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Myocardial patch with negative poisson ratio structure in conductive stability and preparation method thereof

A technology with negative Poisson's ratio and stability, applied in the field of biomedical materials, can solve problems such as difficulty in maintaining electrical conductivity and difficulty in matching electrical and mechanical behaviors of myocardial patches

Active Publication Date: 2020-08-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a negative Poisson's ratio myocardial patch with conductive stability and a preparation method thereof. Problems with the electrical and mechanical behavior of cardiac tissue

Method used

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  • Myocardial patch with negative poisson ratio structure in conductive stability and preparation method thereof
  • Myocardial patch with negative poisson ratio structure in conductive stability and preparation method thereof
  • Myocardial patch with negative poisson ratio structure in conductive stability and preparation method thereof

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Embodiment 1

[0115] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0116] (1) adding a certain mass fraction of pyrrole monomer into ferric chloride solution and stirring for 4h, then filtering, washing and drying to obtain polypyrrole particles (the molar ratio of ferric chloride to pyrrole monomer is 2.3:1);

[0117] (2) adding polypyrrole particles to 30wt% polyurethane solution and stirring evenly to obtain a solution (30wt% of polypyrrole particles in the solution);

[0118] (3) immerse the polyurethane yarn and the polylactic acid yarn in the above solution for 5 minutes, fully absorb;

[0119] (4) After washing polypyrrole-coated polyurethane yarn and polypyrrole-coated polylactic acid yarn with deionized water for 2 times, dry at room temperature to obtain conductive polypyrrole-coated polyurethane yarn and polypyrrole-coated polylactic acid yarn;

[0120] (5) Using conductive polypyrrole-c...

Embodiment 2

[0125] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0126] (1) Polycaprolactone yarn is selected as elastic yarn, polylactic acid yarn is used as non-elastic yarn, double-needle plate latch weft knitting machine is adopted, and the number of non-elastic yarn and elastic yarn is 2:1 alternately arrangement;

[0127] (2) Knitting needles according to Figure 4 The weaving pattern shown is regularly looped to form a concave hexagonal pattern;

[0128] (3) Before the fabric is off the machine, coat the fabric 3 times with a polyurethane solution containing sodium dodecylbenzenesulfonate and ammonium persulfate; wherein, in the polyurethane solution, the content of sodium dodecylbenzenesulfonate is 1 % w / v, the content of ammonium persulfate is 3% w / v, the content of polyurethane is 10% w / v;

[0129] (4) Fumigate the coated fabric with pyrrole monomer (excess) at 4°C for 12h;

[0130] ...

Embodiment 3

[0134] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0135] (1) Select polycaprolactone yarn as elastic yarn raw material, polylactic acid as non-elastic yarn, and adopt a rapier loom with multiple weft yarn supply and dobby shedding mechanism;

[0136] (2) Winding, warping, sizing, and reeding warp yarns (polycaprolactone yarns and polylactic acid yarns alternately prepared at a ratio of 1:1), and weft yarns are made of polycaprolactone yarns. figure 2 (a) shows the schematic diagram, image 3 As shown in the tissue diagram, opening, weft insertion, beating up, and coiling are performed to obtain the base material of the myocardial patch; wherein, tissue 1 ( image 3 In (a)) is plain weave, weave 2 ( image 3 (b)) is twill weave, and weave 3 ( image 3 (c)) is a structure in which the warp yarns alternately float on the weft yarns, and the structure density of structures 1, 2 and ...

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Abstract

The invention relates to a myocardial patch with a negative poisson ratio structure in conductive stability and a preparation method thereof. The method comprises the following steps of weaving or knitting a myocardial patch base material with an inner concave polygon as a minimum structural unit, and coating the surface of the base material with a conductive coating to prepare the myocardial patch with the negative poisson ratio structure in conductive stability; or treating the yarns to prepare conductive coating yarns, and weaving or knitting the myocardial patch with the negative poisson'sratio structure, which takes the conductive coating yarns as a raw material and takes the concave polygon as the minimum structural unit, by adopting a weaving or knitting manner, so as to obtain themyocardial patch. The resistance change rate of the prepared myocardial patch is lower than 5% under 50% tensile deformation, the tensile rate of the minimum structural unit is within 50%, the fabricis of a negative poisson's ratio structure and expands in the vertical direction of a tensile load, and the fabric shows the anisotropy of the negative poisson's ratio effect and the Young modulus; and the myocardial patch is matched with normal myocardial tissue mechanical behaviors.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a conductive stability negative Poisson's ratio structure myocardial patch and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the major diseases that cause human death in the world, accounting for more than 40% of the death from disease, among which myocardial infarction and other types of ischemic heart disease are the leading causes of death. The number of people who die of myocardial infarction and its complications in my country has exceeded 1 million every year, and the incidence rate is increasing year by year. Although existing interventional therapy and thrombolytic reinfusion therapy have significantly reduced mortality in the acute phase of myocardial infarction. However, the myocardial tissue at the lesion site is necrotic and cannot be regenerated, and will be replaced by surrounding connective tissue to form s...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/50C09D5/24C09D175/04A61F2/00
CPCA61L27/50A61L27/3834C09D175/04C09D5/24A61F2/0063C08L79/04C08G61/124H01B1/127D10B2509/06D10B2401/16D04B1/18C08G2261/11C08G2261/3221C08G2261/43C08G2261/93D03D13/004D03D15/283D03D15/533D03D15/56D10B2331/041D10B2331/10D10B2401/06A61F2/2481D02G3/448D02G3/441D02G3/404D10B2403/0331C08F2/04C08F126/06C09D139/04D03D17/00D04B1/10D10B2401/061D10B2403/03
Inventor 毛吉富李沂蒙高娅娅李超婧王富军王璐
Owner DONGHUA UNIV
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