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Injectable temperature-sensitive refrigeration hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma

A technology of injection temperature and craniocerebral trauma, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., to avoid side effects, increase concentration, and improve effects

Pending Publication Date: 2020-07-31
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, shortening the time between hypothermia induction and injury remains a challenge
In addition, since TRA1 is widely distributed in various organs such as the heart, aorta, kidney, stomach, and small intestine, there are certain side effects in systemic application of T1AM.

Method used

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  • Injectable temperature-sensitive refrigeration hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma
  • Injectable temperature-sensitive refrigeration hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma
  • Injectable temperature-sensitive refrigeration hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of Injectable Temperature-Sensitive Cooling Hydrogels

[0029] Weigh 250mg of Poloxamer 407, 50mg of Poloxamer 188, and 50mg of T1AM into a 1.5ml EP tube with an analytical balance, add 950 μL of water and 50 μL of dimethyl sulfoxide (DMSO) to the EP tube, and stir well at 4 °C After 24 hours, the air bubbles were removed, and it was completely dissolved into a clear liquid to prepare a liquid hydrogel.

Embodiment 2

[0030] Example 2: Temperature-sensitive gel-forming properties and injectability of injectable temperature-sensitive cooling hydrogels

[0031] Take an appropriate amount of hydrogel in the medicine bottle, and observe the state of the hydrogel at 4°C and 37°C. For the convenience of observation, the hydrogel was injected into water at 37°C through a syringe after adding a blue chromogenic agent, and its injectability and gel-forming characteristics were observed.

Embodiment 3

[0032] Example 3: Microscopic Morphology of Injectable Temperature-Sensitive Cooling Hydrogels

[0033] Take an appropriate amount of hydrogel sample, put it in liquid nitrogen and freeze it to a solid state quickly, then put it into a freeze dryer for 48 h, take it out, grind it into a white powder, fix it on an aluminum plate, and observe it with a scanning electron microscope after spraying gold .

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PUM

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Abstract

The invention provides injectable refrigeration hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma. The hydrogel is prepared by the following steps: dissolving poloxamer 407 and poloxamer 188 in a solution containing triiodothyronine (T1AM), performing full stirring at 4 DEG C for 24 hours, removing bubbles, and performing complete dissolving into a clear liquid, thereby obtaining the liquid hydrogel. The concentrations of the components are as follows: 25% (w / v) of the poloxamer 407, 5% (w / v) of the poloxamer 188 and 5% (w / v) of the T1AM. The hydrogel preparedby the technology not only has temperature sensitivity and injectability, but also has the effect of gradually releasing T1AM in a craniocerebral trauma microenvironment to realize mild hypothermia treatment of locally damaged brain tissues.

Description

technical field [0001] The invention relates to an injectable temperature-sensitive cooling hydrogel capable of inducing local mild hypothermia to treat craniocerebral trauma, belonging to the field of craniocerebral trauma drug preparation. Background technique [0002] Traumatic brain injury (TBI) has become a serious public health problem worldwide due to its high morbidity, mortality and disability. Although the deepening understanding of the pathogenesis of craniocerebral injury, the continuous increase of new drugs and the continuous application of new technologies have significantly improved the treatment level of patients with craniocerebral trauma, but in the process of treating TBI patients, the more prominent The problem is how to combat traumatic brain injury, there are acute inflammatory reactions, edema formation and swelling, persistent blood-brain barrier (BBB) ​​and electrolyte imbalance in the internal environment, which lead to secondary damage such as per...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61K31/135A61P25/00A61P29/00
CPCA61K9/06A61K9/0019A61K47/10A61K31/135A61P25/00A61P29/00
Inventor 刘洪梅于如同韩宇涵杨晗韩正中钱峰
Owner XUZHOU MEDICAL UNIV