External traditional Chinese medicine composition and gel plaster for fever abatement of children, and preparation method of external traditional Chinese medicine composition and gel plaster
A composition and technology of traditional Chinese medicine, applied in the directions of antipyretics, drug combinations, pharmaceutical formulations, etc., can solve the problems of short half-life, first-pass effect, imperfection, etc., and achieve the effects of large drug load and convenient use.
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[0034] The preparation of traditional Chinese medicine composition, comprises Bupleurum aromatic water and extract two parts: the preparation method of composition 1 and composition 3 in table 1 is:
[0035] (1) Preparation of Bupleurum aromatic water: Take the Bupleurum of combination 1 or combination 3 in Table 1, add 6 times the mass of deionized water, soak at 40°C for 12 hours, then distill, collect twice the mass of Bupleurum Distillate; after the distillate is cooled to room temperature, add 2% pure propylene glycol to the distillate and mix evenly to obtain Bupleurum aromatic water; the distilled Bupleurum medicinal residue is set aside.
[0036] (2) Preparation of extract: the Bupleuri herb residue in step (1), filtered under normal temperature and pressure, then take the filter residue, add gardenia and raw rhubarb in the amount of combination 1 or combination 3 in Table 1; add the total mass of crude drug 8 Double the amount of 80% volume percentage ethanol; reflux ...
Embodiment 1
[0042] Step (1): Dissolve 70 parts of tartaric acid in a mixture of 3360 parts of deionized water and 1600 parts of Bupleurum aromatic water, then add 200 parts of polyvinylpyrrolidone K90, 50 parts of carbomer 934, and 50 parts of carbomer 941 , placed for 12 hours to fully swell polyvinylpyrrolidone K90, carbomer 934, and carbomer 941; mixture 1 was obtained.
[0043] Step (2): Take 800 parts of sodium polyacrylate NP700, 70 parts of aluminum glycylate, 2500 parts of glycerin, 250 parts of propylene glycol, and 250 parts of sorbitol, mix them at a speed of 120 rpm for 15 minutes, then add 800 parts of extract and the mixture into it , continue stirring at a speed of 240rpm for 20min, and coat at room temperature with a thickness of 1mm. Put it in a constant temperature and humidity environment at 25° C. and 60% RH for 12 hours, cut it into certain specifications, put it into an aluminum foil bag and seal it, and then get the gel plaster of the traditional Chinese medicine co...
Embodiment 2
[0046] Step (1): Dissolve 50 parts of tartaric acid in a mixture of 4000 parts of deionized water and 1400 parts of Bupleurum aromatic water, then add 300 parts of polyvinylpyrrolidone K90, 25 parts of carbomer 934, and 25 parts of carbomer 941 , placed for 24 hours to fully swell polyvinylpyrrolidone K90, carbomer 934, and carbomer 941; mixture 1 was obtained.
[0047] Step (2): Take 700 parts of sodium polyacrylate NP700, 50 parts of aluminum glycylate, 2000 parts of glycerin, 250 parts of propylene glycol, and 500 parts of sorbitol, and mix them at a speed of 120 rpm for 15 minutes, then add 700 parts of the extract and the mixture into it , continue stirring at a speed of 240rpm for 20min, and coat at room temperature with a thickness of 1mm. Put it in a constant temperature and humidity environment at 25° C. and 60% RH for 12 hours, cut it into certain specifications, put it into an aluminum foil bag and seal it, and then get the gel plaster of the traditional Chinese med...
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