A magnetic resonance device for real-time monitoring of the temperature of the lesion area

A technology for real-time monitoring and lesion area, which is applied to cooling appliances for therapeutic treatment, heating appliances for therapeutic treatment, image analysis, etc. Trauma, high-resolution effects

Active Publication Date: 2022-04-19
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

However, the temperature accuracy obtained by MRI temperature measurement is ±1°C. When the commonly used PRF (proton nuclear magnetic resonance frequency) phase subtraction method is used for in vivo real-time temperature measurement, it is easily affected by fat signals, motion artifacts, and phase winding. MR-ARFI-based method for the quantitative measurement of tissue elasticity: application for monitoring HIFU therapy[J]. Physics in Medicine & Biology , 2018, 63(9):095018)

Method used

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  • A magnetic resonance device for real-time monitoring of the temperature of the lesion area
  • A magnetic resonance device for real-time monitoring of the temperature of the lesion area

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Embodiment 1

[0032] Such as figure 1 As shown, a magnetic resonance device for real-time monitoring of the temperature of the lesion area, including

[0033] Positioning image module: Send the lesion area into the center of the MRI magnet, use the positioning image sequence to obtain low-resolution positioning images of the lesion area, and determine the field of view (FOV) of T2WI images and temperature imaging based on the positioning images;

[0034] Preferably, the gradient echo family sequence is used to obtain the positioning image, for example, the FLASH sequence is used to quickly collect data to obtain a low-resolution positioning image.

[0035] T2WI image module: Based on the FOV, use T2WI sequence to obtain T2WI images of high-resolution anatomical structures of the lesion area and surrounding normal tissues and analyze them statistically;

[0036]Preferably, T2WI images are acquired using spin echo-echo planar imaging (SE-EPI) sequence to speed up data acquisition and ensure ...

Embodiment 2

[0043] In this embodiment, a GE 3.0T MR imager is used to guide patients with bladder cancer in real time to receive pirarubicin hydrochloride hyperthermic perfusion chemotherapy. Routine clinical 1.5T and 3.0T MR imagers are available, such as uMR 3.0T MR imager, GE 3.0T MR imager, Philips Achieva 1.5T MR imager, etc.

[0044] A magnetic resonance device for real-time monitoring of the temperature of the lesion described in Example 1 is applied to real-time guidance of hyperthermic perfusion chemotherapy for bladder cancer, such as figure 2 As shown, the specific steps are as follows:

[0045] Step 1: Prepare, check, and connect relevant perfusion chemotherapy equipment according to the routine process of hyperthermic perfusion chemotherapy, connect the one-time-use body cavity hyperthermic perfusion therapy pipeline components, and preheat the equipment. Prepare perfusion fluid, patient-related preparation, no need to insert temperature sensor in patient perfusion area;

...

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Abstract

The present invention proposes a device for magnetic resonance real-time monitoring of the temperature of the lesion area, including a positioning image module, a T2WI image module, a temperature image module and a warning module, and the temperature average value of the ROI of the MRI temperature distribution map and the signal average value of the T2WI image are used as Judging criteria, to avoid single temperature imaging parameters being easily affected by external factors, resulting in inaccurate calculation of ROI temperature, signal average value, etc., and affecting the effect of temperature monitoring. The device of the present invention evaluates the temperature change in the process of hyperthermic perfusion chemotherapy by the change of the average signal intensity of ROI, and can observe in real time whether hyperthermic perfusion chemotherapy has any effect on normal tissues by comparing the temperature distribution map of the perfusion area and the average value of the ROI of the T2WI image with the initial value. damage.

Description

technical field [0001] The invention relates to the field of magnetic resonance (MRI) application technology, in particular to a device for real-time monitoring of the temperature of a lesion area by magnetic resonance. Background technique [0002] The existing temperature measurement methods for the lesion area are mainly based on the sensors inserted in the lesion area. The range and accuracy of temperature measurement are greatly affected by the number and distribution of temperature sensors, and not all the temperature of the lesion area is obtained, let alone the temperature around the lesion area. Therefore, it is of great significance to accurately and effectively obtain the temperature of the lesion area and its surrounding normal tissues, and use it in hyperthermic perfusion chemotherapy, microwave ablation, ultrasound focusing, and radiofrequency ablation. [0003] Hyperthermic perfusion chemotherapy is a way to treat bladder cancer. A large-capacity perfusion sol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/00G06T7/70A61F7/12A61F7/00
CPCG06T7/0012G06T7/70A61F7/12A61F7/0053A61F2007/0059G06T2207/10088G06T2207/20104
Inventor 孙夕林王洪斌杨春升王凯徐佐宇杨丽丽吴丽娜官小红
Owner HARBIN MEDICAL UNIVERSITY
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