External traditional Chinese medicine composition and gel plaster for fever abatement of children, and preparation method of external traditional Chinese medicine composition and gel plaster

A composition and technology of traditional Chinese medicine, applied in the directions of antipyretics, drug combinations, pharmaceutical formulations, etc., can solve the problems of short half-life, first-pass effect, imperfection, etc., and achieve the effects of large drug load and convenient use.

Pending Publication Date: 2020-09-18
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, Western medicine mostly uses antipyretic and analgesic drugs and non-steroidal anti-inflammatory drugs for treatment. Although they have a certain antipyretic effect, they also have problems such as first-pass effect, short half-life, and large adverse reactions. For example, aspirin can cause gastric Intestinal irritation symptoms, asthma or skin rash, etc., limit its scope of application

Method used

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  • External traditional Chinese medicine composition and gel plaster for fever abatement of children, and preparation method of external traditional Chinese medicine composition and gel plaster
  • External traditional Chinese medicine composition and gel plaster for fever abatement of children, and preparation method of external traditional Chinese medicine composition and gel plaster
  • External traditional Chinese medicine composition and gel plaster for fever abatement of children, and preparation method of external traditional Chinese medicine composition and gel plaster

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] The preparation of the traditional Chinese medicine composition includes two parts: Bupleurum fragrant water and extract: The preparation methods of composition 1 and composition 3 in Table 1 are:

[0035] (1) Preparation of Bupleurum aromatic water: Take the amount of Bupleurum in combination 1 or 3 in Table 1, add 6 times the mass of deionized water, immerse it at 40℃ for 12h, and then distill to collect twice the mass of Bupleurum Distillate: After the distillate is cooled to room temperature, add 2% pure propylene glycol of the distillate by mass, and mix it evenly to obtain Bupleurum spp. aromatic water; the distilled Bupleurum dregs is ready for use.

[0036] (2) Preparation of extract: Bupleurum dregs in step (1), filtered under normal temperature and pressure, take the filter residue, add gardenia and raw rhubarb in the amount of combination 1 or combination 3 in Table 1; add the total mass of crude drug 8 80% volume percent ethanol; reflux extraction for 0.5h, the r...

Example Embodiment

[0041] Example one

[0042] Step (1): Dissolve 70 parts of tartaric acid in a mixture of 3360 parts of deionized water and 1600 parts of Bupleurum aromatic water, and then add 200 parts of polyvinylpyrrolidone K90, 50 parts of carbomer 934, and 50 parts of carbomer 941 , Place for 12h, make polyvinylpyrrolidone K90, Carbomer 934, Carbomer 941 fully swell; get mixture one.

[0043] Step (2): Take 800 parts of sodium polyacrylate NP700, 70 parts of glycerol, 2500 parts of glycerol, 250 parts of propylene glycol, and 250 parts of sorbitol and mix them. After stirring at 120rpm for 15 minutes, add 800 parts of extract and the mixture into it. , Stirring at 240rpm speed for 20min, coating at room temperature, coating thickness is 1mm. Place it in a constant temperature and humidity environment of 25° C. and 60% RH for 12 hours, cut into certain specifications, and put it in an aluminum foil bag for sealing to obtain a Chinese medicine composition gel plaster for antipyretic external us...

Example Embodiment

[0045] Example two

[0046] Step (1): Dissolve 50 parts of tartaric acid in a mixture of 4000 parts of deionized water and 1400 parts of Bupleurum aromatic water, and then add 300 parts of polyvinylpyrrolidone K90, 25 parts of Carbomer 934, 25 parts of Carbomer 941 , Placed for 24h to fully swell polyvinylpyrrolidone K90, carbomer 934, and carbomer 941; a mixture is obtained.

[0047] Step (2): Take 700 parts of sodium polyacrylate NP700, 50 parts of aluminum glycolate, 2000 parts of glycerol, 250 parts of propylene glycol, and 500 parts of sorbitol and mix them. After stirring at 120 rpm for 15 minutes, add 700 parts of extract and the mixture into it. , Stirring at 240rpm speed for 20min, coating at room temperature, coating thickness is 1mm. Place it in a constant temperature and humidity environment of 25° C. and 60% RH for 12 hours, cut into certain specifications, and put it in an aluminum foil bag for sealing to obtain a Chinese medicine composition gel plaster for antipyre...

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Abstract

The invention discloses an external traditional Chinese medicine composition and gel plaster for fever abatement of children, and a preparation method of the external traditional Chinese medicine composition and the gel plaster, and belongs to the technical field of traditional Chinese medicines. The external traditional Chinese medicine composition for fever abatement of children comprises radixbupleuri, fructus gardeniae and radix et rhizoma rhei. The preparation method of the external traditional Chinese medicine composition for fever abatement of children comprises two parts of radix bupleuri aromatic water and extract. The gel plaster comprises the following components: radix bupleuri aromatic water, extract, sodium polyacrylate, dihydroxyaluminium aminoacetate, tartaric acid, polyvinylpyrrolidone and other auxiliary materials. The preparation method of the gel plaster comprises the following steps of mixing, standing and swelling, mixing and stirring, and coating. The gel plaster prepared by the invention can simultaneously exert the effects of traditional Chinese medicine compatibility and fever abatement and the physical cooling effect of the gel plaster; the drug loadingcapacity is high, the use is convenient, and a safe, effective and easy-to-accept preparation is provided for children suffering from exogenous fever.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for reducing fever in children, a gel plaster and a preparation method thereof. Background technique [0002] Fever in children is the most common symptom of respiratory diseases in pediatrics. It has the characteristics of rapid onset and rapid transmission. According to reports, it occurs an average of 6-7 times a year. In addition, about 10%-15% of children have more than 12 times a year. Complications such as convulsions and dehydration caused by high fever seriously endanger the health and life safety of children. [0003] At present, Western medicine mostly uses antipyretic and analgesic drugs and non-steroidal anti-inflammatory drugs for treatment. Although they have a certain antipyretic effect, they also have problems such as first-pass effect, short half-life, and large adverse reactions. For example, aspi...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/70A61K47/32A61K47/10A61P29/00
CPCA61K36/233A61K36/744A61K36/708A61K9/7061A61K47/10A61P29/00A61K2236/333
Inventor 章烨雯
Owner YULIN NORMAL UNIVERSITY
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