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Long-acting membrane oxygenator hollow fiber anticoagulant coating for extracorporeal membrane oxygenation (ecmo) and preparation method

A membrane oxygenator and oxygenation technology, applied in the field of new medical materials, can solve the problems of complex process, blocking, easy to coat holes of uneven hollow fibers, etc.

Active Publication Date: 2021-03-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a long-acting membrane oxygenator hollow fiber anticoagulant coating for extracorporeal membrane oxygenation (ECMO) and a preparation method thereof. Block polymers, blended with PMP polymers and diluents to obtain high-temperature melts, and use "thermally induced phase separation" to prepare hollow fibers covered with a layer of anti-coagulation coating, which solves the problem of anti-coagulation coating of PMP hollow fibers The complexity of the layer process, and the existing formula liquid coating method is easy to coat unevenly or block the holes of the hollow fiber

Method used

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  • Long-acting membrane oxygenator hollow fiber anticoagulant coating for extracorporeal membrane oxygenation (ecmo) and preparation method
  • Long-acting membrane oxygenator hollow fiber anticoagulant coating for extracorporeal membrane oxygenation (ecmo) and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Synthetic Macromolecular Additives 1

[0028] Add 0.2 parts by mass of methacryloxyethyl phosphorylcholine, 0.3 parts by mass of butyl methacrylate, 0.36 parts by mass of 4-methylpentene, 0.15 parts by mass of methacrylic acid hydroxyl Isopropyl, 0.05 parts by mass of methacryloxypropyltrimethoxysilane, 0.005 parts by mass of dimethyl azobisisobutyrate and 4 parts by mass of isopropanol, stirred evenly and passed into nitrogen protection , after 12 hours of reaction at 60°C. A large amount of acetone was added to precipitate the polymer, and finally the macromolecular additive 1 was obtained by vacuum drying at room temperature.

Embodiment 2

[0030] Synthetic Macromolecular Additives 2

[0031] Add 0.2 parts by mass of methacryloyl ethyl sulfobetaine, 0.4 parts by mass of lauryl methacrylate, 0.2 parts by mass of ethyl methacrylate, 0.15 parts by mass of isocyanate ethyl methacrylate Esters, 0.005 parts by mass of dimethyl azobisisobutyrate and 4 parts by mass of methyl lactate were uniformly stirred and then passed into nitrogen protection, and reacted at 60° C. for 6 hours. A large amount of acetone was added to precipitate the polymer, and finally the macromolecular additive 2 was obtained by vacuum drying at room temperature.

Embodiment 3

[0033] Synthetic Macromolecular Additives 3

[0034] Add 0.4 parts by mass of methacryloxyethyl phosphorylcholine, 0.65 parts by mass of methyl methacrylate, 0.05 parts by mass of glycidyl methacrylate, 0.005 parts by mass of azobis Dimethyl isobutyrate and 4 parts by mass of isopropanol were stirred evenly, and then nitrogen protection was introduced, and reacted at 60° C. for 12 hours. A large amount of acetone was then added to precipitate the polymer, and finally the macromolecular additive 3 was obtained by vacuum drying at room temperature.

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Abstract

The invention discloses a long-acting membrane oxygenator hollow fiber anticoagulation coating for extracorporeal membrane oxygenation (ECMO) and a preparation method. The method comprises the following steps: (1) mixing PMP, a diluent and a macromolecular additive for coating preparation, heating to 200-300 DEG C in a protective gas atmosphere, stirring for 4-8 hours to form a homogeneous solution, and carrying out vacuum degassing; and (2) extruding the product obtained in the step (1) by an extruder, preparing hollow fibers while passing through a coagulating bath, extracting, and curing at30-60 DEG C. The coating macromolecular additive used in the invention is a triblock polymer obtained by free radical polymerization; then the triblock polymer is blended with a PMP polymer and a diluents, and the mixture is melted to obtain a high-temperature melt, then a thermally induced phase separation method is adopted to prepare hollow fiber evenly covered with a layer of coating with highstability on the surface, and the coating has long-acting anticoagulation performance.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, and in particular relates to a hollow fiber anticoagulation coating for a long-acting membrane oxygenator used in extracorporeal membrane oxygenation (ECMO) and a preparation method thereof. Background technique [0002] Membrane oxygenator is a clinically essential medical device, mainly used to oxygenate blood, such as ECMO equipment. The key to the membrane oxygenator is the internal hollow fiber. The wall of this fiber has a connected pore structure. Due to the extremely small pore size and hydrophobicity, the blood is not easy to permeate and the gas can pass through, thereby achieving oxygenation. At present, most of the hollow fibers made of PMP are used clinically, which are prepared by the method of "thermally induced phase separation". solution, and then pass through a spinneret to obtain hollow fiber, then pass through a coagulation bath and quenching to solidify and sha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/06A61L33/04A61L33/00A61M1/18
CPCA61L33/0005A61L33/0011A61L33/04A61L33/064A61L2300/214A61L2300/216A61L2300/42A61L2400/18A61L2420/02A61L2420/06A61M1/16C08L23/20
Inventor 王云兵张凡军罗日方杨立张兴栋
Owner SICHUAN UNIV
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