissolving and stirring at normal temperature; defoaming and filtering to obtain a uniform film casting solution for later use; carrying out tape casting on the film casting solution through a tape casting machine; carrying out evaporation molding on the tape-casting wet film throughan evaporation section; and drying: drying in a drying section after film formation, and rolling after drying to obtain the large-aperture nitrocellulose film. The large-aperture nitrocellulose filmcan be continuously cast through continuous operation of the tape casting machine. According to the invention, the raw material ratio and the film forming process are improved, and the stable, uniformand firm nitrocellulose film can be produced. A stable and uniform film is formed by blending a film casting solution and controlling film forming conditions through the precise tape casting machine,cleaning and dust removal are not needed, and the film has natural permanent hydrophilicity and can be used for an in-vitro diagnosis test strip with high requirements.

Description

technical field [0001] The invention relates to the technical field of nitrocellulose membranes, in particular to a method for continuously preparing large-diameter nitrocellulose membranes. Background technique [0002] Nitrocellulose membrane, also known as NC membrane, is used as the carrier of C / T line in colloidal gold test paper, and it is also the place where the immune reaction occurs. So the NC membrane becomes the most important consumable in this experiment. Nitrocellulose membrane is currently the most widely used solid phase support. Nitrocellulose membrane can produce high-affinity adsorption with most negatively charged DNA, RNA and protein by virtue of its good hydrophobicity. After adsorption, it can be fixed by baking at 80°C or cross-linking by ultraviolet irradiation. Because of this performance, nitrocellulose membranes have been widely used in the fields of biochemistry and molecular biology, mainly in the fields of molecular hybridization, western b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08J9/28C08L1/18
CPCC08J5/18C08J9/28C08J2301/18C08J2201/0502C08J2205/044
Inventor 吴昊
Owner 上海市新亚净化器件厂
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