Paracetamol tablet and preparation method thereof
A technology for acetaminophen tablets and acetaminophen, which is applied to the field of acetaminophen tablets and their preparation, can solve problems such as splits, and achieve the effects of high dissolution rate, improved appearance qualification rate, and good stability
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Embodiment 1
[0019] Example 1: To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), the following components were used:
[0020]
[0021] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III: Slowly add the mixture II...
Embodiment 2
[0022] Example 2: To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), use the following components
[0023]
[0024] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III; slowly add the mixture III to th...
Embodiment 3
[0025] Example 3 To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), use the following components
[0026]
[0027] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III; slowly add the mixture III to the...
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