A kind of chitosan hemostatic powder and preparation method thereof

A technology of chitosan and hemostatic powder, which is applied in the field of biomedical materials, can solve the problems of poor process stability, uncertain lactic acid content, poor hemostatic effect, etc., and achieve the effects of simple preparation process, reduced production cost and good hemostatic effect.

Active Publication Date: 2022-04-22
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Domestic research on chitosan hemostatic powder is relatively late, and the hemostatic effect of prepared chitosan hemostatic powder is poor, and it cannot effectively stop bleeding from large arteries, and the amount of ethanol used in the preparation process is large, and the production cost is high
[0005] The publication number is CN106810624A, which discloses a preparation method of chitosan lactate. Chitosan and lactic acid ethanol solution react under stirring conditions. After the reaction, continue to use the lactic acid ethanol system by adding lactic acid. There is ethanol in the process. The consumption is large, the cost is high, the lactic acid ethanol system that continues to be used is impure, the lactic acid content is uncertain, and the process stability is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Adopt following method to prepare chitosan hemostatic powder:

[0030] (1) Weigh 100g of chitin, add it to 3000ml of 40% alkaline solution, and carry out deacetylation reaction at 50°C, and the reaction time is 5h;

[0031] (2) After the reaction, filter and wash the filter cake with purified water until neutral;

[0032] (3) blast drying to obtain chitosan weighing 76g;

[0033] (4) Add the chitosan prepared in the above steps to 700ml of ethanol solution containing 1% lactic acid and 0.12% lactic anhydride, and react for 2h under rotating conditions;

[0034] (5) After the reaction, rotate and vacuum dry at 40°C for 1 hour to obtain chitosan hemostatic powder. After testing, the lactic anhydride content was 1.27%.

Embodiment 2

[0036] Adopt following method to prepare chitosan hemostatic powder:

[0037] (1) Weigh 100g of chitin, add it to 2500ml of 55% alkaline solution, and carry out deacetylation reaction at 85°C, and the reaction time is 0.5h;

[0038] (2) After the reaction, filter and wash the filter cake with purified water until neutral;

[0039] (3) Blast drying to obtain chitosan weighing 73g;

[0040] (4) Add the chitosan prepared in the above steps to 600ml ethanol solution containing 2% lactic acid and 0.35% lactic anhydride, and react for 2h under rotating conditions;

[0041] (5) After the reaction, rotate and vacuum dry at 30° C. for 1.5 h to obtain chitosan hemostatic powder. After testing, the lactic anhydride content was 3.16%.

Embodiment 3

[0043] Adopt following method to prepare chitosan hemostatic powder:

[0044] (1) Weigh 100g of chitin, add it to 2200ml of alkaline solution with a concentration of 65%, and carry out deacetylation reaction at 70°C, and the reaction time is 2.5h;

[0045] (2) After the reaction, filter and wash the filter cake with purified water until neutral;

[0046] (3) blast drying to obtain chitosan weighing 74g;

[0047] (4) Add the chitosan prepared in the above steps to 620ml ethanol solution containing 3% lactic acid and 0.55% lactic anhydride, and react under rotation for 10min;

[0048] (5) After the reaction, spin vacuum drying at 55° C. for 0.5 h to obtain chitosan hemostatic powder. After testing, the content of lactic anhydride was 5.92%.

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Abstract

The invention provides a chitosan hemostatic powder and a preparation method thereof. The main component of the chitosan hemostatic powder is chitosan lactate, which contains 1% to 8% of lactic anhydride, and can realize anti-femoral artery within 3 minutes. effective hemostasis; the preparation process is simple, the product yield is high, the ethanol can be recycled, and the production cost is greatly reduced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a chitosan hemostatic powder and a preparation method thereof. Background technique [0002] Uncontrolled hemorrhage is the main cause of death on the battlefield. First aid for wounded soldiers as early as possible and control of hemorrhage become the best strategy to reduce the death of soldiers. [0003] Chitosan is a natural polymer biomaterial, a positively charged polysaccharide that can absorb negatively charged blood cells and promote blood coagulation. Chitosan's properties of hemostasis, biocompatibility, microbial degradability, and easy gel formation endow it with good performance as a hemostatic material. [0004] Domestic research on chitosan hemostatic powder is relatively late, and the prepared chitosan hemostatic powder has poor hemostatic effect and cannot effectively stop bleeding from large arteries, and the amount of ethanol used in the prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08C08B37/08
CPCA61L24/08C08B37/003A61L2400/04C08L5/08
Inventor 李素哲黄栋刘俊英于蕊孙丙辉张志宝张丽红史思饶
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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