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Fluorescent molecular probe for identifying and detecting oxalic acid as well as preparation method and application thereof

A technology of fluorescent molecular probes and oxalic acid, applied in chemical instruments and methods, fluorescence/phosphorescence, and material analysis through optical means, can solve problems such as poor selectivity, susceptible to interference by other organic acids, and inability to achieve quantitative detection. Achieve high selectivity and sensitivity, wide application value

Inactive Publication Date: 2020-08-11
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the technical problems that the existing fluorescent probes for identifying and detecting oxalic acid by fluorescence method cannot realize quantitative detection, and have poor selectivity and are easily interfered by other organic acids, and provide a fluorescent molecular probe for identifying and detecting oxalic acid. Needle and its preparation method and application

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  • Fluorescent molecular probe for identifying and detecting oxalic acid as well as preparation method and application thereof
  • Fluorescent molecular probe for identifying and detecting oxalic acid as well as preparation method and application thereof
  • Fluorescent molecular probe for identifying and detecting oxalic acid as well as preparation method and application thereof

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Experimental program
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specific Embodiment approach 1

[0018] Specific embodiment one: the fluorescent molecular probe for identifying and detecting oxalic acid of the present embodiment, its structural formula is:

[0019] The fluorescent molecular probe can identify and detect oxalic acid content through fluorescence enhancement.

specific Embodiment approach 2

[0020] Specific embodiment two: the preparation method of the fluorescent molecular probe of identification and detection oxalic acid described in specific embodiment one, carry out according to the following steps:

[0021] 1. Add salicylic acid and concentrated sulfuric acid to methanol at a molar ratio of 1: (0.9-1.5), stir under nitrogen protection, heat to boiling and reflux for 12-18 hours; cool to room temperature, and remove methanol by rotary evaporation , washed with water several times; then extracted with dichloromethane, dried over anhydrous sodium sulfate, and separated by silica gel column chromatography to obtain intermediate I;

[0022] 2. Add intermediate I and hydrazine hydrate obtained in step 1 to ethanol at a molar ratio of 1: (2.5 to 4.5), then stir and heat to boiling and reflux for 10.5 to 13.5 hours; spin the reaction solution to dryness, and then After recrystallization from deionized water, Intermediate II was obtained;

[0023] 3. Add 8-hydroxyqui...

specific Embodiment approach 3

[0026] Embodiment 3: This embodiment differs from Embodiment 2 in that: the concentration of concentrated sulfuric acid described in step 1 is greater than or equal to 98% by mass; other aspects are the same as Embodiment 2.

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Abstract

The invention discloses a fluorescent molecular probe for identifying and detecting oxalic acid as well as a preparation method and an application thereof, which relate to a probe for identifying anddetecting oxalic acid as well as the preparation method and the application thereof. The invention aims to solve the technical problems that the existing fluorescent probe for identifying and detecting oxalic acid by using a fluorescence method cannot realize quantitative detection, is poor in selectivity and is easily interfered by other organic acids. The structural formula of the fluorescent molecular probe of the present invention is in the specification. The preparation method of the fluorescent molecular probe comprises the following steps: 1, reacting salicylic acid, concentrated sulfuric acid and methanol to prepare an intermediate I; 2, preparing an intermediate II from the intermediate I and hydrazine hydrate; 3, carrying out a reaction on 8-hydroxyquinaldine, selenium dioxide and 1, 4-dioxane to prepare an intermediate III; 4, reacting the intermediate III with the intermediate II to obtain an intermediate IV; and 5, reacting the intermediate IV with Fe<3 +> to obtain the probe. The oxalic acid is recognized and detected through fluorescence enhancement, the selectivity is high, interference of other organic acids is avoided, and the detection limit is 1.3*10<-7> mol / L.The method can be used in environment and food fields.

Description

technical field [0001] The invention relates to a probe for identifying and detecting oxalic acid, a preparation method and application thereof. Background technique [0002] Oxalic acid is a common organic dicarboxylic acid, which widely exists in plants, especially in spinach, amaranth, leek and other vegetables. Oxalic acid ingested in the body through diet can form insoluble calcium oxalate with calcium ions, which not only affects the absorption of calcium in the human body, but also increases the risk of kidney stones and other diseases. At present, the methods for detecting oxalic acid mainly include titration, colorimetry and chromatography. These traditional methods are not only complicated to operate, but also have disadvantages such as low sensitivity or high instrument price. Fluorescent molecular probes, as an emerging detection method, have attracted extensive attention due to their advantages of high sensitivity, low cost, and easy operation. Therefore, it ...

Claims

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Application Information

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IPC IPC(8): C07D215/30C09K11/06G01N21/64
CPCC07D215/30C09K11/06C09K2211/187G01N21/6428G01N21/643
Inventor 贾丽华郭祥峰高昕杨瑞赵振龙张宇
Owner QIQIHAR UNIVERSITY
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