Long-acting membrane oxygenator hollow fiber anticoagulant coating for extracorporeal membrane oxygenation (ecmo) and preparation method

Abstract

The invention discloses a long-acting membrane oxygenator hollow fiber anticoagulation coating for extracorporeal membrane oxygenation (ECMO) and a preparation method. The method comprises the following steps: (1) mixing PMP, a diluent and a macromolecular additive for coating preparation, heating to 200-300 DEG C in a protective gas atmosphere, stirring for 4-8 hours to form a homogeneous solution, and carrying out vacuum degassing; and (2) extruding the product obtained in the step (1) by an extruder, preparing hollow fibers while passing through a coagulating bath, extracting, and curing at30-60 DEG C. The coating macromolecular additive used in the invention is a triblock polymer obtained by free radical polymerization; then the triblock polymer is blended with a PMP polymer and a diluents, and the mixture is melted to obtain a high-temperature melt, then a thermally induced phase separation method is adopted to prepare hollow fiber evenly covered with a layer of coating with highstability on the surface, and the coating has long-acting anticoagulation performance.

Description

technical field

[0001] The invention belongs to the technical field of new medical materials, and in particular relates to a hollow fiber anticoagulation coating for a long-acting membrane oxygenator used in extracorporeal membrane oxygenation (ECMO) and a preparation method thereof. Background technique

[0002] Membrane oxygenator is a clinically essential medical device, mainly used to oxygenate blood, such as ECMO equipment. The key to the membrane oxygenator is the internal hollow fiber. The wall of this fiber has a connected pore structure. Due to the extremely small pore size and hydrophobicity, the blood is not easy to permeate and the gas can pass through, thereby achieving oxygenation. At present, most of the hollow fibers made of PMP are used clinically, which are prepared by the method of "thermally induced phase separation". solution, and then pass through a spinneret to obtain hollow fiber, then pass through a coagulation bath and quenching to solidify and sha...

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