Passive micro-mixer for chemiluminescence detection and use method of passive micro-mixer
A chemiluminescence detection and micro-mixer technology is applied in the fields of microfluidic technology and biochemical detection, which can solve the problems such as the inability to achieve the strongest luminescence intensity, the complex structure of the microfluidic chip, and the increase of the length of the detection channel, so as to speed up the chemical reaction. speed, shorten the mixing distance, and improve the effect of detection sensitivity
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[0039] Example 1:
[0040] A cross-type passive micromixer for chemiluminescence detection, such as figure 1 As shown, it includes a micro-mixer base 1 and a cross-shaped channel arranged in it. The four directions of the cross-shaped channel are: the sample channel to be tested 4, the first sheath flow channel 6-1, the detection channel 10, and the second The sheath flow channel 6-2, the sample channel to be tested 4, the first sheath flow channel 6-1, the outflow end of the second sheath flow channel 6-2 and the inlet end of the detection channel 10 are connected through the mixing chamber 2, and the mixing chamber 2 is connected to the detection channel 10 through a narrow connecting channel 9, the outflow end of the detection channel 10 is connected to the waste liquid pool 8 through the waste liquid outflow channel 7, and the inflow end of the sample channel 4 to be tested is connected to the sample liquid reservoir to be tested 3 connection, the inlet ends of the first shea...
Example Embodiment
[0046] Example 2:
[0047] A Y-type passive micro-mixer for chemiluminescence detection, comprising a micro-mixer base 1 and a Y-type channel arranged inside it, such as Figure 5 As shown, the three directions of the Y-shaped channel are: sample channel to be tested 4, sheath flow channel 6, detection channel 10, sample channel to be tested 4, the outflow end of sheath flow channel 6 and the inflow end of detection channel 10 The mixing chamber 2 is connected, the mixing chamber 2 and the detection channel 10 are connected through a narrow connection channel 9, the outflow end of the detection channel 10 is connected to the waste liquid pool 8 through the waste liquid outflow channel 7, and the inflow of the sample channel 4 to be tested The end is connected to the sample reservoir 3 to be tested, and the inlet end of the sheath flow channel 6 is connected to the sheath flow reservoir 5.
[0048] The detection channel 10 is composed of more than 3 mixing units (101, 102, 103, 104...
Example Embodiment
[0052] Example 3:
[0053] A method for using the cross-type passive micro-mixer of Embodiment 1 to perform chemiluminescence detection of the transition metal cobalt ion concentration using the cross-type passive micro-mixer of Embodiment 1 includes the following steps:
[0054] (1) To clean the flow path, use 1.0mol L in turn -1 Wash with NaOH for 30 minutes, then wash with ultrapure water for 5 minutes;
[0055] (2) The sample storage tank 3, the first sheath flow storage tank 5-1, and the second sheath flow storage tank 5-2 are respectively used to hold the cobalt chloride solution, hydrogen peroxide solution and Lu Minoan solution;
[0056] Negative pressure is applied to the waste liquid tank 8, or positive pressure is applied to the sample reservoir 3, the first sheath flow reservoir 5-1, and the second sheath flow reservoir 5-2 to drive the cobalt chloride solution , The hydrogen peroxide solution and the luminol solution move to the detection channel 10. The above solution c...
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