Method for preparing hinokitiol metal compound and complex

Abstract

The invention provides a method for preparing a hinokitiol metal compound or a hinokitiol ammonium compound. The method comprises the following steps: dissolving hinokitiol in a water-soluble organicsolvent to obtain a hinokitiol solution with a hinokitiol concentration of 6-25 mol / L; fully mixing and reacting the obtained hinokitiol solution with an aqueous solution of water-soluble metal salt or ammonium salt at room temperature, wherein the water-soluble metal salt is selected from metal salt with solubility not lower than 35 g / 100ml at room temperature, or the concentration of the aqueoussolution of the water-soluble metal salt or ammonium salt is not lower than 25% at room temperature, and the aqueous solution of the water-soluble metal salt or ammonium salt is further preferably asaturated solution of the water-soluble metal salt at 30-50 DEG C; and controlling the molar ratio of the water-soluble metal salt or ammonium salt to the hinokitiol to be 1: (0.9-5) to prepare a hinokitiol metal compound or hinokitiol ammonium compound solution. The method provided by the invention can fundamentally improve the instability characteristic that the hinokitiol is easy to decompose when meeting light, and avoids environmental pollution load and treatment cost of wastewater caused by the use of an acid solution.

Description

technical field [0001] The invention relates to a method for preparing an organic compound, in particular to a method for preparing a cypress alcohol metal compound and a compound. Background technique [0002] Hinokitiol, also known as hinokitiol, hinokitiol or hinokitiol, has good broad-spectrum antibacterial properties, moisture retention and pest repelling effects. It is a high-safety raw material for the preparation of antibacterial agents and insect repellents. Surrounding that cypress alcohol has broad-spectrum antibacterial and antifungal properties, inhibits ALDH activity and self-renewal ability in glioma stem cells, inhibits carcinogenicity in vitro, inhibits tyrosinase, inhibits plant production of ethylene, and has the properties of imparting cell activity, etc. People apply it in the development of many products such as medicine development, hygiene products, cosmetics, hair care, food preservation, etc. [0003] Cinnamon alcohol has a minimum inhibitory conce...

AI Technical Summary

Problems solved by technology

Among them, the Japanese published patent JP flat 1-53855 (manufacturing method of water-soluble cypress alcohol) drops the cypress alcohol solution dissolved in the lower alcohol into the powdered salt compound constantly stirred and mixed to prepare the cypress alcohol metal Compound, although improved to a certain extent the unstable characteristics of cypress alcohol that is easy to decompose when exposed to light, it does not sufficiently suspend and evenly disperse the cypress alcohol organic solvent solution, causing the cypress alcohol solution to be added dropwise to powdery salts When compounding, the material quantity contrast difference is huge, thus, the homogeneous property difference of product is greatly affected by stirring and mixing and the grinding of powdery salt compounds, etc., and can not make cypress alcohol and metal ion fully compounded evenly, and its exposure to light The characteristics of easy decomposition have not been fundamentally improved

In CN101396021A, acid solution is used in the preparation process of cypress alcohol metal compound, which causes costs such as waste water treatment and environmental load, which is not conducive to industrialization promotion