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Preparation method of animal compound amino acid injection

A compound amino acid and injection technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve problems such as poor stability of amino acids

Active Publication Date: 2021-04-30
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a preparation method of animal compound amino acid injection, to solve the problem of poor stability of each amino acid in animal injection

Method used

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  • Preparation method of animal compound amino acid injection
  • Preparation method of animal compound amino acid injection
  • Preparation method of animal compound amino acid injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of embodiment 1 livestock compound amino acid injection

[0038] The present embodiment is the preparation method of animal compound amino acid injection, with 1m 3 Taking compound injection for livestock as an example, its specific preparation method includes the following steps carried out in sequence:

[0039] Step 1) Prepare base fluid:

[0040] Take 1000L water for injection, boil and sterilize for 40 minutes, and set aside;

[0041] Take by weighing 0.89kg sodium bisulfite and 0.10kg edetate disodium, set aside;

[0042] Take 600L of water for injection and place it in the concentrated preparation tank, and inject CO 2 Air flow, while controlling the water temperature at 95°C, in CO 2 Add 0.89 kg of disodium ethylenediamine tetraacetate and 0.10 kg of sodium bisulfite under the protection of air flow, stir to dissolve completely, and prepare base liquid A.

[0043] Among them, sodium bisulfite has the effect of preventing the oxidation ...

Embodiment 2～6

[0062] The preparation method of embodiment 2~6 livestock compound amino acid injection

[0063] Examples 2-6 are respectively a preparation method of a compound amino acid injection for livestock, which is basically the same as the preparation method in Example 1, except that the amount of each amino acid raw material and the parameters in each step are different. Taking 1000L compound injection for livestock as an example, the consumption of making its specific active ingredient raw materials is weighed according to the consumption of each active ingredient raw material provided in Table 1 respectively, and the specific active ingredient raw materials are shown in Table 1; Each process parameter in the step, concrete parameter sees table 2:

[0064] Table 1 The dosage list of each active ingredient raw material

[0065]

[0066]

[0067] The list of each process parameter of table 2 embodiment 2~6

[0068]

[0069] The specific situation of each amino acid content...

Embodiment 7

[0075] The quality detection of embodiment 7 compound amino acid injections for livestock

[0076] In this example, the compound amino acid injection for animals prepared by the method in Example 1 was used for quality inspection. The specific detection method is as follows:

[0077] The accelerated test is placed under the conditions of temperature 40±2°C and relative humidity 75±5% for 6 months, and samples are taken at the end of the 0th month, 1st month, 2nd month, 3rd month and 6th month during the test period. The quality standards of WS1~(X~324)~2003Z of "Drug Standards of the State Food and Drug Administration" were tested, and the specific test results are shown in Table 4:

[0078] Table 4 Quality inspection results of compound amino acid injection for livestock

[0079]

[0080]

[0081] As can be seen from Table 4, the animal compound amino acid injection prepared in Example 1 is through the accelerated test, and each index has no obvious change, and the sa...

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Abstract

The invention discloses a preparation method of animal compound amino acid injection, which belongs to the technical field of animal husbandry and veterinary medicine. 2 Add the antioxidant disodium ethylenediamine tetraacetate and the antioxidant sodium bisulfite at 75-95°C under airflow protection; CO 2 Add 15 kinds of amino acids at 70~100℃ under gas protection, then add tryptophan, tyrosine, cysteine ​​hydrochloride at 60~70℃, and finally add γ-aminobutyric acid at 20~35℃ to adjust the pH Value, decolorization and other steps solve the problem of poor stability of animal amino acid injection. The present invention adopts step-by-step feed preparation to prepare livestock amino acid injection, and in CO 2 Adding tryptophan, tyrosine, and cysteine ​​hydrochloride at the same time under protection at 60-70°C can effectively improve the stability of tryptophan and tyrosine, and prevent the oxidation of tryptophan and tyrosine; The injection is suitable for body repair during the treatment of livestock animal diseases and the recovery period after the disease.

Description

technical field [0001] The invention belongs to the technical field of animal husbandry and veterinary medicine, and relates to a preparation method of animal injection, in particular to a preparation method of animal compound amino acid injection. Background technique [0002] Currently, glucose injection, sodium chloride injection and glucose sodium chloride injection are mainly used as replenishing fluids for enhancing animal physical fitness. These three injections are mainly used to replenish water and energy, and to regulate the balance of electrolytes in the body, but they cannot improve the nutritional status of the animal body and supplement the amino acids required by the animal body, and thus cannot effectively regulate the feed intake of the animal, especially for the weak, Animals during the disease period need to supplement amino acids to improve nutrition, thereby promoting the recovery of animals. [0003] Generally weak, sick animals mostly show symptoms su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/18A61K47/02A61K31/4172A61K31/401A61K31/198A61K31/405A61P3/02
CPCA61K9/0019A61K9/08A61K31/198A61K31/401A61K31/405A61K31/4172A61K47/02A61K47/183A61P3/02A61K2300/00
Inventor 李凤英陈淑芳赵素娟郭艳玉李艳王伟光邢江盼
Owner HEBEI KEXING PHARMA
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