45results about How to "No harsh reaction conditions" patented technology

The invention discloses a synthesizing method of a tetrabromobisphenol A dual (2,3-dibromo-2-methyl propyl) ether. The method comprises the following steps: adding tetrabromobisphenol and an alkali into water; stirring until completely dissolving; then carrying out the primary heat preservation; regulating the pH value; adding a dispersing agent; dropwise adding methylallyl chloride and carrying out the secondary heat preservation; after carrying out the primary aftertreatment, obtaining an intermediate product; adding the intermediate product into an organic solvent; stirring until the intermediate product is completely dissolved, and then dropwise adding the bromine; refluxing and carrying out the tertiary heat preservation; and after finishing the tertiary heat preservation, obtaining a product by carrying out the secondary aftertreatment. The method is simple; the adopted solvent can be recycled and reused; the temperature of the bromination reaction is low; the reaction condition is moderate and is easy to control; the energy consumption during the production is low; and the strict reaction conditions are not required by all steps, so that the method is favorable for industrial production. The tetrabromobisphenol A dual (2,3-dibromo-2-methyl propyl) ether as the product is high in yield, good in quality, good in heat stability and high in content, thereby lightening the environmental-protection stress. In addition, the tetrabromobisphenol A dual (2,3-dibromo-2-methyl propyl) ether is high in purity, low in impurity content and free of generating 'three wastes' and environmental pollution.

The invention discloses application of a Uio-66 / polyaromatic composite material in treating wastewater containing hexavalent Cr. The Uio-66 / polyaromatic composite material is characterized in that anadsorbent is dissolved into an aqueous solution and an aromatic amine monomer is formed on the surface of Uio-66 through an in situ chemical oxidation polymerization method. The prepared Uio-66 / polyaromatic composite material has the advantages of simple synthesis process, low cost, high yield, good removal effect on Cr(VI) in water and no secondary pollution. At room temperature, the maximum adsorption capacity of the adsorbent can reach 263.69mg / g, and the removal rate can reach 99 percent or above which is higher than that of non-composite Uio-66 and majority reported chromium adsorption materials. Acidic wastewater containing Cr(VI) is treated by adopting the method disclosed by the invention; the method has the characteristics of simple process, convenience in operation, good economicbenefits and the like.

The invention provides a novel method for preparing an external-use antibiotic drug retapamulin. The novel method comprises the following steps: taking tiamulin as a starting raw material, and preparing retapamulin through five-step solid chemical reaction and a refining process. According to the novel method provided by the invention, quality of the starting raw material is controllable, so that the novel method is suitable for novel drug development and declaration. The novel method is simple to operate, is controllable in condition, is low in preparation cost, is convenient for industrial production, and is significant innovation for a retapamulin synthesis method.

The present invention relates to a kind of method for preparing 2-amino-2-methyl-1-propanol, comprising the following steps: 1) 2-chloropropane and sodium cyanide react to generate 2-methylpropionitrile; 2) 2-methylpropionitrile 2,2-dimethyl-3-hydroxypropionitrile undergoes an aldol condensation reaction with formaldehyde; 3) 2,2-dimethyl-3-hydroxypropionitrile undergoes a hydrolysis reaction to generate 2,2-dimethyl 4) 2,2-dimethyl-3-hydroxypropionamide undergoes Hofmann degradation reaction to generate 2-amino-2-methyl-1-propanol. The raw materials in each step of the method are cheap and easy to obtain, the reaction process is simple, there are no harsh reaction conditions, the cost advantage is obvious, the yield is high, the pollution is low, and the product is easy to purify.

The invention belongs to the field of pharmaceutical chemistry, and more specifically relates to sitagliptin which is used for treatment of type 2 diabete and an intermediate of sitagliptin. The invention provides a compound represented by formula II. The invention also discloses applications of the compound which is represented by formula II in preparation of sitagliptin. Sitagliptin is obtained by catalytic hydrogenation of the compound. The method of the invention can be used to produce sitagliptin simply and conveniently, and is low in cost, and is easy to industrialize.

The invention discloses an anti-sulfur-poisoning platinum catalyst and a preparation method thereof, the preparation method comprises the following steps: A, a carrier material is dispersed into a 0#solvent, amino alkoxyl silane is added for mixing, an acid catalyst and water are added, and the mixture is in reaction to obtain a modified carrier material; B, the solvent, epithio-heterocyclic monomers and modified platinum dichloride (II) are mixed and stirred, an acid stabilizer and an acid catalyst are added, and water is added dropwise for reaction to obtain a modified platinum catalyst; C,under the condition that the inert gas is fed, the solvent, the modified carrier material and a modified platinum catalyst solution are mixed, warming reaction is conducted, reaction is performed under the vacuumizing condition, then the temperature is reduced to 0 DEG C sharply and standing is performed, and the anti-sulfur-poisoning platinum catalyst is obtained after separation. According to the platinum catalyst, the catalytic activity and the stability are improved remarkably, the poisoning effect is reduced greatly when the platinum catalyst is used in synthesis of sulfur-containing silicone oil and silicon resin, and the anti-poisoning effect is remarkable.

The invention discloses a Uio-66 / polyaromatic amine composite material with a core-shell structure as well as a preparation method and application thereof. The preparation method comprises the following steps: dispersing Uio-66 in an aqueous solution; adding an aromatic amine monomer and a surfactant, and stirring for 0.5-24 h for sufficient contact; dropwise adding a sulfate aqueous solution to initiate a polymerization reaction, and continuously stirring for 3-24 h; performing centrifugal separation, and washing to obtain a Uio-66 / polyaromatic amine composite material. The specific surface area of the composite material reaches 319.77m<2> / g, thereby effectively increasing the specific surface area of polyaromatic amine; moreover, the surface of Uio-66 is subjected to amination modification successfully. The method disclosed by the invention can be used for efficiently preparing the Uio-66 / polyaromatic amine composite material, and is economical and effective and easy to operate, andthus has a broad application prospect in the technical field of water treatment.

The invention discloses a preparation method of hexahydric dicycloguanidine based on guanidine hydrochloride. The preparation method of the hexahydric dicycloguanidine comprises the following steps of: (1), synthesizing TBD (Chloropropyl Methyl Dichlorosilane) by utilizing guanidine hydrochloridel; (2), synthesizing hexahydric dicycloguanidine by utilizing TBD methylation. The preparation method disclosed by the invention is less in synthesis steps, simple and easy to implement, free of severe reaction conditions, capable of adopting a crystallization-distillation purifying method and easy to realize industrial production. The using reagents are low-toxic or non-toxic, and the environment pollution is less. The yields of the two steps are more than 85% and the yields are high. The used materials and reagents are cheap, so that the cost is low.

The invention discloses a method for synthesizing tetrabromophthalic anhydride diol, comprising the following steps: stirring tetrabromophthalic anhydride and diethylene glycol evenly, adding a catalyst, and under the protection of protective gas, heating up to the reaction temperature for the first time After the reaction is completed, an organic solvent is added to dissolve the above-mentioned reaction materials, propylene oxide is added after the temperature is lowered, the temperature is raised for the second time to carry out a heat preservation reaction, and after the reaction is completed, hot filtration is performed, and then the organic solvent is distilled off to obtain the product. The solvent used in the reaction of the method of the invention can be re-evaporated and applied mechanically, the process is simple, the reaction temperature is low, the reaction conditions are mild, easy to control, and the production energy consumption is low, no harsh reaction conditions are required in each step, and industrial production is easy, and the product yield is high. , good thermal stability, high content, good product quality, and there is no generation of three wastes, there is no problem of environmental pollution.