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Preparation method of biodegradable intravascular stent material

A vascular stent and biological technology, applied in the field of medical materials, can solve the problems of wide relative molecular weight distribution, difficult to control degradation rate, low thermal deformation temperature, etc., and achieve the effect of convenient operation, weakened self-degradation, and simple operation process

Inactive Publication Date: 2020-09-04
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when polylactic acid is used in medical treatment, it encounters the following problems: (1) polylactic acid has a large number of ester bonds, and its hydrophilicity is weak. When it is used as a tissue engineering material and a carrier material for hydrophilic drugs such as proteins and polypeptides, It has seriously affected its compatibility with cells and drugs; (2) The degradation of polylactic acid comes from the hydrolysis of the ester bond on the polymer chain, and the breakage of the ester bond produces a large amount of carboxylic acid, and the accumulation of carboxylic acid makes the organism Local acidity is too large and inflammation occurs, local severe water accumulation and other problems, and a large amount of carboxylic acid will produce self-catalytic degradation effect, making the degradation rate difficult to control; (3) polylactic acid is a linear copolymer, and its relative molecular weight distribution is too high. Wide, low heat distortion temperature, poor impact resistance, high brittleness, difficult to achieve the required strength

Method used

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  • Preparation method of biodegradable intravascular stent material
  • Preparation method of biodegradable intravascular stent material
  • Preparation method of biodegradable intravascular stent material

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A preparation method of a biodegradable vascular stent material, comprising:

[0034] (1) Preparation of polygluconic acid-glycolic acid: adding gluconic acid and glycolic acid to the solvent, adding a dehydrating agent, adding a catalyst, and stirring and refluxing for 12 hours at a temperature of 140°C to obtain polygluconic acid-glycolic acid; The above-mentioned solvent is dimethyl sulfoxide, the above-mentioned dehydrating agent is N,N-dicyclohexylcarbodiimide, and the above-mentioned catalyst is 4-dimethylaminopyridine;

[0035] (2) Preparation of polylactic acid: Weigh lactic acid and add it to a flask, raise the temperature to 120°C, remove water for 60min at a pressure of 60kPa, add catalyst under nitrogen protection, raise the temperature to 170°C at 3kPa, and react for 8h. After the reaction is over, add acetone to dissolve the product, then pour it into a large amount of deionized water to precipitate polylactic acid, wash it three times, and dry it in vacuu...

Embodiment 2

[0038] A preparation method of a biodegradable vascular stent material, comprising:

[0039] (1) Preparation of polygluconic acid-glycolic acid: adding gluconic acid and glycolic acid to the solvent, adding a dehydrating agent, adding a catalyst, and stirring and refluxing for 12 hours at a temperature of 140°C to obtain polygluconic acid-glycolic acid; The solvent is dimethyl sulfoxide, the dehydrating agent is N,N-dicyclohexylcarbodiimide, and the catalyst is 4-dimethylaminopyridine.

[0040] (2) Preparation of polylactic acid: Weigh lactic acid and add it to a flask, raise the temperature to 120°C, remove water for 60min at a pressure of 60kPa, add catalyst under nitrogen protection, raise the temperature to 170°C at 3kPa, and react for 8h. After the reaction, add acetone to dissolve the product, then pour it into a large amount of deionized water to precipitate polylactic acid, wash it three times, and dry it in vacuum at 40°C for 24 hours; the above catalyst is stannous c...

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Abstract

The invention provides a preparation method of a biodegradable intravascular stent material, and belongs to the technical field of medical materials, and the preparation method comprises the followingsteps: polymerizing gluconic acid and glycolic acid to obtain polygluconic acid-glycolic acid; obtaining polylactic acid through lactic acid polymerization; polymerizing polygluconic acid-glycolic acid and polylactic acid to obtain a poly (gluconic acid-glycolic acid)-polylactic acid copolymer. The polygluconic acid-glycolic acid is introduced into the polylactic acid, so that the hydrophilicityof the polylactic acid is improved, the brittleness of the polylactic acid is reduced, the self-degradability of the polylactic acid is weakened, and the biocompatibility of the polylactic acid is improved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a biodegradable vascular stent material. Background technique [0002] The mortality rate of cardiovascular diseases is higher than that of tumors and other diseases, accounting for more than 40% of the residents' disease deaths, and the prevalence and mortality of cardiovascular diseases are on the rise. In my country, cardiovascular diseases have been listed as a major public health question. Drug therapy and surgical treatment are traditional methods for treating cardiovascular and cerebrovascular diseases. Drug therapy refers to the treatment of cardiovascular and cerebrovascular diseases by reducing blood viscosity and improving blood fluidity with drugs, but the cycle of drug therapy is long, the effect is slow, and the treatment effect on severe patients is poor; surgical treatment mainly refers to coronary artery bypass surger...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G63/08C08G63/78A61L27/18A61L27/50A61L27/58
CPCA61L27/18A61L27/507A61L27/58C08G63/08C08G63/78C08G81/00
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司