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Nicotin-3, 5-dihydroxybenzoate compound crystal and application thereof in smokeless tobacco products

A technology of dihydroxybenzoic acid and smokeless tobacco, which is applied in the field of tobacco chemistry, can solve the problems that the release cannot provide physiological satisfaction, vigorous digestive tract discomfort, high irritation, etc., and achieves long-lasting physiological satisfaction and reduced irritation. , the effect of reducing toxicity

Pending Publication Date: 2020-08-14
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will bring about three main problems: first, excessive energy will cause discomfort in the digestive tract; second, the release is too fast and cannot provide sustained long-term physiological satisfaction; third, the taste is poor and irritating

Method used

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  • Nicotin-3, 5-dihydroxybenzoate compound crystal and application thereof in smokeless tobacco products
  • Nicotin-3, 5-dihydroxybenzoate compound crystal and application thereof in smokeless tobacco products
  • Nicotin-3, 5-dihydroxybenzoate compound crystal and application thereof in smokeless tobacco products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1. Preparation of nicotine-3,5-dihydroxybenzoate complex crystals

[0054] 1.1 Preparation of nicotine and 3,5-dihydroxybenzoic acid complex

[0055] Take 1.54g of 3,5-dihydroxybenzoic acid in an Erlenmeyer flask, add 20mL of pure water to dissolve it completely, stir until the solid is completely dissolved. For nicotine, control the reaction temperature at 40-45°C, complete the dropwise addition in 60 minutes, and sonicate until the reaction ends. The solution obtained from the reaction was subjected to light-shielding treatment, and then freeze-dried to obtain a powdery solid.

[0056] 1.2 Complex single crystal culture

[0057] Take an appropriate amount of the solid obtained in step 1.1, add methanol dropwise until it is saturated, filter, place the filtrate in a dark place at room temperature, and let it stand until the crystal grows to obtain a light yellow transparent blocky solid.

[0058] 2. Structural characterization of nicotine-3,5-dihydroxybenzoate compl...

Embodiment 2

[0083] A gum-based chewing tobacco containing the above-mentioned nicotine-3,5-dihydroxybenzoate complex crystal, the gum-based chewing tobacco includes a gum base, a sweetener, an acid-base regulator, an essence, an edible Colours, humectants and nicotine-3,5-dihydroxybenzoate complex crystals;

[0084] Wherein, the weight portion of gum base is 10 parts;

[0085] The weight portion of sweetener is 20 parts;

[0086] The weight portion of acid-base regulator is 1 part;

[0087] The weight portion of food coloring is 0.5 part;

[0088] The weight part of essence is 1 part;

[0089] The weight part of humectant is 1 part;

[0090] The mass of the nicotine-3,5-dihydroxybenzoate complex crystal is 1% of the total mass of the gum base, sweetener, acid-base regulator, essence, food coloring and moisturizer.

[0091] The acid-base regulator is sodium bicarbonate; the humectant is propylene glycol.

Embodiment 3

[0093] A gum-based chewing tobacco containing the above-mentioned nicotine-3,5-dihydroxybenzoate complex crystal, the gum-based chewing tobacco includes a gum base, a sweetener, an acid-base regulator, an essence, an edible Colours, humectants and nicotine-3,5-dihydroxybenzoate complex crystals;

[0094] Wherein, the weight portion of gum base is 30 parts;

[0095] The weight portion of sweetener is 70 parts;

[0096] The weight portion of acid-base regulator is 5 parts;

[0097] The weight portion of food coloring is 5 parts;

[0098] The weight portion of essence is 5 parts;

[0099] The weight portion of humectant is 5 parts;

[0100] The mass of the nicotine-3,5-dihydroxybenzoate complex crystal is 10% of the total mass of the gum base, sweetener, acid-base regulator, essence, food coloring and moisturizer.

[0101] The acid-base regulator is sodium carbonate; the humectant is glycerol.

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Abstract

The invention relates to a nicotin-3, 5-dihydroxybenzoate compound crystal and application thereof in smokeless tobacco products, and belongs to the technical field of tobacco chemistry. The molecularformula of the crystal is C17H24N2O6. The crystal belongs to a monoclinic system, the space group is P21, and the cell parameters are as follows: a=8.4365 (6) angstroms, b=13.1486 (11) angstroms, c=8.6019 (5) angstroms, [alpha]=90.00 degrees, [beta]=101.976 (6) degrees, [gamma]=90.00 degrees and V=933.42 (12) angstroms. The invention provides a preparation method of nicotin-3, 5-dione. Accordingto the present invention, the 1, 5-dihydroxybenzoate compound crystal is adopted to replace the nicotine monomer to be used in smokeless tobacco products, such that the irritation of the protonated nicotine on the oral cavity and the respiratory tract is significantly reduced compared to the free nicotine, the high nicotine concentration is achieved in the limited aerosol, and the toxicity of thenicotine on the human body is substantially reduced.

Description

technical field [0001] The invention belongs to the technical field of tobacco chemistry, and in particular relates to a nicotine-3,5-dihydroxybenzoate complex crystal and its application in smokeless tobacco products. Background technique [0002] With the change of people's lifestyle and consumption concept and the rapid progress of science and technology, the needs and concerns of tobacco consumers are constantly changing. Restricted by many places, the development of new tobacco products has become inevitable. [0003] Smokeless tobacco products in new tobacco products refer to tobacco products that are not burned and consumed through the mouth or nasal cavity; in terms of use behavior, they refer to tobacco products that are not used by smoking, including: oral tobacco (chewing tobacco) cigarettes, snus in pouches), dry snuff, moist snuff, paste tobacco, etc. [0004] Smokeless tobacco products provide nicotine to the human body through mouth, sucking, chewing, etc. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/16A24B13/00
CPCA24B13/00A24B15/16
Inventor 杨继唐石云刘志华朱瑞芝刘春波向能军司晓喜何沛张凤梅蒋薇王昆淼李振杰苏钟璧
Owner CHINA TOBACCO YUNNAN IND
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