Degradable core-shell type oxidized calcium alginate gel microsphere, and preparation method and application thereof

A technology for oxidizing sodium alginate and calcium alginate, applied in the field of materials, can solve the problems of poor monodispersity of shell-core structure microspheres, and achieve the effects of controllable release, uniform size and structure, and high monodispersity.

Active Publication Date: 2020-08-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention provides a degradable core-shell oxidized calcium alginate gel microsphere and a preparation method thereof, which are used to solve the problem of poor monodispersity of core-shell structure microspheres prepared by existing preparation methods

Method used

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  • Degradable core-shell type oxidized calcium alginate gel microsphere, and preparation method and application thereof
  • Degradable core-shell type oxidized calcium alginate gel microsphere, and preparation method and application thereof
  • Degradable core-shell type oxidized calcium alginate gel microsphere, and preparation method and application thereof

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preparation example Construction

[0056] This embodiment provides a method for preparing degradable core-shell oxidized calcium alginate gel microspheres based on microfluidics, including the following steps:

[0057] First, fabricate the microfluidic device, see figure 1 , is a schematic structural diagram of the microfluidic device used in the embodiment of the present invention. A circular capillary glass tube is drawn into two sections of tapered capillary glass tubes with a specific inner diameter of the tip using a capillary glass tube drawing instrument, and one of the capillary glass tubes is named the first tapered capillary tube 1, and the other The tip of the first capillary glass tube is ground into a larger opening with sandpaper, named as the second tapered capillary tube 2;

[0058] Use trimethyl[3-(2-methoxy)propyl]silane liquid to do hydrophilic treatment on the surface of the first tapered capillary 1, and dry it with nitrogen; Do hydrophobic treatment on the surface of the shaped capillary...

Embodiment 1

[0067] In this embodiment, the fabrication of a microfluidic device includes the following steps:

[0068] Step 1) Draw a circular capillary glass tube (inner diameter 580 μm, outer diameter 1.0 mm) into two tapered capillary glass tubes with a tip inner diameter of about 40 μm using a capillary glass tube drawing apparatus;

[0069] Step 2) Sand the tip of one of the capillary glass tubes into a larger opening (with an inner diameter of about 380 μm), and name it the second tapered capillary 2; the other one is not polished, and is named the first tapered capillary 1;

[0070] Step 3) Treat the first conical capillary 1 with a trimethyl[3-(2-methoxy)propyl]silane liquid (purity greater than 99%) for 5 minutes, take it out and dry it with nitrogen;

[0071] Step 4) Soak the second conical capillary 2 with a toluene solution of 0.1% (v / v) octadecyltrichlorosilane for 20 minutes, take it out and dry it with nitrogen;

[0072] Step 5) Insert the tip of the first tapered capilla...

Embodiment 2

[0076] The present embodiment carries out the preparation of oxidized sodium alginate, comprises the following steps:

[0077] Step 1) disperse 4.0 g of sodium alginate in 20 mL of ethanol solution to obtain sodium alginate ethanol solution;

[0078] Step 2) dissolving 1.07g of sodium periodate in 20mL pure water to obtain sodium periodate solution;

[0079] Step 3) mixing sodium alginate ethanol solution and sodium periodate solution to obtain a mixed solution, and performing a magnetic stirring reaction on the mixed solution for 6 hours at room temperature in the dark;

[0080] Step 4) transfer the reacted solution to a dialysis bag (MWCO 12,000), and dialyze in pure water for 2 days;

[0081] Step 5) After the dialysis is completed, the solution in the dialysis bag is collected, and purified oxidized sodium alginate is obtained by freeze-drying. The degree of oxidation of the oxidized sodium alginate obtained in this example is about 25%.

[0082] see Figure 4 , is the...

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Abstract

The invention belongs to the technical field of materials, and particularly relates to a degradable core-shell type oxidized calcium alginate gel microsphere, and a preparation method and applicationthereof. According to the preparation method disclosed by the invention, the degradable core-shell type oxidized calcium alginate gel microsphere is prepared on the basis of micro-fluidic control; andan inner oil-phase fluid, a water-phase fluid and an outer oil-phase fluid form oil/water/oil double emulsion droplets, an acidic oil phase fluid containing organic acid is introduced into the downstream position of the oil/water/oil double emulsion droplets, calcium hydrochloride nanoparticles in a water phase of the oil/water/oil double emulsion droplets are rapidly dissolved, and free calciumions are released, so oxidized alginate in a water phase and the calcium ions are initiated to undergo rapid cross-linking so as to form a gelatinous oxidized alginate layer, and the degradable core-shell type oxidized calcium alginate gel microsphere is obtained. The degradable core-shell type oxidized calcium alginate gel microsphere prepared by the preparation method has the advantages that a size structure is uniform and monodispersity is high.

Description

technical field [0001] The invention belongs to the field of material technology, and in particular relates to a degradable core-shell type oxidized calcium alginate gel microsphere and a preparation method and application thereof. Background technique [0002] Core-shell structure microspheres generally refer to composite spherical particles whose particle size is in the range of microns and whose shell and core structures are composed of different materials. The core-shell structure microspheres are small in size and have multifunctional layers, and have been widely used in drug carriers, food chemical industry, medical diagnosis and other fields in recent years. By designing the composition, structure, size and other parameters of the core-shell structure microspheres, the optimization and regulation of their functions can be realized. For example, by changing the degree of polymerization, thickness, and porosity of the shell of the core-shell drug-loaded microspheres, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
CPCB01J13/14
Inventor 黄璐
Owner SUN YAT SEN UNIV
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