Differential ion mobility spectrometry-mass spectrometry combined device based on series connection of grounding electrode plates and application

A technology of differential ion migration and grounding plates, which is applied in the field of analysis and detection, can solve the problems of reducing the resolution of the system, and achieve the effects of improving overall performance, resolution, and convenient operation

Active Publication Date: 2020-10-02
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies have shown that this design significantly reduces system resolution

Method used

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  • Differential ion mobility spectrometry-mass spectrometry combined device based on series connection of grounding electrode plates and application
  • Differential ion mobility spectrometry-mass spectrometry combined device based on series connection of grounding electrode plates and application
  • Differential ion mobility spectrometry-mass spectrometry combined device based on series connection of grounding electrode plates and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Single-stage ion mobility-mass spectrometry devices such as figure 1 As shown, the lengths of the grounding plates are 20mm and 40mm respectively, the channel size of the differential migration spectrum is 40-80mm×20mm×1.4mm (length×width×channel width), the material of the migration outer cavity is polyetheretherketone, and the electrode The material is C316 stainless steel, and the width of the two-stage interface is 5mm. Among them, 1-nano-electrospray ion source sampling device; 2-closed ion source cavity; 3-ion source auxiliary gas interface I; 4-gas cylinder; Dopant addition device; 6- ion source auxiliary gas interface II; 7- migration outer chamber Ⅰ; 8- first electrode plate; 9- migration outer chamber II; 10- second electrode; 11- insulator; 12- mass spectrometry transmission capillary ; 13-auxiliary gas; 14-ground plate. The carrier gas was nitrogen, purity (99.999%). The default flow rates for the enclosed spray source gas, auxiliary gas 1 and auxiliary ga...

Embodiment 2

[0046] The design of the tandem differential ion mobility-mass spectrometry device is as follows: figure 2 As shown, the channel size of the series differential migration spectrum is 40mm×20mm×1.4mm (length×width×channel width), the material of the migration outer cavity is polyether ether ketone, the electrode material is C316 stainless steel, and the width of the two-stage interface is 5mm. Among them, 1-nano-electrospray ion source sampling device; 2-closed ion source cavity; 3-ion source auxiliary gas interface I; 4-gas cylinder; 5-first-stage dopant addition device; 6-second Level dopant adding device; 7-first-level migration outer chamber Ⅰ; 8-first-level migration first electrode plate; 9-two-level interface; 10-second-level migration first electrode plate; 11-second-level migration outer cavity Ⅰ ;12-Mass spectrometer transmission capillary; 13-First-stage auxiliary gas; 14-Second-stage auxiliary gas; 15-Ion source auxiliary gas interface II; 16-Buffer gas outlet; 17-...

Embodiment 3

[0050] In this experiment, PEG was used to evaluate the effects of different ground plate lengths and differential ion migration plates on signal strength, half-peak width, compensation voltage and resolution. The specific results are shown in Table 1-3. As shown in Table 1, for a differential ion transport system with a plate length of 60 mm, separation is difficult to achieve without the addition of dopants, PEG 7 -PEG 12 The signal strength is between 1.42E+08 and 3.17E+09, and the compensation voltage is between -3.21 and -1.63V. The half-peak width range is between 0.64 and 0.90V, and the resolution is 2.42 to 4.05. After adding n-propanol at a concentration of 0.5% as a dopant, PEG 7 -PEG 12 The signal strength is between 1.13E+07 and 3.09E+08, and the compensation voltage is between -1.18 and 17.05V. The half-peak width range is between 0.61 and 0.96V, and the resolution is 0.26 to 26.24. for PEG 7-9 The resolution is significantly improved. After further increas...

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Abstract

The invention relates to a differential ion mobility spectrometry-mass spectrometry combined device based on series connection of grounding electrode plates and application, which belong to the fieldof analytical testing. The differential ion mobility spectrometry-mass spectrometry combined device comprises a sample injection system, a differential ion mobility spectrometry system and a mass spectrometer, wherein the differential ion mobility spectrometry system comprises a first electrode plate and a second electrode plate, and the front end of the first electrode plate or the second electrode plate is connected with the grounding electrode plate in an insulating manner. By adopting the front grounding electrode plate, the gas jet flow can be reduced, the speed dispersion effect can be reduced, and the differential ion migration-mass spectrometry combined overall performance can be improved under the condition that a doping agent is used.

Description

technical field [0001] The invention belongs to the field of analysis and detection, and in particular relates to a differential ion mobility spectrometry-mass spectrometry device and an application thereof for improving the performance of grounded plates connected in series. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Ion mobility spectrometry is a detection technique based on rapid separation in the gas phase. In principle, the qualitative and quantitative analysis of target substances is achieved by measuring the mobility of gas phase ions in an electric field. In recent years, ion mobility spectrometry has gained widespread attention and application in the fields...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04H01J49/16H01J49/00G01N27/62
CPCH01J49/04H01J49/165H01J49/0072G01N27/622Y02A20/20
Inventor 陈相峰吴日汪泽陈德华
Owner SHANDONG ANALYSIS & TEST CENT
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