Unlock instant, AI-driven research and patent intelligence for your innovation.

Short-chain peptide composition and application thereof in skin protection

A technology of skin protection and composition, applied in the field of short-chain peptide composition, which can solve the problems of skin repair, wound healing and protection of skin dryness and damage, so as to increase skin moisture and elasticity, repair burn wounds, and promote skin proliferative effect

Active Publication Date: 2020-09-08
PRO SUNFUN BIOTECH RES & DEV CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although peptides have been added to cosmetics, there are few reports on promoting wounded skin repair, wound healing and protecting dry skin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Short-chain peptide composition and application thereof in skin protection
  • Short-chain peptide composition and application thereof in skin protection
  • Short-chain peptide composition and application thereof in skin protection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. The short-chain peptide composition promotes the migration of epidermal cells and skin repair

[0024] In this example, the artificial scratching method is used, and the quantitative and qualitative data obtained are used to analyze the migration performance-repair of the short-chain peptide composition of the present invention on epithelial cells. Cell scratch test (Wound Healing) is a simple in vitro test method for studying cell migration / tumor invasion, which artificially creates a void on the confluent monolayer of cells when the cells grow to confluence into a monolayer state area, called a "scratch". Cells at the edge of the scratch gradually move into the empty space, allowing the "scratch" to heal. Disruption of the integrity of epidermal cells by mechanical means produces a realistic model, and microscopic techniques are ideal for studying epithelial cell migration.

[0025] The human immortalized epidermal cells (HaCaT) used in this example are a...

Embodiment 2

[0033] Example 2. Short-chain peptide composition promotes wound repair and healing

[0034] excision of the skin test

[0035] After the hair removal of the SD rats’ skin, a real circle of NT$5 was given, and the skin above the dermis was removed with a scalpel to cause skin damage (total damage). The experimental SD rats’ skin was first sterilized with betadine; Gel smear wipe. Apply AE250 gel and wipe once on the first day. Give AE250 gel (4 times / day) the next day, and AE250 gel is smeared and wiped for 7 days. Measure the area enclosed by the outermost perimeter of the wound. Use cellophane to actually measure the scab area of ​​the wound, then draw the area of ​​the cellophane with a cardboard, and finally weigh the cardboard as the area of ​​the wound.

[0036] The result is as figure 2 It can be seen that after applying and wiping AE250 gel in the excision skin experiment, compared with the injury group without drug treatment, AE250 can indeed significantly and g...

Embodiment 3

[0040] Example 3. The short-chain peptide composition increases skin moisturizing and elasticity

[0041] This example tests the effect of the short-chain peptide of the present invention on moisturizing and increasing skin elasticity. In this example, using the SG-S TSII skin detector (digital microscopic image analysis system, ARAM, New Taipei City, Taiwan) purchased from Hefengchun Industrial Co., Ltd., through the probe, the items to be tested are carried out. After testing, the obtained data can be quantified to know the condition of your skin.

[0042] The more water content in the stratum corneum of the skin, the easier it is to conduct electricity, and the higher the dielectric constant, so the higher the dielectric constant, the better the water retention. The unit used for its measurement is expressed in a.u.(arbitrary units), and the measurement range is from 0 to 120a.u. These values ​​are relative to the water content of the upper epidermis, where the value falls...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to a short-chain peptide composition and application thereof in skin protection. The short-chain peptide composition disclosed by the invention has the effects of promoting skinproliferation, repairing and healing wounds, moistening and moisturizing skins, and increasing skin elasticity.

Description

technical field [0001] The present invention relates to a short-chain peptide composition with skin protection effect. More particularly, the present invention relates to a short-chain peptide comprising one or more oligopeptides whose structure is a combination of 5-10 amino acids selected from serine (Serine) and lysine (Lysine) and other amino acids. The peptide composition has the effects of promoting skin proliferation, wound repair and healing, moisturizing and increasing skin elasticity. Background technique [0002] The skin is the human body's natural barrier against external environmental aggression, and has a certain protective effect on external stimuli, which is due to the protective effect of the skin's dense stratum corneum. But it also blocks the nutritional ingredients of cosmetics on the skin surface. Nutrients need to penetrate through the stratum corneum cell membrane to enter the dermis. Only a small amount of macromolecules and fat-soluble substances c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/08A61P17/02A61P17/00A61K8/64A61Q19/00
CPCA61K38/08A61P17/02A61P17/00A61K8/64A61Q19/00A61K2300/00
Inventor 侯建维李英中贾铜安戴瑞凡
Owner PRO SUNFUN BIOTECH RES & DEV CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com