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Hemostatic sponge as well as preparation method and application thereof

A technology of composite sponge and hemostatic material, applied in the field of hemostatic sponge and its preparation, can solve the problems of non-biodegradation, toxic degradation products, hindering biosafety and clinical trial approval, etc., and achieves ingenious preparation method, death prevention, design clever effect

Active Publication Date: 2020-09-04
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, material degradation is a significant problem
Some materials are either non-biodegradable or have toxic degradation products, hindering biosafety and clinical trial approval

Method used

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  • Hemostatic sponge as well as preparation method and application thereof
  • Hemostatic sponge as well as preparation method and application thereof
  • Hemostatic sponge as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: the preparation of sodium alginate / chitosan / fucoidan sulfate composite sponge

[0051] method:

[0052] (1) Sodium alginate is dissolved in deionized water to prepare an aqueous sodium alginate solution with a mass percent concentration of 10%; chitosan is dissolved in an aqueous acetic acid solution with a volume percent concentration of 1% to prepare a mass percent concentration of 10%. chitosan solution.

[0053] (2) Under the condition of mixer 500r / min, according to chitosan: sodium alginate is the weight ratio of 1:3, mix sodium alginate aqueous solution and chitosan solution, keep stirring for 2h, take it out, and pour it into a fixed mold , sealed and allowed to stand overnight to obtain a gel.

[0054] (3) The gel was taken out, frozen in liquid nitrogen, and then transferred into a freeze dryer to freeze-dry to obtain a cross-linked body.

[0055] (4) Preparation of fucoidan sulfate solution: dissolving fucoidan sulfate in deionized water to p...

Embodiment 2

[0059] Example 2: General Characterization of the Composite Sponge of Example 1

[0060] method:

[0061] The sodium alginate / chitosan / fucoidan composite sponge prepared in Example 1 is compared with the sodium alginate / chitosan composite sponge without adding fucoidan sulfate, and the conventional swelling rate and water retention of the sponge are carried out test.

[0062] The test method of swelling rate: Soak the sponge in PBS, take it out after 2 minutes, absorb excess water, weigh it, compare it with the sponge before absorbing water, and calculate the swelling rate.

[0063] Calculation of water retention rate: After the sponge is saturated and absorbs water, put it in a centrifuge and centrifuge at a speed of 5000r / min for 3 minutes, then weigh the sponge after centrifugation, and compare the weight with the sponge before the initial water absorption to calculate the water retention Rate.

[0064] result:

[0065] The swelling rate and water retention rate of sodi...

Embodiment 3

[0066] Embodiment 3: the preparation of sodium alginate / chitosan / fucoidan sulfate composite sponge

[0067] method:

[0068] (1) Sodium alginate is dissolved in deionized water to prepare a 10% sodium alginate aqueous solution by mass percent concentration; chitosan is dissolved in 1% acetic acid by volume concentration to prepare 10% by mass percent concentration Chitosan solution;

[0069] (2) Under the condition of mixer 500r / min, according to chitosan: sodium alginate is the weight ratio of 1:3, mix sodium alginate aqueous solution and chitosan solution, keep stirring for 2h, take it out, and pour it into a fixed mold , sealed and allowed to stand overnight to obtain a gel.

[0070] (3) Take out the gel, freeze it in a refrigerator at -20°C overnight for freezing, and then transfer it to a freeze dryer to freeze-dry to obtain a cross-linked body.

[0071] (4) Preparation of fucoidan sulfate solution: dissolve fucoidan sulfate in deionized water to prepare an aqueous sol...

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Abstract

The invention discloses a hemostatic sponge as well as a preparation method and application thereof. The hemostatic composite sponge is prepared from raw materials including chitosan, sodium alginateand fucoidan in a weight ratio being 1:(1-6):(1-6). The sponge has better swelling and water absorption characteristics, can quickly absorb blood at a wound and cause concentration of blood cells so as to induce hemostasis cascade reaction, and the sponge can be locally converted into a gel state to glue and close the wound after absorbing blood, and plays a better hemostatic role in an aorta hemorrhea model to complete hemostasis quickly. The product can effectively prevent death caused by hemorrhea and win precious rescue time for further hospital sending and treatment.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a hemostatic sponge and its preparation method and application. Background technique [0002] Hemorrhage is the leading cause of death on the battlefield. Especially in modern warfare, the direct intervention of ground combatants is mainly in the later stage of urban warfare (that is, street warfare) and special operations. In these two cases, the battlefield is generally far away from the rear base, and the combatants are relatively scattered, which is not conducive to emergency treatment on the battlefield. . Therefore, the development of effective battlefield emergency hemostatic materials suitable for individual soldiers is of great significance for battlefield rescue in the context of modern warfare. [0003] At present, as the military of various countries attaches great importance to body armor, internal cavity bleeding has decreased, and extremity bleeding is still t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/0036A61L24/043A61L2400/04C08L5/08C08L5/04C08L5/00
Inventor 喻青松甘志华牛昆
Owner BEIJING UNIV OF CHEM TECH
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