Preparation method of medicinal magnesium sulfate

A technology of magnesium sulfate and sulfuric acid, which is applied in the direction of magnesium sulfate, antipyretics, anti-infectives, etc., can solve the problems of potential safety hazards, cumbersome preparation process, and failure to solve calcium impurities in magnesium sulfate, and achieve mild reaction conditions and easy operation Effects in simple steps

Inactive Publication Date: 2020-06-12
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation process of the method involved in the above-mentioned patent documents is cumbersome, and does not solve the problem of calcium impurities in magnesium sulfate
Chinese patent (CN103058235) uses hydrofluoric acid to precipitate impurity calcium ions in magnesium sulfate to produce high-purity magnesium sulfate, but hydrofluoric acid belongs to a kind of highly corrosive substance, which is relatively harmful to metal equipment, enamel equipment, transmission pipelines, etc. High corrosiveness and potential safety hazards

Method used

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  • Preparation method of medicinal magnesium sulfate

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Experimental program
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Effect test

Embodiment 1

[0016] Add 50 liters of deionized water into the reaction kettle, start stirring, add 10 kg of industrial magnesium oxide, after the material is stirred and dispersed evenly, slowly add concentrated sulfuric acid dropwise, control the pH value of the reaction system to 5-6, and stop adding sulfuric acid. Heat the reaction to 70-80°C, add 0.17 kg of oxalic acid, 0.1 kg of activated carbon, stir for 0.5-1 hour, filter while hot, transfer the filtrate to a crystallization tank, stir and crystallize at 20-30°C, centrifuge, rinse with a small amount of water , dried to obtain medicinal magnesium sulfate.

Embodiment 2

[0018] Add 100 liters of deionized water into the reaction kettle, start stirring, add 20 kg of industrial magnesium oxide, after the material is stirred and dispersed evenly, slowly add concentrated sulfuric acid dropwise, control the pH value of the reaction system to 5-6, and stop adding sulfuric acid. Heat the reaction kettle to 60-70°C, add 0.6kg oxalic acid and 0.2kg activated carbon, stir for 1-2 hours, filter while hot, transfer the filtrate to a crystallization tank, stir and crystallize at 20-30°C, centrifuge, and shower with a small amount of water Wash and dry to obtain medicinal magnesium sulfate.

Embodiment 3

[0020] Add 100 liters of deionized water into the reaction kettle, start stirring, add 20 kg of industrial magnesium oxide, after the material is stirred and dispersed evenly, slowly add concentrated sulfuric acid dropwise, control the pH value of the reaction system to 5-6, and stop adding sulfuric acid. Heat the reaction kettle to 50-60°C, add 0.9kg oxalic acid, 0.2kg activated carbon, stir for 1-2 hours, filter while hot, transfer the filtrate to a crystallization tank, stir and crystallize at 20-30°C, centrifuge, and shower with a small amount of water Wash and dry to obtain medicinal magnesium sulfate.

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Abstract

The invention discloses a preparation method of medicinal magnesium sulfate. According to the method, magnesium oxide and sulfuric acid are used as raw materials and oxalic acid is used as an impurityremoval reagent, so that the magnesium sulfate is prepared through one-step reaction, and the calcium ion content in the product meets the specification. The preparation method disclosed by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple operation and good reproducibility, and the obtained product has very high yield and purity, and is suitable for industrial production requirements.

Description

technical field [0001] The invention belongs to the field of food and medicine, and in particular relates to a method for preparing medicinal magnesium sulfate. Background technique [0002] Magnesium sulfate usually refers to magnesium sulfate heptahydrate, also known as sulfur bitter, bitter salt, epsom salt, epsom salt. It can be widely used in food, medicine and other fields. In the field of food, magnesium sulfate is used in the production of monosodium glutamate, yeast, salt and other products; it can also be used as a food additive as a nutritional supplement. In the field of medicine, magnesium sulfate can be used for catharsis, detoxification, gallbladder, and cholecystitis and biliary colic. Hyperlipidemia, congestive mental failure, angina pectoris, myocardial infarction; it can be used for sedation, anticonvulsant and lowering of blood pressure; intravenous injection or infusion can treat biliary ascariasis, tetanus and threatened premature labor in pregnancy, ...

Claims

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Application Information

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IPC IPC(8): C01F5/40A61K33/06A61P39/02A61P1/16A61P29/00A61P9/06A61P3/06A61P9/04A61P9/10A61P25/20A61P9/12A61P25/08A61P33/10A61P21/02A61P15/06
CPCC01F5/40A61K33/06A61P39/02A61P1/16A61P29/00A61P9/06A61P3/06A61P9/04A61P9/10A61P25/20A61P9/12A61P25/08A61P33/10A61P21/02A61P15/06C01P2006/80
Inventor 赵思太任业明马新成邓玉晓张宁张宗磊冯光玲孔祥雨杨利崔新强刘文涛刘宜辉龚艳艳樊志萍孙晋瑞段崇刚
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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