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Wound dressing with antibacterial and bacterial warning functions and preparation method thereof

A wound dressing and functional technology, applied in dressings, non-adhesive dressings, bandages, etc., can solve the problems of complex preparation process and high production cost, and achieve the effect of simple process steps, strong peeling effect, and stable chemical properties

Active Publication Date: 2022-04-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of dressing is convenient to judge whether the dressing is bacteria-carrying, because the dressing is based on hydrogel, its surface is covered with a layer of porous sensor array prepared by 3D printing technology. The porous sensor array is made of color-changing alginate fiber. Composition, changing the color of the dressing by doping the pH-sensitive dye mesoporous resin beads in the color-changing alginate fiber, and using silver ions as the antibacterial agent, so not only the preparation process is complicated, the production cost is high, but there are also side effects caused by silver ions

Method used

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  • Wound dressing with antibacterial and bacterial warning functions and preparation method thereof
  • Wound dressing with antibacterial and bacterial warning functions and preparation method thereof
  • Wound dressing with antibacterial and bacterial warning functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The steps of the present embodiment are as follows:

[0033] (1) Prepare polyvinyl alcohol foam with dense top surface and porous structure in the lower part

[0034] The polyvinyl alcohol was dissolved in 90 ° C deionized water, and then cooled to room temperature, and then added formaldehyde and concentrated sulfuric acid and mixed to form a reaction liquid, and then the reaction liquid was heated in an oven to 80 ° C for 2h, to obtain a dense top surface, the lower part is a porous structure of the polyvinyl alcohol foam, the reaction liquid, the concentration of polyvinyl alcohol is 80g / L, the ratio of the mass of polyvinyl alcohol to the volume of formaldehyde is 1:0.6, the ratio of the mass of polyvinyl alcohol to the volume of concentrated sulfuric acid is 1:0. 13, the mass unit of polyvinyl alcohol is g, and the volume unit of formaldehyde and concentrated sulfuric acid is mL;

[0035] (2) Soak and dry

[0036] The polyvinyl alcohol foam obtained in step (1) was r...

Embodiment 2

[0046] The steps of the present embodiment are as follows:

[0047] (1) Prepare polyvinyl alcohol foam with dense top surface and porous structure in the lower part

[0048] The polyvinyl alcohol was dissolved in 100 ° C deionized water, and then cooled to room temperature, and then added butyral and concentrated sulfuric acid and mixed to form a reaction liquid, and then the reaction liquid was heated in an oven to 90 ° C insulation for 1h, to obtain a dense top surface, the lower part is a porous structure of the polyvinyl alcohol foam, the reaction liquid, the concentration of polyvinyl alcohol is 100g / L, the ratio of the mass of polyvinyl alcohol to the volume of butyral is 1:0.5, the ratio of the mass of polyvinyl alcohol to the volume of concentrated sulfuric acid is 1:0. 05, the mass unit of polyvinyl alcohol is g, and the volume unit of butyral and concentrated sulfuric acid is mL;

[0049] (2) Soak and dry

[0050]The polyvinyl alcohol foam obtained in step (1) was rep...

Embodiment 3

[0056] The steps of the present embodiment are as follows:

[0057] (1) Prepare polyvinyl alcohol foam with dense top surface and porous structure in the lower part

[0058] The polyvinyl alcohol was dissolved in 120 ° C deionized water, and then cooled to room temperature, and then added butyral and concentrated sulfuric acid and mixed to form a reaction liquid, and then the reaction liquid was heated in an oven to 80 ° C for 2h, to obtain a dense top surface, the lower part is a porous structure of the polyvinyl alcohol foam, the reaction solution, the concentration of polyvinyl alcohol is 50g / L, the mass of polyvinyl alcohol and the volume ratio of butyral is 1:1, the ratio of the mass of polyvinyl alcohol to the volume of concentrated sulfuric acid is 1:0. 04, the mass unit of polyvinyl alcohol is g, and the volume unit of butyral and concentrated sulfuric acid is mL;

[0059] (2) Soak and dry

[0060] The polyvinyl alcohol foam obtained in step (1) was repeatedly cleaned wi...

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Abstract

The wound dressing with both antibacterial and bacterial warning functions of the present invention is composed of a wound contact layer, an intermediate moisture-absorbing layer and an external protective layer. The wound contact layer is a fibrous film with blood coagulation function, and the intermediate moisture-absorbing layer contains Polyvinyl alcohol porous foam with antibacterial agent, the outer protective layer is polyvinyl alcohol dense foam containing methylene blue and antibacterial agent, the middle moisture absorption layer and the outer protective layer are an integrated structure, and the wound contact layer and the middle moisture absorption layer are combined together , the antibacterial agent is a quaternary ammonium salt or a quaternary phosphonium salt. When the dressing of the present invention is free of bacteria, the middle hygroscopic layer and the outer protective layer are blue, and gradually change from blue to white if bacteria grow. The steps of the preparation method of the dressing are as follows: (1) preparing a polyvinyl alcohol foam with a dense top surface and a porous structure in the lower part, (2) soaking and drying, (3) preparing a fibrous film with blood coagulation function, (4) cutting, Assembly, packaging and sterilization.

Description

Technical field [0001] The present invention belongs to the field of wound dressings, relates to wound dressings having both antibacterial and bacteriological warning functions and preparation methods thereof. Background [0002] Skin trauma is a common type of injury, and dressings are medical materials used for skin trauma treatment and protection. At present, although there are many kinds of wound dressings on the market, there are mainly two types. One type is a dressing with coagulation, hygroscopicity, and promotes wound healing, and the other type is to add an antibacterial dressing on the basis of the above function, but the dressing with antibacterial function is mainly by adding silver ions to give the dressing good antibacterial properties (such as the Aquacel Ag dressing produced by ConvaTec), and the silver ion has a certain cytotoxicity, which will cause adverse effects on the injured person, and the addition of silver ions will increase the preparation cost of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/44A61L15/46A61L15/24A61L15/20A61F13/00
CPCA61L15/425A61L15/24A61L15/20A61L15/46A61L15/44A61F13/00059A61F13/00063A61L2300/208A61L2300/216A61L2300/404A61L2300/418A61F13/01029C08L29/04
Inventor 张利何苗苗郭涛
Owner SICHUAN UNIV
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