Composite tendon adhesion preventing membrane and preparation method
An anti-adhesion film and tendon technology, which is applied in the direction of pharmaceutical formulations, conjugated artificial filaments, and fiber chemical characteristics, can solve problems such as overall material flexibility and mechanical strength, and achieve good hemostasis and antibacterial functions. Preparation The method is simple and the effect of increasing the service life
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Embodiment 1
[0038] The invention provides a composite tendon anti-adhesion film, the composite tendon anti-adhesion film is a chitosan-modified nano-fiber film, the nano-fiber film is loaded with collagen, and the collagen load is 5%.
[0039] The preparation steps of the above-mentioned composite tendon anti-adhesion film are as follows:
[0040] 1) Preparation of chitosan-modified nanofibrous membrane
[0041] Dissolve chitosan and cellulose acetate (the mass ratio of the two is 1:2) in a mixed solvent, stir evenly, and then stand for defoaming to obtain a solution concentration of 220-275g / L electrospinning solution. Then carry out electrospinning; obtain the nanofiber membrane modified by chitosan; the molecular weight of the chitosan is 2~50kDa;
[0042] The process conditions of the electrospinning are as follows: the voltage is 18-24kV, the distance from the needle tip to the drum is 10-15cm, and the solution flow rate is 0.5-1.0mL / h;
[0043] The mixed solvent is any two of trif...
Embodiment 2
[0058] The invention provides a composite tendon anti-adhesion film, the composite tendon anti-adhesion film is a chitosan-modified nanofiber film, the nanofiber film is loaded with collagen, and the collagen load is 6%. figure 2 Electron micrograph of the composite tendon anti-adhesion membrane prepared for this example.
[0059] The preparation steps of the above-mentioned composite tendon anti-adhesion film are as follows:
[0060] 1) Preparation of chitosan-modified nanofibrous membrane
[0061] Dissolve chitosan (molecular weight 2-50kDa) and cellulose acetate (the mass ratio of the two is 1:2) in a mixed solvent, stir evenly and let it stand for defoaming to obtain a solution with a concentration of 220-275g / L. Spinning solution, then electrospinning; Obtain chitosan-modified nanofibrous membrane;
[0062] The process conditions of the electrospinning are as follows: the voltage is 18-24kV, the distance from the needle tip to the drum is 10-15cm, and the solution flow...
Embodiment 3
[0068] The invention provides a composite tendon anti-adhesion film, the composite tendon anti-adhesion film is a chitosan-modified nanofiber film, the nanofiber film is loaded with collagen, and the collagen load is 9%.
[0069] The preparation steps of the above-mentioned composite tendon anti-adhesion film are as follows:
[0070] 1) Preparation of chitosan-modified nanofibrous membrane
[0071] Dissolve chitosan (molecular weight 2-50kDa) and cellulose acetate (the mass ratio of the two is 1:2) in a mixed solvent, stir evenly and let stand for defoaming to obtain a solution concentration of 220-275g / L electrospinning solution, then carry out electrospinning; Obtain the nanofibrous film of chitosan modification;
[0072] The process conditions of the electrospinning are as follows: the voltage is 18-24kV, the distance from the needle tip to the drum is 10-15cm, and the solution flow rate is 0.5-1.0mL / h;
[0073] The mixed solvent is any two of trifluoroacetic acid, formi...
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