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Patch cataplasm for dispersing blood stasis and warming channels and preparation method thereof

A warming and chemical technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, non-effective ingredients of polymer compounds, etc., can solve the problems of small drug load, allergies, poor transdermal performance, etc., and achieve portable use Convenience, long-term drug release, and strong sustained-release effect

Inactive Publication Date: 2020-07-03
上海市浦东新区中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional plasters (soft plasters, black plasters) are all based on fat-soluble materials, which have serious defects in application: small drug load, poor transdermal performance, allergies, rashes, hair sticking, clothing contamination, etc.
[0005] However, there is no cataplasm for dysmenorrhea in the prior art, because many women experience pain in the lower abdomen, swelling, accompanied by backache or other discomforts when the menstrual period comes, and the symptoms seriously affect the quality of life. Therefore, there is an urgent need A method for preparing Huayuwenjingtie cataplasm was developed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] The second aspect of the present invention provides the preparation method of the above-mentioned Huayu Wenjing plaster patch, which includes the following steps;

[0029] S1: After pulverizing and weighing the Chinese medicinal materials of the medicinal material extract formula, put them into a multifunctional extraction tank, carry out stage reflux reaction, combine the filtrate and concentrate it to a clear paste with a relative density of 1.20 at 60°C, recover the ethanol and store it for later use, and finally The extract is filtered with a strainer and sealed for later use;

[0030] S2: Weigh the ingredients according to the matrix formula, prepare gelatin, polyvinyl alcohol and sodium carboxymethyl cellulose respectively to make sols, after the colloids are dissolved, add and stir in sequence according to the above formula, and finally add stomach-soluble film coating powder and supplement Distilled water, while adding the materials into the stirring container i...

Embodiment 1

[0036] The medicinal material extract includes the following components in parts by weight: 15 parts of angelica, 15 parts of Liu Jinu, 6 parts of cinnamon, 9 parts of safflower, 9 parts of bergamot, 15 parts of Caulis Spatholobus, 12 parts of black medicine, 9 parts of galangal, 6 parts of Evodia rutaecarpa, 15 parts of curcuma, 30 parts of Daxueteng, 15 parts of Achyranthes bidentata, 12 parts of paeonol, 20 parts of fried barley, 15 parts of Toosendan, 10 parts of myrrh, and 30 parts of Smilax smilax.

[0037] Preparation of cataplasm matrix: 3.9 parts of gelatin, 3.2 parts of polyvinyl alcohol, 1.9 parts of sodium carboxymethylcellulose, 1.6 parts of castor oil, 0.96 parts of sodium polyacrylate, 1.15 parts of Tween, 0.07 parts of sorbic acid, 3.5 parts of kaolin, 6.3 parts of glycerin, 7.45 parts of tartaric acid, 1.38 parts of sorbitol, 15.6 parts of gastric-soluble film-coating powder, and 38 parts of distilled water.

[0038] The preparation method of Huayuwenjingtie c...

Embodiment 2

[0044] The medicinal material extract includes the following components by weight: 10 parts of angelica, 10 parts of Liu Jinu, 3 parts of cinnamon, 6 parts of safflower, 6 parts of bergamot, 15 parts of Caulis Spatholobus, 10 parts of black medicine, 6 parts of galangal, 3 parts of Evodia rutaecarpa, 10 parts of curcuma, 15 parts of Daxueteng, 10 parts of Achyranthes bidentata, 10 parts of paeonol, 15 parts of fried barley, 15 parts of Toosendan, 10 parts of myrrh, and 15 parts of Smilax cocos.

[0045] Preparation of cataplasm base: 5 parts of gelatin, 5 parts of polyvinyl alcohol, 2 parts of sodium carboxymethyl cellulose, 2 parts of castor oil, 1 part of sodium polyacrylate, 1.5 parts of Tween, 0.1 part of sorbic acid, 4 parts of kaolin, 8 parts of glycerin, 9 parts of tartaric acid, 2 parts of sorbitol, 18 parts of gastric-soluble film-coating powder, 40 parts of distilled water.

[0046] The preparation method of Huayuwenjingtie cataplasm comprises the following steps:

...

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PUM

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Abstract

The invention discloses a patch cataplasm for dispersing blood stasis and warming channels and a preparation method thereof. The cataplasm is composed of a medicinal material extract or chemical drugsand an appropriate matrix; the medicinal material extract comprises the following components in parts by weight: 10-15 parts of radix angelicae sinensis, 10-15 parts of artemisia anomala, 3-6 parts of cinnamon, 6-9 parts of safflower, 6-9 parts of finger citron, 15 parts of suberect spatholobus stems, 10-12 parts of combined spicebush roots, 6-9 parts of galangal, 3-6 parts of fructus evodiae, 10-15 parts of curcuma zedoary, 15-30 parts of sargentgloryvine stems, 10-15 parts of radix cyathulae, 10-12 parts of tree peony root bark, 15-20 parts of fried coix seeds, 15 parts of szechwan chinaberry fruits, 10 parts of myrrh, and 15-30 parts of poria cocos; and a water-soluble polymer material is used as a main matrix, and a medicine extract is added into the matrix to prepare the external patch cataplasm for dispersing blood stasis and warming channels. The patch cataplasm which is used for dispersing blood stasis and warming channels and is prepared by adopting a cataplasm matrix formulaand the preparation method, has no adverse effect on the stability of a main drug, has no side effect, is moderate in viscosity and elasticity, has no residue on the skin, and has no deformation of the cataplasm body; the cataplasm can be repeatedly uncovered and pasted, the drug release is long-acting, and the slow release effect is strong; and the cataplasm is suitable for preparing traditionalChinese medicine cataplasm containing different traditional Chinese medicine components.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine patches, in particular to a cataplasm for removing blood stasis and warming meridians and a preparation method thereof. Background technique [0002] As we all know, plaster refers to a class of sheet-shaped external preparations made of medicinal material extracts or chemical drugs and suitable substrates for skin sticking and can produce local or systemic effects. These include rubber plasters, poultices, and patches. [0003] Traditional plasters (soft plasters, black plasters) are all based on fat-soluble materials, which have serious defects in application: small drug load, poor transdermal performance, allergies, rashes, adhesion of fine hair, contamination of clothing, etc. [0004] In the late 1970s, Japan developed a water-soluble matrix plaster for opening up the western market. This type of plaster has been included in the "Japanese Pharmacopoeia Prescription" and is called ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/70A61K47/42A61K47/32A61K47/38A61K47/44A61K47/26A61K47/12A61K47/02A61K47/10A61P15/00
CPCA61K9/7023A61K36/185A61K36/21A61K36/232A61K36/282A61K36/286A61K36/328A61K36/486A61K36/54A61K36/58A61K36/65A61K36/71A61K36/752A61K36/754A61K36/896A61K36/8994A61K36/90A61K36/9062A61K36/9066A61K47/02A61K47/10A61K47/12A61K47/26A61K47/32A61K47/38A61K47/42A61K47/44A61K2236/333A61K2236/51A61P15/00A61K2300/00
Inventor 温洁
Owner 上海市浦东新区中医医院