Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sandwich structure molecularly imprinted sers substrate and preparation method and application thereof

A molecular imprinting, sandwich technology, applied in chemical instruments and methods, analytical materials, other chemical processes, etc., can solve the problems of single, can not be fixed, ready-to-use, etc., to improve SERS effect, enhance SERS effect, reduce The effect of background noise

Active Publication Date: 2021-03-30
SOUTH CHINA AGRI UNIV
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when SERS emphasizes the signal enhancement effect of the analyte, it ignores the poor selectivity of the analyte in SERS. When the analyte is a complex mixture or the concentration in the system is very low, the SERS measurement is susceptible to interference from impurities.
[0004] The existing Raman spectroscopy detection methods for hypoglycemic drugs in health products have the following disadvantages: (1) Most of them can only realize the detection of a single sample, and different detection methods need to be used for different targets; The characteristics of gold nanoparticles or silver nanoparticles are easy to be inactivated, and they often need to be prepared and used immediately, and the detection results are not stable, because the Raman detection intensity depends on the distance between the nanoparticles and the target molecule, and the added nanoparticles will randomly distribution, cannot be fixed
The above defects make Raman spectroscopy subject to certain limitations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sandwich structure molecularly imprinted sers substrate and preparation method and application thereof
  • Sandwich structure molecularly imprinted sers substrate and preparation method and application thereof
  • Sandwich structure molecularly imprinted sers substrate and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The invention provides a sandwich structure molecularly imprinted SERS substrate for detecting biguanide hypoglycemic drugs in health care products and a preparation method thereof. The preparation method includes: using p-aminothiophenol as an "intermediate agent" to polymerize gold nanoparticles on the surface of graphene oxide; It is a functional monomer, and ethylene glycol dimethacrylate is used as a cross-linking agent to polymerize the molecularly imprinted layer. Graphene oxide provides good binding sites for molecularly imprinted polymers, while molecularly imprinted polymers have selective adsorption capabilities, and gold nanoparticles play a role in SERS enhancement. Compared with the existing detection technology, the present invention obtains a sandwich structure molecularly imprinted SERS substrate MIP@Au-GO by synthesizing polymers step by step. The synthesis method of the substrate is simple, the size and number of the nano-gold particles and the dista...

Embodiment 1 3

[0060] Example 1 Preparation of Sandwich Structure Molecularly Imprinted SERS Substrate MIP@Au-GO

[0061] refer to Figure 1 to Figure 6 , the present invention provides a molecularly imprinted SERS substrate with a sandwich structure for detecting biguanide hypoglycemic drugs in health products. The molecularly imprinted SERS substrate is composed of gold nanoparticles, p-aminothiophenol, graphene oxide, metformin hydrochloride, Methacrylic acid and ethylene glycol dimethacrylate are polymerized to form a sandwich structure polymer, the gold nanoparticles are modified with p-aminothiophenol, and the graphene oxide and the modified gold nanoparticles Combined to obtain an Au-GO composite, the synthetic imprinting layer of metformin hydrochloride, methacrylic acid and ethylene glycol dimethacrylate is polymerized outside the Au-GO composite, and the molecularly imprinted SERS substrate is obtained after metformin hydrochloride is eluted MIP@Au-GO.

[0062] In this example, ...

Embodiment 2 3

[0083] Example 2 Preparation of Sandwich Structure Molecularly Imprinted SERS Substrate MIP@Au-GO

[0084] The invention provides a molecularly imprinted SERS substrate with a sandwich structure for detecting biguanide hypoglycemic drugs in health care products. The molecularly imprinted SERS substrate is composed of gold nanoparticles, p-aminothiophenol, graphene oxide, metformin hydrochloride, formazan Acrylic acid and ethylene glycol dimethacrylate are polymerized to form a sandwich structure polymer, the gold nanoparticles are modified with p-aminothiophenol, and the graphene oxide is combined with the modified gold nanoparticles , Au-GO composites were obtained, and the synthetic imprinting layers of metformin hydrochloride, methacrylic acid and ethylene glycol dimethacrylate were polymerized outside the Au-GO composites, and the molecularly imprinted SERS substrate MIP was obtained after metformin hydrochloride was eluted. @Au-GO.

[0085] The molecularly imprinted SERS...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a sandwich structure molecularly imprinted SERS substrate, and a preparation method and application thereof. The preparation method comprises the following steps: polymerizing gold nanoparticles on the surface of graphene oxide by using p-aminothiophenol as an intermediate agent; and polymerizing an upper molecular imprinting layer on the compound by taking a biguanide hypoglycemic agent as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The graphene oxide provides a good binding site for the molecularly imprinted polymer, the molecularly imprinted polymer has selective adsorption capacity, and the gold nanoparticles play a role in SERS enhancement. Compared with an existing detection technology, the preparation method has the following advantages: the sandwich structure molecularly imprinted SERS substrate MIP@Au-GO is obtained by adopting a mode of synthesizing polymers step by step, thesynthesis method is simple, the size, the number and the distance between the gold nanoparticles and target molecules are controllable, the adsorption efficiency is high, the detection effect is stable, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of health product detection, and in particular relates to a molecularly imprinted SERS substrate with a sandwich structure and a preparation method and application thereof. Background technique [0002] Biguanide hypoglycemic drugs mainly include metformin hydrochloride and phenformin hydrochloride, which have the advantages of significant efficacy on diabetes and low price. The state expressly prohibits the addition of drugs in health products, but some unscrupulous businesses indiscriminately add biguanide hypoglycemic drugs and other drugs to health products in pursuit of their own interests, seriously endangering people's health. There are many reports on the analysis of the detection of biguanides, mainly including high-performance liquid chromatography (HPLC) or methods combined with other techniques, electrochemical sensing methods, and fluorescence spectroscopy. Although these methods have their own...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08F2/44C08J9/28B01J20/285B01J20/28B01J20/26G01N21/64C08L35/02
CPCB01J20/268B01J20/28014B01J20/285C08F2/44C08J9/28C08J2335/02C08F222/102G01N21/6428G01N2021/6432C08F220/06
Inventor 徐小艳卢瑞琴田兴国王时玉戚镇科
Owner SOUTH CHINA AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com