Lactoferritin-modified gold-bismuth selenide quantum dot material as well as preparation method and application thereof

A technology of quantum dot materials and milk protein, which is applied in the field of gold-bismuth selenide quantum dot materials and its preparation, can solve the problems of inability to penetrate the blood-brain barrier, large nanozyme particles, etc., and achieve excellent structural properties and hydrophilic properties , enhanced catalysis, good biocompatibility and hydrophilicity

Active Publication Date: 2020-05-19
SOUTH CHINA UNIV OF TECH
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Problems solved by technology

[0004] Aiming at the shortcomings of existing reports about the nanozyme particles for PD treatment, such as large particle size, inability to penetrate the blood-brain barrier (BBB), hydrophobicity, and easy aggregation in the liver, kidney and reticuloendothelial system, the primary task of the present invention is to provide a nanozyme with the ability to simulate Lactoferrin-modified gold-bismuth selenide quantum dot size nanomaterials (Lf-Au-Bi 2 Se 3 NDs)

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  • Lactoferritin-modified gold-bismuth selenide quantum dot material as well as preparation method and application thereof
  • Lactoferritin-modified gold-bismuth selenide quantum dot material as well as preparation method and application thereof
  • Lactoferritin-modified gold-bismuth selenide quantum dot material as well as preparation method and application thereof

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Embodiment 1

[0054] A preparation method of a ferlactin-modified gold-bismuth selenide quantum dot material, comprising the steps of:

[0055] (1) Take 35mg BiCl 3 Add it to 10mL HCl solution (concentration: 0.1mol / L) to prepare liquid A; take 11.8mg selenium powder, 660μL ethylenediamine and 220μL mercaptoethanol and mix them until there is no precipitation, then add 100mL BSA aqueous solution (concentration: 10mg / L mL), to prepare liquid B; add liquid A to liquid B (completely add within 1min) to obtain a mixed solution, the color of the solution turns black, the mixed solution is stirred for 2 hours and then centrifuged at 10000rpm for 10 minutes to get the supernatant. The above supernatant was dialyzed in pure water for 3 days, and the liquid was changed once every 4 hours to prepare BSA-Bi 2 Se 3 NDs solution;

[0056] (2) Take 10mL of the BSA-Bi described in step (1) 2 Se 3 NDs solution, after stirring, add 0.4mL concentration of 100mmol / L HAuCl 4 solution, stirred again for...

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Abstract

The invention discloses a lactoferritin-modified gold-bismuth selenide quantum dot material as well as a preparation method and application thereof. The prepration method comprises the following steps: (1) preparing a Bi2Se3 quantum dot solution by virtue of a sol-gel method; (2) carrying out in-situ reduction in the Bi2Se3 quantum dot solution, so as to generate an Au-Bi2Se3 quantum dot solution;and (3) modifying the surface with lactoferritin through Au-S bond reaction, so as to obtain the lactoferritin-modified gold-bismuth selenide quantum dot material. The Lf-Au-Bi2Se3 quantum dot material with high hydrophilcity and biocompatibility and good oxidation-reduction catalytic activity is prepared by virtue of the simple method and can be effectively applied to treatment of oxidative-stress-induced diseases such as neurodegenerative diseases and relevant inflammation.

Description

technical field [0001] The invention belongs to the preparation and application of quantum dot-sized nanoparticles, in particular to a gold-bismuth selenide quantum dot material modified by ferritin and its preparation method and application. Background technique [0002] Parkinson's disease (PD), also known as Parkinson's paralysis, is a neurodegenerative disease with unknown pathogenesis that occurs in the substantia nigra and nigrostriatum pathways. Due to the degeneration and loss of dopaminergic neurons in the brain of PD patients, the content of dopamine in the brain is significantly reduced, resulting in motor symptoms such as resting tremor, slowness of movement and muscle rigidity, and non-motor symptoms such as cognitive decline and emotional disturbance. . The risk of PD increases significantly with increasing age, and about 2% of the elderly over 60 years old will develop PD symptoms. Up to now, there is still no effective means for the treatment of PD, and it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/245A61K33/242A61K47/64A61K47/69A61P25/16A61P29/00A61P25/28A61P9/10
CPCA61K33/245A61K33/242A61K47/644A61K47/6929A61P25/16A61P29/00A61P25/28A61P9/10A61K2300/00
Inventor 李丽华韦小明彭明营杨中民
Owner SOUTH CHINA UNIV OF TECH
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