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Manganese dioxide-coated drug-loaded mesoporous titanium dioxide nanoparticle, and preparation method and application thereof

A technology of mesoporous titanium dioxide and manganese dioxide is applied in the field of medical drugs, which can solve problems such as poor therapeutic effect, achieve the effects of low cost, good killing of tumor cells, and improvement of tumor hypoxic microenvironment

Inactive Publication Date: 2020-09-08
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Tumor has gradually become an important factor that threatens people's life and health. The commonly used treatment methods not only have poor therapeutic effect, but also have serious side effects

Method used

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  • Manganese dioxide-coated drug-loaded mesoporous titanium dioxide nanoparticle, and preparation method and application thereof
  • Manganese dioxide-coated drug-loaded mesoporous titanium dioxide nanoparticle, and preparation method and application thereof
  • Manganese dioxide-coated drug-loaded mesoporous titanium dioxide nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Mesoporous Titanium Dioxide Nanoparticles

[0032] Titanium dioxide was prepared by hydrothermal method. At room temperature, drop 1ml of tetrabutyl titanate into 15ml of glacial acetic acid, and make it fully mix with glacial acetic acid. Next, 0.5 ml of deionized water was quickly added to initiate the hydrolysis of tetrabutyl titanate, and the rotating speed of the magnetic stirring was increased. The reaction lasted for 10 minutes, and the solution turned milky white. Transfer the solution to a stainless steel reaction kettle lined with polytetrafluoroethylene, place the reaction kettle in an oven at 150°C for 12 hours, cool to room temperature naturally, collect the precipitate by centrifugation, wash with deionized water three times, and obtain mesoporous titanium dioxide nanoparticles .

Embodiment 2 2

[0033] Example 2 Preparation of drug-loaded mesoporous titanium dioxide nanoparticles coated with manganese dioxide

[0034] Weigh 10 mg of mesoporous titanium dioxide nanoparticles, ultrasonically disperse in a water bath, add 50 mg of potassium permanganate under dark conditions, stir for 5 min to fully mix, then add 1 ml of polyallylamine hydrochloride solution (50 mg), and continue stirring for 10 min , centrifuged, washed three times, and then freeze-dried to obtain mesoporous titanium dioxide nanoparticles coated with manganese dioxide. Weigh 10 mg of manganese dioxide-coated mesoporous titanium dioxide nanoparticles and 100 mg of L-arginine, fully dissolve and disperse them in deionized water, keep stirring at room temperature for 12 h, and centrifuge to collect the precipitate.

Embodiment 3 2

[0035] Example 3 Preparation of drug-loaded mesoporous titanium dioxide nanoparticles coated with manganese dioxide

[0036] Weigh 10 mg of mesoporous titanium dioxide nanoparticles, ultrasonically disperse in a water bath, add 50 mg of potassium permanganate under dark conditions, stir for 5 min to fully mix, then add 1 ml of polyallylamine hydrochloride solution (100 mg), and continue stirring for 20 min , centrifuged, washed three times, and then freeze-dried to obtain mesoporous titanium dioxide nanoparticles coated with manganese dioxide. Weigh 10 mg of manganese dioxide-coated mesoporous titanium dioxide nanoparticles and 100 mg of L-arginine, fully dissolve and disperse them in deionized water, keep stirring at room temperature for 12 h, and centrifuge to collect the precipitate.

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Abstract

The invention belongs to the field of medical drugs, and particularly relates to a manganese dioxide coated drug-loaded mesoporous titanium dioxide nanoparticle, and a preparation method and application thereof. The preparation method of the nanoparticles comprises the following steps: firstly, preparing mesoporous titanium dioxide by utilizing a solvothermal method and controlling the reaction temperature and time, then wrapping a manganese dioxide shell layer by utilizing a redox reaction of potassium permanganate, and finally loading a drug through electrostatic adsorption. The nanoparticlehas the advantages of low cost, good stability, good biocompatibility and the like, active oxygen and NO can be generated under action of in-vitro ultrasound, and combined application of sonodynamictherapy and NO therapy is achieved. Peroxynitrite with higher cytotoxicity can be further generated by the active oxygen and NO, and the tumor killing effect is enhanced.

Description

technical field [0001] The invention belongs to the field of medical medicine, and in particular relates to a manganese dioxide-wrapped drug-loaded mesoporous titanium dioxide nanoparticle and a preparation method and application thereof. Background technique [0002] Tumor has gradually become an important factor that threatens people's life and health. The commonly used treatment methods not only have poor therapeutic effect, but also have serious side effects. Therefore, there is an urgent need to develop safer and more effective treatments. [0003] Sonodynamic therapy is a new type of tumor treatment method, mainly through the synergy of ultrasound and sound sensitizers. Ultrasound can penetrate deep tissue and excite the sonosensitizer that reaches the tumor site, and the sonosensitizer transfers energy to the surrounding oxygen molecules to generate reactive oxygen species, including singlet oxygen ( 1 O2), hydroxyl radicals (OH) and superoxide anion (O 2 - ), the...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K31/198A61K41/00A61P35/00
CPCA61K9/5115A61K31/198A61K41/0033A61P35/00A61K2300/00
Inventor 张良珂肖琪
Owner CHONGQING MEDICAL UNIVERSITY
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