pH-sensitive gel microcapsule and preparation method therefor

Abstract

The invention discloses a pH-sensitive gel microcapsule and a preparation method therefor. The pH-sensitive gel microcapsule comprises the following components in mass percent: 1%-50% of fat-soluble nutrients, 0.01%-2% of antioxidant, 1%-20% of alginate, 1%-10% of calcium salt having an emulsifying action, 0.1%-5% of cellulose derivative with amino groups, 0.1%-2% of stabilizer and 11%-96.79% of auxiliary wall materials; and the w / v concentration of a solution of the cellulose derivative with the amino groups is 0.1%-6%. According to the method, the fat-soluble nutrients are evenly dispersed,and then are embedded in materials through a special embedding combined material and an embedding technology; due to pH sensitivity generated by interaction between the materials and the deep embedding technology, the effect that the nutrients are reduced in release in gastric juice to the greatest extent, but are rapidly released in the small intestine can be achieved, and the human bioavailability is improved.

Description

technical field [0001] The invention relates to the field of capsules, in particular to a pH-sensitive gel microcapsule and a preparation method thereof. Background technique [0002] With the development of modern society, the fast-paced life makes people's diet more and more irregular. Unreasonable diet leads to insufficient intake of various nutrients needed by the human body, which leads to the lack of relevant essential nutrients. Long-term intake Insufficient nutrition will lead to malnutrition, affect children's intellectual growth and development, human body's ability to resist diseases, and decline in labor, work, and learning abilities. Therefore, people are paying more and more attention to the intake of nutrients through nutrition fortifiers and other methods, and microcapsules are currently a relatively common method for preparing nutrition fortifiers. [0003] The human stomach is a very important digestive organ. However, nutrients such as vitamins cannot be ...

AI Technical Summary

Problems solved by technology

Although the fat-soluble nutrients have solved the problem of water solubility through microcapsule embedding, the microcapsule products prepared by domestic and foreign manufacturers have not considered that the nutrients have already begun to be released in the esophagus and stomach after entering the human body, and the strong acid in the stomach Decomposed and inactivated under the action, making it difficult for the released nutrients to enter the small intestine to be effectively absorbed and utilized

Chinese patent application CN101902922A uses hydrophilic colloidal caseinate to simply embed vitamin D3, β-carotene and other fat-soluble nutrients into microcapsules to enhance the chemical stability of active substances during processing, storage and transportation However, it does not take into account that vitamin D3, β-carotene and other substances enter the human body and are quickly released in the stomach. They are no longer chemically stable in contact with gastric acid, and the active substances are inactivated and cannot be absorbed by the human body.

[0004] And Chinese patent application CN102550817A provides a kind of high stability, the preparation method of functional oil microcapsule with immobilized protein film, yet the immobilized protein film formed by embedding in this way has indeed improved the stability of microcapsules water-soluble However, it ignores the initial hydrolysis of protein under the action of strong acid in the human stomach, which leads to the destruction of the dense protein film, the loss of fat-soluble nutrients and the reduction of bioavailability

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