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Novel fusarisetin herbicide derived from marine fungus, preparation method and application

A technology of marine fungi and herbicides, applied in the directions of herbicides and algicides, botany equipment and methods, biochemical equipment and methods, etc., which can solve the problems of undisclosed herbicide effects

Active Publication Date: 2022-04-29
TOBACCO RES INST CHIN AGRI SCI ACAD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fusarisetin compounds are a novel class of pentacyclic compounds containing decalin (6 / 6) and tricyclic (5 / 5 / 5), which were first reported by the Korean research group in 2011 and found that this type of compound has a strong tumor inhibitory effect Cell proliferation, but its herbicidal effect is not disclosed

Method used

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  • Novel fusarisetin herbicide derived from marine fungus, preparation method and application
  • Novel fusarisetin herbicide derived from marine fungus, preparation method and application
  • Novel fusarisetin herbicide derived from marine fungus, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0041] In this example, the structure of fusarisetins C–D (compound 1–2) was determined by NMR, mass spectrometry, infrared, ultraviolet, vibrational circular dichroism and X-Ray single crystal diffraction. Compound 2 is the first reported compound with 6 / 6 decahydronaphthalene The spectral data of fusarisetin C–D (compound 1–2), a fusarisetin compound chimeric with a 5 / 5 bicyclic ring, are as follows:

[0042] Fusarisetin C(1): colorless crystals; [α] 20 D +15.0 (concentration 0.25, methanol); UV (methanol) λ max (logε)202(3.42)nm; hydrogen spectrum and carbon spectrum data are shown in Table 1; high resolution mass spectrum m / z 372.1825[M -H] - (C 21 h 27 NO 5 Theoretical value, 372.1816);

[0043] Fusarisetin D(2): colorless oil; [α] 20 D -9.2 (concentration 0.13, methanol); UV (methanol) λ max (logε)200(3.19)nm; hydrogen spectrum and carbon spectrum data are shown in Table 2; high resolution mass spectrum m / z 390.2278[M+ H] + (C 22 h 32 NO 5 Theoretical value...

Embodiment 2

[0050] In this example, Amaranthus retroflexus and lettuce seeds were used as active targets to test their herbicidal activity. The results are shown in Table 3. The specific process is as follows:

[0051]First, sterilize the seeds of dicotyledonous plants such as Amaranthus retroflexus with 3%-5% sodium hypochlorite (NaClO) solution for 5-15 minutes, rinse with sterile water several times to remove sodium hypochlorite, and then dissolve the compound in methanol to prepare 0.2 mg / mL and 0.05 mg / mL solution, then put filter paper in a 24-well plate, add 200 μL compound solution to each well, after the solvent evaporates, add 200 μL sterile water to each well, seal it and put it in a light incubator at 28 ° C for 12 h Light, 12h dark culture, count germination rate and rhizome growth after 4 days.

[0052] Table 3: Compounds 1–4 (200 μg / mL) inhibited the growth of Amaranthus retroflexus and lettuce root shoots

[0053]

[0054] Among them, "gp" glyphosate. Length<2.0mm is ...

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Abstract

The invention belongs to the technical field of herbicides, and relates to a fusarisetin herbicide derived from a marine fungus, a preparation method and an application. Two fusarisetin compounds fusarisetins C and fusarisetins D with novel structures are isolated and identified from the marine fungus Fusarisetin, wherein fusarisetin D is the first fusarisetin compound with 6 / 6 decahydronaphthalene and 5 / 5 bicyclic chimerism; at the same time, new compounds and known compounds fusarisetins A and fusarisetins B were found to have herbicidal activity on dicotyledonous plants such as Amaranth retroflexus; The seed germination and rhizome growth of dicotyledonous plants such as amaranth have obvious inhibitory effect, and for transplanted crops, it has no obvious toxic and side effects on seedlings.

Description

Technical field: [0001] The invention belongs to the technical field of herbicides, and relates to a fusarisetin herbicide derived from marine fungi, a preparation method and an application. Background technique: [0002] my country is a large agricultural country, and crop diseases, insect pests and weeds seriously endanger agricultural production and cause huge economic losses every year. Although traditional chemical pesticides can reduce these hazards to a certain extent, problems such as environmental pollution, food safety and pathogen resistance are becoming more and more serious. Especially for herbicides, the existing herbicides are highly toxic, seriously pollute the environment, and can cause phytotoxicity to crops. Therefore, it is imminent to develop new biological herbicides. Most of the existing biological herbicides are compound biological herbicides. For example, CN201310367156.9 discloses a compound biological herbicide and its use method, which is a compo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/107C07D209/96A01N43/90A01N43/38A01P13/00C12P17/18C12P17/10C12R1/77
CPCC07D491/107C07D209/96A01N43/90A01N43/38C12P17/18C12P17/10C07B2200/13
Inventor 赵栋霖张成省芶剑渝刘明宏韩小斌刘京彭玉龙李义强丁飞张之矾张翔
Owner TOBACCO RES INST CHIN AGRI SCI ACAD
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