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A kind of hyaluronic acid sustained-release filler and its preparation method

A technology of hyaluronic acid and sodium hyaluronate, which is applied in the field of biomaterials and medical cosmetology, can solve problems such as easy formation of depressions or collapses, limited effect of collagen regeneration, and insufficient tissue support, so as to reduce costs and save time , the effect of reducing the number of injections

Active Publication Date: 2022-08-09
湖北翎美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, after this method is implanted, the surfactant is quickly absorbed, resulting in a decrease in the overall volume, and the surface area of ​​the solid microspheres is small, so the effect of stimulating collagen regeneration is limited, and multiple injections are required to maintain the effect, although prolonged Degradation time, but also increased treatment times and costs
Moreover, absorbable polymer materials are often isovolumetrically degraded. After the microspheres are completely degraded, gaps are formed at the injection site, and tissue cells have no time to grow in and are filled with interstitial fluid, resulting in insufficient support of the tissue at the filling site, and easy to form depressions or collapses.

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0037] There are many preparation methods for absorbable polymer porous microspheres, such as: double emulsion solvent evaporation method, suspension polymerization method, dispersion polymerization method, seed swelling method, microfluidic polymerization method, etc. are recorded. The invention adopts the disclosed double-emulsion solvent evaporation method to prepare porous microspheres.

[0038] The absorbable polymer porous microspheres can be PCL porous microspheres, or can be replaced by in vivo degradable or water-soluble polymer materials such as PLA, PLGA, PGA, PVA, P-TMC;

[0039] Only one type of cross-linked sodium hyaluronate and small molecular sodium hyaluronate can be added, and can be replaced by surfactants / density increasing agents with excellent water solubility and biocompatibility such as CMC, MC, and Tween;

[0040] PBS buffer can be replaced by normal saline, nutrients such as growth factors can be added, and anesthetic ingredients such as lidocaine c...

Embodiment 1

[0044] Example 1 Preparation of PCL microspheres and porous microspheres with a specific surface area of ​​318m 2 / g

Embodiment 2

[0045] Example 2 Preparation of PLA microspheres and porous microspheres with a specific surface area of ​​238m 2 / g

[0046] Embodiment 1:

[0047] PCL porous microspheres were used as absorbable polymer porous microspheres. The recipe is as follows:

[0048] The mass ratio is 30%, the particle size is 25~50 microns, the average pore size is 1 micron PCL porous microspheres, 1% cross-linked sodium hyaluronate, 2% small molecular sodium hyaluronate, 67% PBS buffer configuration into an injection filling product, the external sodium hyaluronate slowly degrades and forms collagen outside the microspheres, and then the sodium hyaluronate in the back hole slowly degrades, inducing collagen fibers to grow into the hole and form a scaffold-like structure, and finally PCL Porous microspheres degrade slowly. The small molecule sodium hyaluronate on the outside of the microspheres was completely degraded within 2 months, and the cross-linked sodium hyaluronate outside the pores of t...

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PUM

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Abstract

The existing absorbable injectable fillers in the field of medical cosmetology have a short maintenance time and cannot achieve a lasting filling effect. In the present invention, absorbable polymer porous microspheres are added to the original injection system to form a gradient degradation formula, and the micropore structure is filled with cross-linked sodium hyaluronate through a unique technology, and the cross-linked sodium hyaluronate in the micropores gradually During the degradation process, the microporous structure stimulates the tissue to produce collagen fibers to form a network structure, which can still play a filling effect after the polymer molecules are degraded.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to a novel sodium hyaluronate sustained-release filling material and a preparation method thereof, and also to the field of biological materials. Background technique [0002] Absorbable material is a polymer material that can be enzymatically or hydrolyzed into carbon dioxide and water by the human body and finally absorbed by the human body. Due to its excellent mechanical properties, easy processing performance and biocompatibility, it is widely used in the field of medicine. [0003] Hyaluronic acid and collagen are commonly used cosmetic injection filling materials. Although these two materials have a low probability of sensitization, they are widely used due to their functions such as absorbability, promotion of tissue repair, and excellent biocompatibility. Medical beauty industry. However, the absorption time of these two materials is short, and they can only last for abo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/50A61L27/56A61L27/58
CPCA61L27/20A61L27/18A61L27/50A61L27/56A61L27/58A61L2400/06C08L5/08C08L67/04
Inventor 陶翠娥
Owner 湖北翎美生物科技有限公司