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Magnetic control micro-needle robot as well as preparation method, use method and application thereof

A robot and microneedle technology, applied in the field of medicine, can solve the problems of not being able to meet the release requirements of a one-time large dose, not being able to perform skin puncture, and long treatment cycles, so as to avoid the first-pass effect, increase drug loading, and avoid Effects of drug wastage

Pending Publication Date: 2020-11-03
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polymers such as polylactic-co-glycolic acid (PLGA) are used as microneedles, which have widely adjustable mechanical properties and certain biocompatibility, but their hydrophobic properties make it difficult to coat and carry hydrophilic drugs.
Hydrogel microneedles have the advantages of biocompatibility, biodegradability, low cost, easy modification, and the ability to coat a variety of drugs, but their poor mechanical properties prevent skin puncture
At the same time, the unit drug loading of polymers such as hydrogel or PLGA cannot meet the release requirements of a one-time large dose, the drug utilization rate is low, and the treatment cycle time is long

Method used

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  • Magnetic control micro-needle robot as well as preparation method, use method and application thereof
  • Magnetic control micro-needle robot as well as preparation method, use method and application thereof
  • Magnetic control micro-needle robot as well as preparation method, use method and application thereof

Examples

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Comparison scheme
Effect test

preparation example 1

[0065] A magnetic iron-based metal-organic framework, the preparation method of which is as follows:

[0066] (1) Mix ferric nitrate and (trichloromethyl) carbonate (BTC), and react for 24 hours at 120° C. in a high-pressure reactor. The powder obtained after the solution is dried is washed with methanol for 24 hours, and dried to obtain an organometallic framework MOFs powder;

[0067] (2) The metalorganic framework MOFs powder, Fe3O4 nanoparticles and nickel nanoparticles (mass ratio 19:4:1) were mixed and stirred in methanol for 6 h, and then vacuum-dried at 80 °C to obtain magnetic iron-based metal organic skeleton.

preparation example 2

[0069] A magnetic iron-based metal-organic framework, the preparation method of which is as follows:

[0070] (1) From 1mmol of Fe 3+ (FeCl 3 , Fe(NO 3 ) 3 and Fe 2 (SO 4 ) 3 , the mass ratio is 1:1:1), 1mmol of H 2 BDC-OH in N,N'-dimethylformamide (DMF, 5 mL); the reactants were stirred for 5 min, then the resulting suspension was introduced into a Teflon-lined steel autoclave, and the temperature was set to Set at 150°C for three days; the light orange MIL-53(Fe)[DMF] powder was first washed with MeOH, and finally, after being dispersed in water and dried in air, MIL-53(Fe) was obtained.

[0071] (2) MIL-53(Fe) powder and Fe3O4 nanoparticles (mass ratio: 19:3) were mixed and stirred in methanol for 6 h, and then vacuum-dried at 80 °C to obtain a magnetic iron-based metal-organic framework.

preparation example 3

[0073] A magnetic iron-based metal-organic framework, the preparation method of which is as follows:

[0074] (1) by Fe 2+ (FeCl 2 , Fe(NO 3 ) 2 and Fe 2 (SO 4 ) 2 , mass ratio 1:1:1) (80mg, 0.40mmol) and H 4 DOBDC (40 mg, 0.20 mmol) was dissolved in a solution of N,N-dimethylformamide (3.7 mL), a mixture of 2-propanol (0.2 mL) and water (0.2 mL); sealed in a capped vial, And place it in a heating oven at 105°C for 24 hours to obtain dark brown needle-like crystals; after filtering, rinse the crystals thoroughly with methanol, and then dry them in air; the methanol-exchanged sample obtained after soaking once was placed in methanol for 24 hours , and then heated at 200 °C for 6 h under vacuum to obtain the Fe-based MOF.

[0075] (2) Fe-based metal-organic framework powder and nickel nanoparticles (mass ratio: 19:1) were mixed and stirred in methanol for 6 h, and then vacuum-dried at 80° C. to obtain a magnetic iron-based metal-organic framework.

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Abstract

The invention provides a magnetic control micro-needle robot and a preparation method, use method and application thereof. The magnetic control micro-needle robot comprises a micro-needle structure, and the micro-needle structure comprises a micro-needle body and a magnetic layer located on the outer side of the needle tip of the micro-needle body; and the composition component of the magnetic layer comprises a magnetic metal organic framework. The magnetic control micro-needle robot provided by the invention has relatively high mechanical strength and can realize transdermal drug delivery; besides, the magnetic layer with the organic metal framework is separated from the micro-needle body and is reserved in the body, and long-time attachment is not needed; and active ingredients are adsorbed in the organic metal framework, so that targeted therapy on positions such as tumors can be realized. The magnetic control micro-needle robot provided by the invention can realize targeted therapy, has a relatively high utilization rate of active ingredients, and can ensure targeted long-acting release of the active ingredients in bodies.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a magnetically controlled microneedle robot and its preparation method, use method and application, in particular to a magnetically controlled microneedle robot for targeted treatment of tumors and its preparation method, use method and application. Background technique [0002] New cancer cases are increasing every year, so it is necessary to vigorously develop or improve cancer treatment drugs. Malignant lesions of important organs of the human body need to be surgically removed when they become malignant tumors; however, small tumors cannot be completely removed because they hide in the corners of the organs or are in very dangerous positions. One of the important causes of cancer recurrence. [0003] The size of the micro-nano robot is equivalent to that of microorganisms, and it has the potential to enter the human body to implement targeted therapy, and can realize minimall...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/00A61K47/36A61K47/10A61K47/34A61K47/02
CPCA61M37/0069A61M37/0015A61K9/0021A61K47/36A61K47/10A61K47/34A61K47/02A61M2037/0046A61M2037/0061A61M2037/0053A61M2205/0272A61M2205/0277
Inventor 郑裕基陈志穆学良林丽李泽顺
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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