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Nanogel with antibacterial and repairing properties as well as preparation method and application thereof

A nano-gel and performance technology, applied in medical science, bandages, etc., can solve the problems of poor antibacterial activity, achieve high antibacterial activity, promote healing, and simple preparation process

Active Publication Date: 2020-06-05
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it should be noted that antibacterial hydrogels based on quaternary ammonium CS polymers generally have poor antibacterial activity in vivo, requiring repeated treatments or combined use with excess active ingredients (such as antibiotics) to improve antibacterial efficiency.

Method used

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  • Nanogel with antibacterial and repairing properties as well as preparation method and application thereof
  • Nanogel with antibacterial and repairing properties as well as preparation method and application thereof
  • Nanogel with antibacterial and repairing properties as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A method for preparing a nanogel with antibacterial and repairing properties, comprising the steps of:

[0057] 1) Polymerization: fully dissolve PCEC, QAS and 1,6-hexamethylene diisocyanate in N,N-dimethylformamide at a molar ratio of 1:1:2, and add catalyst dibutyltin dilaurate to it , heated up to 50°C, and reacted at this temperature for 24 hours to obtain a PCEC-QAS copolymer; the reaction process, such as figure 1 shown;

[0058] 2) Crude extraction: add the PCEC-QAS copolymer to petroleum ether for crude extraction, collect the precipitate, suction filter, wash 3 times, and vacuum dry to obtain a white solid PCEC-QAS crude product;

[0059] 3) Refining: Dissolve the crude product of PCEC-QAS in N,N-dimethylformamide solvent, add dropwise to ultrapure water and dialyze for 24 hours, then freeze-dry the dialyzed product to obtain PCEC-QAS nano frozen dry powder, by NMR 1 HNMP, infrared spectroscopy and other methods to detect its chemical structure;

[0060] 1...

Embodiment 2

[0096] A method for preparing a nanogel with antibacterial and repairing properties, comprising the steps of:

[0097] 1) Polymerization: fully dissolve PCEC, QAS and 1,6-hexamethylene diisocyanate in dimethyl sulfoxide at a molar ratio of 1:0.5:1.5, and add the catalyst dibutyltin dilaurate to it, and heat up to 40°C, react at this temperature for 30 hours to obtain PCEC-QAS copolymer;

[0098] 2) Rough extraction: adding PCEC-QAS copolymer to benzene for crude extraction, collecting the precipitate, suction filtration, washing 3 times, and vacuum drying to obtain a white solid PCEC-QAS crude product;

[0099] 3) Refining: The crude product of PCEC-QAS was dissolved in N,N-dimethylformamide solvent, and added dropwise to ultrapure water, then dialyzed for 12 hours, and then, the dialyzed product was freeze-dried to obtain PCEC-QAS Nano freeze-dried powder;

[0100] 4) Preparation of hydrogel

[0101] Weigh an appropriate amount of PCEC-QAS freeze-dried powder, dissolve it ...

Embodiment 3

[0103] A method for preparing a nanogel with antibacterial and repairing properties, comprising the steps of:

[0104] 1) Polymerization: Fully dissolve PCEC, QAS and 1,6-hexamethylene diisocyanate in propylene glycol at a molar ratio of 1:10:11, and add the catalyst dibutyltin dilaurate to it, heat up to 70°C, and Reaction at this temperature for 48 hours to obtain PCEC-QAS copolymer;

[0105] 2) Crude extraction: adding the PCEC-QAS copolymer to diethyl ether for crude extraction, collecting the precipitate, suction filtration, washing 3 times, and vacuum drying to obtain a white solid PCEC-QAS crude product;

[0106] 3) Refining: The crude product of PCEC-QAS was dissolved in N,N-dimethylformamide solvent, and added dropwise to ultrapure water, then dialyzed for 72 hours, and then, the dialyzed product was freeze-dried to obtain PCEC-QAS Nano freeze-dried powder;

[0107] 4) Preparation of hydrogel

[0108] Weigh an appropriate amount of PCEC-QAS freeze-dried powder, dis...

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Abstract

The invention discloses a nanogel with antibacterial and repairing properties, which comprises the following raw materials: PCEC, QAS and diisocyanate in a molar ratio of 1:(0.5-10):(1.5-11). The preparation method comprises the following steps: polymerization, crude extraction, refining and gel preparation. With PCEC and QAS as raw materials to prepare hydrogel, the hydrogel has good antibacterial performance on gram-positive bacteria, gram-negative bacteria, fungi and other microorganisms, and is expected to be used as a spectrum antibacterial dressing; in addition, the preparation process is simple, degradable and good in biocompatibility, and has a good commercial prospect.

Description

technical field [0001] The invention relates to the technical field of research and development of new biomedical materials and related medical devices, and more specifically relates to a nanogel with antibacterial and repairing properties and its preparation method and application. Background technique [0002] With the implementation of the Healthy China 2030 strategy and the economic transformation led by the national health industry, people are paying more and more attention to health-related issues. Related medical problems caused by bacterial infection have increasingly become a hot spot in clinical research. Infection is one of the common serious complications of trauma and other open wounds, and the difficult wound healing caused by bacterial infection is a major clinical problem. Bacterial resistance caused by overuse of antibiotics has brought great difficulties to the treatment of infections. With the rapid development of materials science and engineering techno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/42C08G18/32C08J3/075A61L26/00C08L75/06
CPCA61L26/0019A61L26/0061A61L26/008A61L26/0085A61L26/009C08G18/3868C08G18/4277C08G18/6633C08J3/075C08J2375/06C08L75/06
Inventor 刘文帅王伟伟孔德领黄平升张闯年
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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