Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition for preventing reduction of abundance of Akkermansia muciniphila in intestinal tract

A composition and intestinal technology, applied in the field of general health and regulation of intestinal microorganisms, can solve problems such as poor specificity, obesity and other diseases, and achieve the effects of preventing abundance reduction, facilitating promotion and high safety.

Active Publication Date: 2020-11-17
广东弘元普康医疗科技有限公司
View PDF10 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the method of regulating the abundance of intestinal Akkermansia muciniphila through prebiotics has poor specificity and may cause defects such as obesity and other diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for preventing reduction of abundance of Akkermansia muciniphila in intestinal tract
  • Composition for preventing reduction of abundance of Akkermansia muciniphila in intestinal tract
  • Composition for preventing reduction of abundance of Akkermansia muciniphila in intestinal tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Fifteen male 8-week-old c57 mice (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were selected for the experiment and divided into 3 groups with 5 mice in each group. Group A was the control group and fed with common food (Chow). Purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., the formula is shown in Table 1; Group B is a high-fat diet feeding model group (HFD), using high-fat feed containing 60kcal% (purchased from Research Diets, item number D12492), Research Diets D12492 60kcal% high-fat feed is generally used as a standard feed for studying obesity and metabolic syndrome. C group adopts containing 60kcal% high-fat diet, and gives the L-valine (V0500 Sigma-AldrichL-valine L-Valine reagent grade, purity ≥ 98%) of 1.5g / kg mouse body weight in drinking water every day, The above-mentioned L-valine powder was dissolved in drinking water and fed to mice. After 16 weeks, mouse feces were collected with sterile...

Embodiment approach 1

[0041] Embodiment 1: oral liquid with L-valine as the active ingredient;

[0042] Taking oral liquid as an example, oral liquid is a new dosage form developed on the basis of decoction and injection. It has the advantages of small dose, fast absorption, stable quality, convenient carrying and taking, and easy storage. It contains a variety of active ingredients. Makes a big difference in quality and taste. Without changing the structure and function of the main active ingredients, how to retain the active ingredients to the greatest extent and improve the taste is a difficult point in the selection of excipients. Adding excipients in oral liquid can improve taste, clarity, stability and product quality.

[0043] Commonly used excipients for oral liquids include: solvents, fragrances, flavoring agents, clarifiers, preservatives, etc. These excipients can be added at the same time, or one of them can be added. Among them, the solvent must be added, and water can be used. Diffe...

Embodiment approach 2

[0049] Embodiment 2: Tablets with L-valine as the active ingredient;

[0050] Tablet has the advantages of accurate dosage, stable quality, convenient taking, carrying and transportation.

[0051] For tablets, the preparation auxiliary materials include one or more of diluents, binders, lubricants and disintegrants, preferably a combination of diluents, binders, lubricants and disintegrants.

[0052] For tablets, preferably, the diluent is one or more of cellulose and inorganic salts. Such as microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, pharmaceutical calcium carbonate, mannitol, etc., to increase the volume of raw materials to help shape them.

[0053] For tablets, preferably, the binder is one of water, ethanol, sodium carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, gelatin and polyvinylpyrrolidone, etc. or more.

[0054] For tablets, preferably, the lubricant is one or more of magnesium stearate, micronized sil...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a composition for regulating the abundance of Akkermansia muciniphila in the intestinal tract. The composition is composed of L-valine and preparation auxiliary materials. Theeffect of preventing the reduction of the abundance of the Akkermansia muciniphila in the intestinal tract is achieved by supplementing a certain amount of L-valine to the intestinal tract. Generally, the content of the Akkermansia muciniphila in the body of a patient suffering from inflammatory bowel disease and obesity can be reduced, and the composition can restore the abundance of the Akkermansia muciniphila in the mode of supplementing the L-valine, so that the metabolic state is improved. The composition can serve as food or a health care product or a medicine for restoring the abundance of the Akkermansia muciniphila.

Description

technical field [0001] The present invention relates to the field of general health, in particular to the fields of food, health products and medicines under the field of general health, especially the technical field of regulating intestinal microorganisms, in particular to a method for regulating the abundance of Akkermansia muciniphila in the intestinal tract Compositions. Background technique [0002] Human gut microbes play an important role in the link between health and disease. Microbiota dysbiosis is associated with various metabolic disorders. Akkermansia muciniphila is a Gram-negative anaerobic coccus. In 2004, Professor Derrien and her team isolated it in the human intestine and named it Akkermansia muciniphila[DerrienM.Akkermansia muciniphila gen.nov.sp.nov.a human intestinal mucin-degradingbacterium.Int.J.Syst.Evol . Microbiol. 2004, 54]. [0003] Low levels of Akkermansia muciniphila in the gut may lead to thinning of the mucosal layer, which leads to a we...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A23L33/175A61K31/198A61K9/08A61K9/20A61K9/16A61K9/48A61K9/14A61P1/00A61P29/00A61P3/04
CPCA23L33/175A61K31/198A61K9/0095A61K9/20A61K9/16A61K9/48A61K9/14A61P1/00A61P29/00A61P3/04A23V2002/00A23V2250/0654A23V2200/32A23V2200/332Y02A50/30
Inventor 王意朱文桢
Owner 广东弘元普康医疗科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com