Coated artificial bone and preparation method thereof
An artificial bone and coating technology, applied in the medical field, can solve the problems of mismatching degradation speed and single artificial bone structure, and achieve the effect of simple preparation method, easy promotion and implementation
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Embodiment example 1
[0047] (1) Preparation of binder: 8g of polyvinyl alcohol and 92g of sterile water for injection and 10g of polyvinyl alcohol and 90g of sterile water for injection were respectively prepared into 8% and 10% polyvinyl alcohol aqueous solutions by mass fraction, placed in The jar with lid was heated and swollen in a water bath at 60°C for 2h, and then stirred at 250r / min for 2h in a 96°C magnetic stirrer to completely dissolve to form a homogeneous solution;
[0048] (2) Preparation of printing paste: Mix calcium silicate powder with 8% polyvinyl alcohol solution by mass at a mass ratio of 1:1, place it in a vacuum mixer and stir at a speed of 2000r / min for 4 times. For 1 min, then put it into the barrel, and defoamed twice in a homogenizer at a speed of 3000r / min, 2.5mim each time, to form a uniform printing paste.
[0049] (3) 3D model of artificial bone: Obtain CT / MRI / X-rays of the patient’s bone defect, process the data with the software 3D Slicer 4.10.2, and obtain the pro...
Embodiment example 2
[0058] (1) Preparation of binder: 8g of polyvinyl alcohol and 92g of sterile water for injection and 10g of polyvinyl alcohol and 90g of sterile water for injection were respectively prepared into 8% and 10% polyvinyl alcohol aqueous solutions by mass fraction, placed in The jar with a lid was heated and swollen in a water bath at 60°C for 3h, and then stirred at a speed of 300r / min in a 96°C magnetic stirrer for 3h to completely dissolve to form a homogeneous solution;
[0059] (2) Preparation of printing paste: Mix the hydroxyapatite powder with 8% polyvinyl alcohol solution by mass at a mass ratio of 1.12:1, and place it in a vacuum mixer to stir 6 times at a speed of 2000 r / min. Each time for 1min, it is then put into the barrel, and degassed in a homogenizer at a speed of 3000r / min for 3 times, 5mim each time, to form a uniform printing paste.
[0060] (3) 3D model of artificial bone: Obtain CT / MRI / X-rays of the patient’s bone defect, process the data with the software 3D...
Embodiment example 3
[0069] (1) Preparation of binder: 8g of polyvinyl alcohol and 92g of sterile water for injection and 10g of polyvinyl alcohol and 90g of sterile water for injection were respectively prepared into 8% and 10% polyvinyl alcohol aqueous solutions by mass fraction, placed in The jar with a lid was heated and swollen in a water bath at 60°C for 3h, and then stirred at a speed of 300r / min in a 96°C magnetic stirrer for 3h to completely dissolve to form a homogeneous solution;
[0070] (2) Preparation of printing paste: Mix tricalcium phosphate powder with 8% polyvinyl alcohol solution in a mass ratio of 1.4:1, place it in a vacuum mixer and stir at a speed of 2000r / min for 5 times. For 1 min, then put it into the barrel, and defoamed in a homogenizer at a speed of 3000 r / min for 4 times, 5 mim each time, to form a uniform printing paste.
[0071] (3) 3D model of artificial bone: Obtain CT / MRI / X-rays of the patient’s bone defect, process the data with the software 3D Slicer 4.10.2, a...
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