A conductive stable negative Poisson's ratio structure myocardial patch and its preparation method

A technology with negative Poisson's ratio and stability, which is applied in the field of biomedical materials, can solve the problems of myocardial patches that are difficult to match electrical and mechanical behaviors, and difficult to maintain electrical conductivity, so as to achieve excellent mechanical properties, stable electrical conductivity, and meet the requirements of stretching. force effect

Active Publication Date: 2021-05-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a negative Poisson's ratio myocardial patch with conductive stability and a preparation method thereof. Problems with the electrical and mechanical behavior of cardiac tissue

Method used

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  • A conductive stable negative Poisson's ratio structure myocardial patch and its preparation method
  • A conductive stable negative Poisson's ratio structure myocardial patch and its preparation method
  • A conductive stable negative Poisson's ratio structure myocardial patch and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0116] (1) adding a certain mass fraction of pyrrole monomer into ferric chloride solution and stirring for 4h, then filtering, washing and drying to obtain polypyrrole particles (the molar ratio of ferric chloride to pyrrole monomer is 2.3:1);

[0117] (2) adding polypyrrole particles to 30wt% polyurethane solution and stirring evenly to obtain a solution (30wt% of polypyrrole particles in the solution);

[0118] (3) immerse the polyurethane yarn and the polylactic acid yarn in the above solution for 5 minutes, fully absorb;

[0119] (4) After washing polypyrrole-coated polyurethane yarn and polypyrrole-coated polylactic acid yarn with deionized water for 2 times, dry at room temperature to obtain conductive polypyrrole-coated polyurethane yarn and polypyrrole-coated polylactic acid yarn;

[0120] (5) Using conductive polypyrrole-c...

Embodiment 2

[0125] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0126] (1) Polycaprolactone yarn is selected as elastic yarn, polylactic acid yarn is used as non-elastic yarn, double-needle plate latch weft knitting machine is adopted, and the number of non-elastic yarn and elastic yarn is 2:1 alternately arrangement;

[0127] (2) Knitting needles according to Figure 4 The weaving pattern shown is regularly looped to form a concave hexagonal pattern;

[0128] (3) Before the fabric is off the machine, coat the fabric 3 times with a polyurethane solution containing sodium dodecylbenzenesulfonate and ammonium persulfate; wherein, in the polyurethane solution, the content of sodium dodecylbenzenesulfonate is 1 % w / v, the content of ammonium persulfate is 3% w / v, the content of polyurethane is 10% w / v;

[0129] (4) Fumigate the coated fabric with pyrrole monomer (excess) at 4°C for 12 hours;

[0...

Embodiment 3

[0134] A preparation method of a negative Poisson's ratio structure myocardial patch with conductive stability, comprising the following steps:

[0135] (1) Select polycaprolactone yarn as elastic yarn raw material, polylactic acid as non-elastic yarn, and adopt a rapier loom with multiple weft yarn supply and dobby shedding mechanism;

[0136] (2) Winding, warping, sizing, and reeding warp yarns (polycaprolactone yarns and polylactic acid yarns alternately prepared at a ratio of 1:1), and weft yarns are made of polycaprolactone yarns. figure 2 (a) shows the schematic diagram, image 3 As shown in the tissue diagram, opening, weft insertion, beating up, and coiling are performed to obtain the base material of the myocardial patch; wherein, tissue 1 ( image 3 In (a)) is plain weave, weave 2 ( image 3 (b)) is twill weave, and weave 3 ( image 3 (c)) is a structure in which the warp yarns alternately float on the weft yarns, and the structure density of structures 1, 2 and ...

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Abstract

The present invention relates to a negative Poisson's ratio myocardial patch with conductive stability and a preparation method thereof. The surface is coated with a conductive coating to obtain a negative Poisson's ratio structure myocardial patch with conductive stability; or, the yarn is first processed to make a conductive coated yarn, and then the conductive coated yarn is used as a raw material for weaving or Knitting and weaving a negative Poisson's ratio structure myocardial patch with concave polygon as the minimum structural unit; the resistance change rate of the prepared myocardial patch is less than 5% under 50% tensile deformation, and the minimum structure The stretch rate of the unit is within 50%, the fabric exhibits a negative Poisson's ratio structure, and expands in the vertical direction of the tensile load, the fabric exhibits a negative Poisson's ratio effect and anisotropy of Young's modulus, which is similar to that of normal myocardial tissue Mechanical behavior matches.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a conductive stable negative Poisson's ratio structure myocardial patch and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the major diseases leading to human death in the world, accounting for more than 40% of disease deaths, among which myocardial infarction and other types of ischemic heart disease are the leading causes of death. The number of people dying of myocardial infarction and its complications in my country has exceeded 1 million every year, and the incidence rate is increasing year by year. Although the existing interventional therapy and thrombolytic reperfusion therapy have significantly reduced the mortality rate in the acute phase of myocardial infarction. However, the myocardial tissue in the lesion is necrotic and unable to regenerate, and will be replaced by surrounding connective tissue to form scar t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/38A61L27/50C09D5/24C09D175/04A61F2/00
CPCA61L27/50A61L27/3834C09D175/04C09D5/24A61F2/0063C08L79/04C08G61/124H01B1/127D10B2509/06D10B2401/16D04B1/18C08G2261/11C08G2261/3221C08G2261/43C08G2261/93D03D13/004D03D15/283D03D15/533D03D15/56D10B2331/041D10B2331/10D10B2401/06A61F2/2481D02G3/448D02G3/441D02G3/404D10B2403/0331C08F2/04C08F126/06C09D139/04D03D17/00D04B1/10D10B2401/061D10B2403/03
Inventor 毛吉富李沂蒙高娅娅李超婧王富军王璐
Owner DONGHUA UNIV
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