Synthesis and application of imine spiro piperidine compounds

A compound, piperidine technology, applied in the field of medicine, can solve the problem that the new compound inhibits the antibacterial activity of chitin synthase and has not been reported.
CN111434664AInactive Publication Date: 2020-07-21SOUTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHWEST UNIV
Publication Date
2020-07-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses design, synthesis and application of novel imide spiro compounds. The structure of the compounds is shown as a general formula I shown in the specification, wherein R is a benzene ring or a substituted benzene ring. Bioactivity test experiments prove that most compounds show certain inhibitory activity on candida albicans, aspergillus flavus, cryptococcus neoformans and aspergillus fumigatus, and also have certain inhibitory activity on chitin synthase.
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Description

technical field

[0001] The invention belongs to the field of medicine, in particular to a kind of N-(2-(7-ethyl-1,3,6,8-tetraoxo-2,7-diazaspiro[4,4]nonane-2 Design and synthesis of -yl)ethyl)piperidine-4-carboxamides and their application in antimicrobial. Background technique

[0002] In recent years, the morbidity and mortality of invasive fungal infections have increased significantly, and fungal infections are a serious threat to human health. Some antifungal drugs currently used in clinical practice are greatly restricted in their application due to their narrow spectral activity and large nephrotoxic side effects. Poisonous antifungal drugs. Spiro compounds have rigid structures and stable structures, and have important applications in medicine, pesticides, various materials, asymmetric catalysis, etc., and have biological activities in anti-fungal, anti-inflammatory, anti-cancer, treatment of mental illness, and anti-diabetes. . In recent years, the applications o...

Claims

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