Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Photosensitizer-loaded painless soluble microneedle, microneedle array and preparation method

A microneedle array and photosensitizer technology, applied in microneedle, phototherapy, laser welding equipment, etc., can solve problems such as unreasonable drug delivery methods, achieve the effects of improving transdermal efficiency, shortening treatment time, and avoiding toxic and side effects

Inactive Publication Date: 2020-08-18
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a painless soluble microneedle loaded with a photosensitizer and a microneedle array and a preparation method to solve the technical problems of unreasonable administration methods in photodynamic therapy and patients needing pain relief measures in photodynamic therapy. At the same time, it solves the problem of preparation of painless dissolvable microneedle array loaded with photosensitizer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photosensitizer-loaded painless soluble microneedle, microneedle array and preparation method
  • Photosensitizer-loaded painless soluble microneedle, microneedle array and preparation method
  • Photosensitizer-loaded painless soluble microneedle, microneedle array and preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] A preparation method of a painless soluble microneedle array carrying photosensitizer, comprising the following steps:

[0041] 1) Preparation of polydimethylsiloxane (PDMS) mold plate: place polydimethylsiloxane (polydimethylsiloxane (PDMS)) and curing agent in a beaker, stir well, and then set Remove the air bubbles in an ultrasonic cleaning machine, then pour the above mixture into a disposable petri dish and spread it flat; put the petri dish into a constant temperature vacuum drying oven, evacuate to remove all air bubbles in the mixture, and heat it to make the mixture Polysiloxane (PDMS) is solidified; after cooling, the solidified polydimethylsiloxane (PDMS) is peeled from the petri dish to obtain a polydimethylsiloxane (PDMS) mold plate;

[0042] 2) Laser etching polydimethylsiloxane (PDMS) microneedle female mold: Use an integrated fiber carbon dioxide laser marking machine to set parameters to etch the polydimethylsiloxane (PDMS) mold plate to remove excess materi...

Embodiment 1

[0059] Example 1: Preparation of soluble hyaluronic acid microneedles loaded with 5-ALA and lidocaine

[0060] 1. Preparation of polydimethylsiloxane (PDMS) mold plate: Place polydimethylsiloxane (polydimethylsiloxane (PDMS)) and curing agent in a beaker at a mass ratio of 10:1 , Stir for about 5 minutes, then place in an ultrasonic cleaning machine for about 10 minutes to remove air bubbles, and then pour the above mixture into a disposable petri dish to make the thickness about 3-4 mm. Put the petri dish into a constant-temperature vacuum drying box, and evacuate to a vacuum of -0.08 MPa to remove all bubbles in the mixture. Heat at 80°C for 2h to solidify the polydimethylsiloxane (PDMS); after cooling, peel off the cured polydimethylsiloxane (PDMS) to obtain a polydimethylsiloxane (PDMS) mold plate .

[0061] 2. Laser etching polydimethylsiloxane (PDMS) microneedle female mold: use an integrated fiber CO2 laser marking machine to set the parameters to etch the polydimethylsilo...

Embodiment 2

[0064] Example 2-6: Painless soluble photodynamic therapy microneedles with different parameters

[0065] In addition, according to the method of Example 1, by adjusting the structure of the polydimethylsiloxane (PDMS) microneedle female mold and the concentration of the photosensitizer solution, microneedles with various parameters as shown in Table 1 were obtained.

[0066] The painless soluble photodynamic therapy microneedles with different lengths, base diameters, distance between adjacent needle tips, photosensitizer types, and photosensitizer content prepared by the method of Example 1 of the present invention, the results are as follows:

[0067]

[0068] The compression time during treatment is 1s to 10min, and the time interval from the start of compression to the irradiation of excitation light is 10min to 24h.

[0069] Application of soluble microneedle with photosensitizer in tumor detection

[0070] 1. Prepare 5-ALA-loaded soluble hyaluronic acid microneedles (including 10...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Lengthaaaaaaaaaa
Bottom diameteraaaaaaaaaa
Concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a photosensitizer-loaded painless soluble microneedle. The microneedle comprises a base, a soluble polymer needle body positioned on the base and a needle tip loaded with a photosensitizer and an anesthetic, the base, the needle body and the needle tip are integrally formed. The invention further discloses a painless soluble microneedle array carrying the photosensitizer, the microneedle array consists of more than one microneedle. The invention further discloses a preparation method of the photosensitizer-loaded painless soluble microneedle array. The preparation method comprises the following steps: 1) preparing a polydimethylsiloxane (PDMS) mold plate; 2) carrying out laser etching on a polydimethylsiloxane (PDMS) micro-needle female die; according to the preparation method of the painless soluble microneedle array loaded with the photosensitizer, the technical problems that in photodynamic therapy, the administration mode is unreasonable, and a patient needsto take analgesic measures in photodynamic therapy can be solved, Meanwhile, the preparation problem of the painless soluble microneedle array loaded with the photosensitizer is solved.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and more specifically, relates to a painless soluble microneedle and microneedle array carrying a photosensitizer and a preparation method thereof. Background technique [0002] Photodynamic therapy is a series of photochemical reactions between endogenous or exogenous photosensitizers in target cells and oxygen under the action of light waves of specific wavelengths to generate singlet oxygen, oxygen ions, peroxides, and free oxygen. A treatment method that induces cell death and selectively destroys target tissues. However, on the one hand, the photodynamic therapy process will cause more severe pain. 44% of patients need photodynamic therapy. Use pain relief measures. On the other hand, the current administration of photosensitizers in photodynamic therapy is mostly topical (such as 5-ALA) or intravenous injection (such as Hemporfin). External use of photosensitizers is often applied in the fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61M37/00A61N5/06B29D7/00B23K26/362B23K26/402
CPCA61M37/0015A61M2037/0023A61M2037/0053A61N5/062B23K26/362B23K26/402B29D7/00A61K9/0021A61K31/122A61K31/167A61K31/197A61K31/245A61K31/404A61K31/445A61K41/0061A61K45/06A61M2037/0046A61K2300/00
Inventor 陶娟朱今巾朱锦涛李钰策张连斌杜虹瑶
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com