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Method for degrading anti-inflammatory drug indometacin in water body by utilizing electron beam irradiation

A technology of electron beam irradiation and indomethacin, which is applied in the direction of water pollutants, chemical instruments and methods, light water/sewage treatment, etc., can solve the adverse effects of animals and human health, the removal rate is less than 20%, and it is difficult to Remove indomethacin and other problems, achieve the effect of low toxicity of degradation products, reduce treatment costs, and complete degradation

Pending Publication Date: 2020-09-29
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main sources of drugs in water are wastewater from the pharmaceutical industry, expired or remaining drugs, and human and animal excreta. Due to the large-scale production, use and discharge of indomethacin, it is widely present in various environmental matrices, such as wastewater, Surface water, tap water, sediment and even animals and plants, traditional biological treatment methods are difficult to remove indomethacin, and the removal rate of urban sewage treatment plants is less than 20%
The long-term accumulation of indomethacin in the environment will seriously affect the ecological balance of water bodies, and the accumulation in aquatic organisms will enter the human body through the food chain, causing long-term adverse effects on the health of animals and humans

Method used

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  • Method for degrading anti-inflammatory drug indometacin in water body by utilizing electron beam irradiation
  • Method for degrading anti-inflammatory drug indometacin in water body by utilizing electron beam irradiation
  • Method for degrading anti-inflammatory drug indometacin in water body by utilizing electron beam irradiation

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Effect test

Embodiment 1

[0024] In the present embodiment, a method utilizing electron beam irradiation to degrade indomethacin in water comprises the steps:

[0025] a. First weigh the anti-inflammatory drug indomethacin at room temperature, and dissolve it with ultrapure water to obtain an indomethacin solution with a concentration of 150, 200, 250, or 300 μmol / L; add sulfuric acid or hydrogen to the above solution Sodium, adjust the initial pH of the simulated solution to be 7, as the simulated solution;

[0026] b. Transfer 15mL of the simulated solution prepared in the main step a and seal it in a transparent polyethylene irradiation pouch. The thickness of the liquid in the polyethylene irradiation pouch is not more than 0.5cm. The polyethylene irradiated pouch is placed under the electron beam generated by the electron beam accelerator for irradiation degradation treatment. Indomethacin was irradiated at room temperature with an electron beam energy of 1.6 MeV, an electron beam current of 0.5 ...

Embodiment 2

[0032] This embodiment is basically the same as Embodiment 1, especially in that:

[0033] In the present embodiment, a method utilizing electron beam irradiation to degrade indomethacin in water comprises the steps:

[0034] a. First, weigh the anti-inflammatory drug indomethacin at room temperature, and dissolve it in ultrapure water to obtain an indomethacin solution with a concentration of 300 μmol / L; add sulfuric acid or sodium hydroxide to the above solution to adjust the initial value of the simulated solution. pH, so that the initial pH of the indomethacin solution was 5, 7, 9, and 10, respectively, as a simulated solution;

[0035] b. Transfer 15mL of the simulated solution prepared in step a and seal it in a transparent polyethylene irradiation pouch. The thickness of the liquid in the polyethylene irradiation pouch is not more than 0.5cm. The ethylene irradiated pouch is placed under the electron beam generated by the electron beam accelerator for irradiation degra...

Embodiment 3

[0040] This embodiment is basically the same as the previous embodiment, and the special features are:

[0041] In the present embodiment, a method for degrading indomethacin in water by electron beam irradiation, comprising the steps:

[0042] a. First, weigh the anti-inflammatory drug indomethacin at room temperature, dissolve it in ultrapure water to prepare an indomethacin solution with a concentration of 300 μmol / L; add sulfuric acid or sodium hydroxide to the above solution to adjust the initial value of the simulated solution pH is 7 and H is added to the solution 2 O 2 , so that the H in the above solution 2 O 2 The molar concentrations were 1mmol / L, 10mmol / L, 50mmol / L, and 100mmol / L, respectively, as simulated solutions;

[0043] b. Transfer and encapsulate 15 mL of the simulated solution prepared in step a in a transparent polyethylene irradiated pouch. The thickness of the liquid in the polyethylene irradiated pouch is not greater than 0.5 cm. The ethylene irra...

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Abstract

The invention discloses a method for degrading an anti-inflammatory drug indometacin in a water body by utilizing electron beam irradiation, and belongs to the field of water treatment and environmental protection. The water decomposition is excited by electron beam irradiation to generate .OH and H. with high reactivity, and indometacin is degraded under the oxidation and reduction actions, so that the method is a simple and efficient pollutant removal method. An indometacin solution with a certain concentration is subjected to irradiation treatment under an electron beam, the irradiation dose is 0.5-3 kGy, the removal effect is improved along with the increase of the dose, the method conforms to quasi-primary dynamics, and indometacin can be completely removed in a short time. 1-100 mmol / L of hydrogen peroxide is added into the solution, so that irradiation degradation of indometacin can be promoted, and the economy of irradiation treatment of pollutants is improved. The method is high in removal efficiency, high in reaction rate, simple and convenient to operate, free of secondary pollution and wide in applicability.

Description

technical field [0001] The invention relates to a treatment method for refractory drug waste water, in particular to a treatment method for anti-inflammatory drug waste water, which belongs to the technical field of waste water treatment. Background technique [0002] Indomethacin is an effective non-steroidal anti-inflammatory drug, which is widely used for its excellent anti-inflammatory and antipyretic effects. Indomethacin is relatively stable in the natural environment and can exist in the environment for a long time. The main sources of drugs in water are wastewater from the pharmaceutical industry, expired or remaining drugs, and human and animal excreta. Due to the large-scale production, use and discharge of indomethacin, it is widely present in various environmental matrices, such as wastewater, In surface water, tap water, sediments and even in animals and plants, traditional biological treatment methods are difficult to remove indomethacin, and the removal rate ...

Claims

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Application Information

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IPC IPC(8): C02F9/08C02F1/30C02F101/30
CPCC02F1/305C02F1/66C02F2305/023C02F2101/30
Inventor 周伟张芝勃邹齐张俊云杨晓徐刚
Owner SHANGHAI UNIV
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