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A kind of hollow gastric floating tablet of low-solubility drug prepared based on semi-solid 3D printing technology and preparation method thereof

A 3D printing and gastric floating tablet technology, which is applied in drug delivery, pharmaceutical formulations, antibacterial drugs, etc., can solve the problems of long drug release time and incomplete drug release, so as to prolong the residence time, reduce the number of drugs taken, and improve The effect of treatment compliance

Active Publication Date: 2022-07-05
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The simple use of water-insoluble materials or the combination of water-insoluble materials and water-insoluble materials can easily lead to incomplete drug release or long drug release time

Method used

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  • A kind of hollow gastric floating tablet of low-solubility drug prepared based on semi-solid 3D printing technology and preparation method thereof
  • A kind of hollow gastric floating tablet of low-solubility drug prepared based on semi-solid 3D printing technology and preparation method thereof
  • A kind of hollow gastric floating tablet of low-solubility drug prepared based on semi-solid 3D printing technology and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A preparation method of a hollow clarithromycin gastric floating tablet prepared based on a semi-solid 3D printing technology: the raw and auxiliary materials are respectively passed through a 90-mesh sieve;

[0065] 1: Take the release modifier (Poloxamer P407 0.10g), the binder (Povidone K30 0.70g), and the water-erodible polymer skeleton material (Hypromellose (K100 MCR) 0.90g), mix Evenly, add 15 mL of 95% ethanol, stir evenly, clarithromycin micropowder 5.4 g, and stir until solidified. Crush the solidified product, slowly add 3.0 mL of water and stir evenly to obtain a clarithromycin drug-containing layer paste, which is loaded into the 3D printing barrel A for use.

[0066] 2: Take 4.2 g of water-insoluble polymer material-ethyl cellulose (EC 20), add it to 50 mL of absolute ethanol, stir until dissolved, then add inorganic carbonate (0.40 g of sodium bicarbonate powder), stir at high speed to disperse evenly. 1.40 g of sodium carboxymethyl cellulose, a water-e...

Embodiment 2

[0071] A preparation method of a hollow clarithromycin gastric floating tablet prepared based on a semi-solid 3D printing technology: the raw and auxiliary materials are respectively passed through a 90-mesh sieve.

[0072] 1: Take release modifier (PEG 4000 0.60g), binder (crospovidone 0.30g), water-erodible polymer skeleton material (carbomer 934p 0.70g), mix well, add 11mL of 95% ethanol, Stir well, and stir 6.80 g of clarithromycin micropowder until it solidifies. Crush the solidified product, slowly add 2.5 mL of water and stir evenly to obtain a clarithromycin drug-containing layer paste, which is loaded into the 3D printing barrel A for use.

[0073] 2: Take 2.0g of water-insoluble polymer skeleton material - Eudragit E PO, add it to 30mL of absolute ethanol, stir until dissolved, add inorganic carbonate (sodium bicarbonate powder 0.55g), stir at high speed to disperse evenly. Add 1.20 g of water-erodible polymer material-Carbomer 934p powder, and stir at high speed to...

Embodiment 3

[0078] A preparation method of a hollow clarithromycin gastric floating tablet prepared based on a semi-solid 3D printing technology: the raw and auxiliary materials are respectively passed through a 120-mesh sieve.

[0079]1: Take the release modifier (poloxamer P188 0.50g), the binder (hypromellose k30 0.40g), the water-erodible polymer skeleton material (chitosan 0.50g), mix well, add 95% ethanol 13mL, stir well, clarithromycin micropowder 7.2g, stir until solidified. Crush the solidified product, slowly add 3.5 mL of water and stir evenly to obtain a clarithromycin drug-containing layer paste, which is loaded into the 3D printing barrel A for use.

[0080] 2: Water-insoluble polymer skeleton material-ethyl cellulose (EC 100) 3.40g, add 60mL absolute ethanol, stir until dissolved, add inorganic carbonate (sodium bicarbonate powder 0.45g), stir at high speed to disperse evenly. 2.20 g of water-erodible polymer skeleton material-gelatin was added, and a suspension gel was f...

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Abstract

The invention discloses a low-solubility drug hollow gastric floating tablet and a preparation method thereof. The tablet structure includes an outer drug-containing layer and a tablet core filling layer. The outer drug-containing layer includes a water-erodible polymer skeleton material, a release regulator, an adhesive, and clarithromycin; the core filling layer includes a composite polymer material and an inorganic carbonate, and has a hollow structure after drying , which is mainly used to provide higher floating capacity for the middle and final stages of tablet release and stabilize its retention effect in the stomach. The invention realizes the combination of high drug loading, continuous floating and hollow structure, and verifies the possibility of semi-solid 3D printing technology in preparing a local precise drug delivery system with special structure. The hollow clarithromycin gastric floating tablet prepared based on the semi-solid 3D printing technology provided by the invention has the functions of gastric retention and sustained release, and can enhance the efficacy of clarithromycin in the treatment of Helicobacter pylori by combined medication.

Description

technical field [0001] The invention relates to a gastric floating drug delivery system, in particular to a hollow gastric floating tablet of low-solubility drugs prepared based on semi-solid 3D printing technology. At the same time, the invention also relates to a preparation method of the gastric floating sustained-release tablet. Background technique [0002] 3D printing technology has the advantages of precise dosage and personalized customization, and has received more and more attention in the field of drug preparation development in recent years. Compared with the currently widely studied hot melt extrusion 3D printing technology, semi-solid 3D printing technology has the characteristics of mild conditions and high drug loading, which avoids the use of high temperature and reduces the risk of degradation of raw materials, especially for temperature-sensitive materials. Drugs and Excipients. However, the current research on semi-solid 3D printing technology is mostly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K47/10A61K47/32A61K47/38A61K47/36A61K31/7048A61P31/04B33Y80/00B33Y10/00
CPCA61K9/0065A61K9/2031A61K9/2027A61K9/2054A61K9/205A61K31/7048A61P31/04B33Y80/00B33Y10/00
Inventor 陈燕忠吕竹芬陈培鸿
Owner GUANGDONG PHARMA UNIV
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