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A kind of method for extracting shikimic acid and quinic acid in ginkgo biloba

A technology of shikimic acid and ginkgo biloba, which is applied in the separation/purification of carboxylic acid compounds, bulk chemical production, organic chemistry, etc., can solve the problems of large amount of wastewater treatment, environmental pollution, cumbersome operation, etc., to reduce the amount of sewage, Effect of reducing environmental pollution and reducing solvent consumption

Active Publication Date: 2022-06-07
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of method of developing shikimic acid and quinic acid in Ginkgo biloba, to overcome problems such as long time consumption, large amount of waste water treatment, environmental pollution, complicated operation that exist in the above-mentioned method, the whole process route of the present invention except In addition to the separation and purification of the above two organic acids, it also realizes the enrichment and purification of multiple species at the same time, maximizes the utilization of resources as much as possible, greatly reduces product costs, reduces energy consumption and sewage volume, and increases production capacity

Method used

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  • A kind of method for extracting shikimic acid and quinic acid in ginkgo biloba
  • A kind of method for extracting shikimic acid and quinic acid in ginkgo biloba
  • A kind of method for extracting shikimic acid and quinic acid in ginkgo biloba

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Effect test

Embodiment 1

[0055] 5 kg of fresh raw materials of ginkgo leaves were cut into pieces, added to the extraction kettle, 5L pH=8 acetone solution was used as the entrainer, the pressure of the extraction kettle was 28MPa, the extraction temperature was 55°C, the extraction time was 1.5h, the pressure of the No. 45°C, the pressure of No. 2 separation kettle is 6MPa, and the temperature is 40°C. The extract (A) is obtained from the No. 1 separation kettle, and the extract (A) is rich in chlorophyll, and the purification of product I chlorophyll can be continued. The extraction residue (B) is obtained in the extraction kettle. The extraction residue (B) is digested with alkaline water to inactivate the enzyme. For example, 5 times the amount of sodium bicarbonate aqueous solution can be digested at 100 ° C, taken out after inactivation of the enzyme, extracted twice with ethanol, combined with the extract, concentrated and adjusted to neutrality. Filter the supernatant. Polyamide is added to ...

Embodiment 2

[0060] 5 kg of fresh raw materials of ginkgo leaves were cut into pieces, added to the extraction kettle, 10L pH=8.5 acetone solution was used as the entrainer, the extraction kettle pressure was 30MPa, the extraction kettle temperature was 50°C, the extraction time was 2h, the No. 1 separation kettle pressure was 8MPa, and the temperature 40°C, the pressure of No. 2 separation kettle is 6MPa, and the temperature is 40°C. The extract (A) is obtained from the No. 1 separation kettle, and the extract (A) is rich in chlorophyll, and the purification of product I chlorophyll can be continued. The extraction residue (B) is obtained in the extraction kettle. The extraction residue (B) was digested with alkaline water to kill the enzyme. After inactivating the enzyme, take out and extract twice with ethanol, combine the extracts, concentrate the extracts to neutrality, and filter to obtain the supernatant. Polyamide is added to the supernatant [the mass ratio of supernatant and pol...

Embodiment 3

[0063] 5 kg of fresh raw materials of Ginkgo biloba leaves were cut into pieces, added to the extraction kettle, 8L pH=8 acetone solution was used as the entrainer, the pressure of the extraction kettle was 28MPa, the extraction temperature was 50°C, the extraction time was 1.5h, the pressure of the No. 45°C, the pressure of No. 2 separation kettle is 6MPa, and the temperature is 40°C. The extract (A) is obtained from the No. 1 separation kettle, and the extract (A) is rich in chlorophyll, and the purification of product I chlorophyll can be continued. The extraction residue (B) is obtained in the extraction kettle. The extraction residue (B) was digested with alkaline water to kill the enzyme. After inactivating the enzyme, take out and extract twice with ethanol, combine the extracts, concentrate the extracts to neutrality, and filter to obtain the supernatant. Polyamide is added to the supernatant [the mass ratio of the supernatant and polyamide is 3:1] to obtain a filtra...

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Abstract

The invention belongs to the field of extraction and separation of organic acids, and relates to a method for extracting shikimic acid and quinic acid in ginkgo leaves, which overcomes the problems of long time consumption, large amount of wastewater treatment, environmental pollution, cumbersome operation and the like in the existing methods. The chemical properties of the components in Ginkgo biloba are combined with carbon dioxide supercritical extraction-extraction-membrane filtration-electrodialysis-crystallization methods, and strive to maximize the development of various active components in Ginkgo biloba on the premise of commercial value. In addition to shikimic acid and quinic acid, it also includes chlorophyll, ginkgo flavonoids, ginkgolides, ginkgo polysaccharides, etc., and the shikimic acid and quinic acid products are finally separated, and the contents are respectively greater than 98%.

Description

technical field [0001] The invention belongs to the field of organic acid extraction and separation, relates to a method for developing organic acids in ginkgo leaves, and in particular relates to a method for extracting and separating shikimic acid and quinic acid from ginkgo leaves. Background technique [0002] Ginkgo has been used for medicinal purposes for more than 600 years, and its efficacy was first recorded in "Shen Nong's Materia Medica". Traditional medicine believes that Ginkgo biloba and fruit are sweet, bitter, astringent, and flat in nature. Hangover and other effects; Ginkgo biloba seed coat is sweet, warm in nature, and has the effect of benefiting qi and tonifying deficiency. The main chemical constituents of Ginkgo biloba are flavonoids, terpenes, organic acids, phenolic acids, and polysaccharides. [0003] The organic acids in Ginkgo biloba are mainly as follows: D-gluconic acid, shikimic acid, 6-hydroxykynurenic acid, quinic acid, etc. [0004] Ginkg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/42C07D311/40C07D487/22C07D493/22C08B37/00C07C62/32C07C62/04
CPCC07C51/42C07D487/22C07D311/40C07D493/22C08B37/0003C07C2601/14C07C2601/16C07C62/32C07C62/04Y02P20/54
Inventor 王晓莹程闪肖红张瑜
Owner SHAANXI JIAHE PHYTOCHEM