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Implantable biosensor and manufacturing method thereof

A technology of biosensors and manufacturing methods, applied in the field of implantable biosensors and their manufacture, can solve the problems of complex production process, low degree of automation, high sensor price, etc., and achieve the effect of reducing production costs

Pending Publication Date: 2020-11-03
DREISAM (BEIJING) MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The manufacturing process of existing biosensors is a specific process method for a specific detection item. Taking implantable blood glucose monitoring sensors as an example, the current sensors for blood glucose monitoring usually use the first generation of glucose oxidase electrodes. , the production process is generally complicated and the degree of automation is low, resulting in high sensor prices

Method used

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  • Implantable biosensor and manufacturing method thereof
  • Implantable biosensor and manufacturing method thereof
  • Implantable biosensor and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: a kind of implantable biosensor, such as figure 1 As shown, a flexible substrate 1 is included, and in this example, the flexible substrate 1 is a PET film. The flexible substrate 1 includes a first base surface and a second base surface, and the first base surface and the second base surface are provided with an insulating coating 3; the first base surface of the flexible substrate 1 is provided with a first The conductive layer is formed with a working electrode region 8 and a reference electrode region 10, and is also provided with a first conductive strip 4 corresponding to the working electrode region 8 and a second conductive strip 5 corresponding to the reference electrode region 10, and is also provided with The first connection area 7 and the second connection area 9 connected with external electronic equipment, the first base surface is also provided with an insulating coating 3; the second base surface of the flexible substrate 1 is provided wit...

Embodiment 2

[0030] Embodiment 2: A method for manufacturing an implantable biosensor, taking an implantable blood glucose monitoring sensor as an example, includes the following steps:

[0031] Step S01: forming a gold conductive layer on the first base surface and the second base surface of the PET substrate by sputtering;

[0032] Step S02: screen printing an insulating coating on the second base surface of the flexible substrate;

[0033] Step S03: using laser etching to remove part of the gold conductive layer on the first base surface of the flexible substrate to form electrode areas, conductive strips and connection areas with external electronic devices;

[0034] Step S04: Screen printing an insulating coating on the first base surface of the flexible substrate, where the insulating coating is printed on the first base surface except for the electrode area and the connection area with external electronic equipment;

[0035] Step S05: making the working electrode induction layer; s...

Embodiment 3

[0044] Embodiment 3: the manufacturing method of implantable biosensor, comprises the steps:

[0045] Step S01 to step S04 are the same as in Embodiment 2.

[0046] Step S05: making a working electrode induction layer. Specifically, making the working electrode includes the following steps:

[0047]S051: Same as Example 2

[0048] S052: Place the alcoholic aqueous solution containing polymer copolymers on the working electrode area by micro-droplet method, and form polymer spots after drying. The difference from Example 2 is that in this example, as long as the working electrode area is covered by polymer spots.

[0049] S053: Place a photomask above the first base surface, and use the photomask to define the shape and area of ​​the surface that can receive ultraviolet light irradiation in the working electrode region. The polymer spots in this range are cross-linked and fixed on the surface of the working electrode after being irradiated with ultraviolet rays. Polymers n...

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Abstract

The invention discloses an implantable biosensor. The implantable biosensor comprises a flexible substrate, wherein the flexible substrate comprises a first basal surface and a second basal surface, and the first basal surface is provided with two electrode structures, namely a working electrode and a reference electrode. The electrodes are connected with an external electronic equipment connection area through a conductive band. Except the electrode area and the area connected with the external electronic equipment, the first base surface is coated with an insulating coating. The conductive layer of the second base surface forms a connecting area of the electrode area and the external electronic equipment by printing the insulating coating. By applying a chemical process provided by the invention, an enzyme-containing polymer network layer can be simply, conveniently and accurately fixed to the surface of the working electrode to form an induction layer by combining a photoetching technology, and the functionality of the induction layer is guaranteed. The method is low in process complexity, main working procedures can be completed through one-time planarization processing, automatic production is facilitated, and the production cost is greatly reduced.

Description

technical field [0001] The invention relates to the field of biosensors, in particular to an implanted biosensor and a manufacturing method thereof. Background technique [0002] A biosensor is a device and system for obtaining external information. It is a supplement and extension of human sensory functions. It uses biologically active substances as sensitive elements, and its realization mechanism is closer to the sensory system of the organism itself. Substances are quickly analyzed and tracked. Biosensors are mainly composed of two parts: sensitive components that generate signals and auxiliary instruments that process signals. Among them, the sensitive component is the core of the whole biosensor. Sensitive components include two parts: sensitive elements and transducers. Sensitive elements refer to biologically active units that selectively act on targets, such as enzymes, antibodies, DNA, nucleic acids, cell receptors, and intact cells with selective specific funct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/04
CPCA61B2562/12
Inventor 乌宁
Owner DREISAM (BEIJING) MEDICAL TECH CO LTD