Polyvinyl alcohol-pectin embolism microsphere, drug-loaded embolism microsphere and preparation method

A technology of polyvinyl alcohol and polyvinyl alcohol solution, which is applied in the field of biomedicine and polymer materials, and can solve the problems of low drug loading of polyvinyl alcohol embolization microspheres, non-degradation of polyvinyl alcohol embolization microspheres, and dependence on sustained release of drugs, etc. problem, to achieve good antibacterial coagulation function, high drug loading capacity, and reduce the effect of residual amount

Pending Publication Date: 2020-11-17
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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Problems solved by technology

[0004] Traditional TACE commonly uses lipiodol-chemotherapy mixed emulsion for embolization, but there are several major defects: ① lipiodol emulsion will have local deposition, and as time goes on, the cytotoxic effect of the drug on the tumor will also decrease; ② although the emulsion is more traditional Chemotherapy reduces systemic adverse reactions, but some drugs still enter the circulatory system, increasing adverse reactions; ③In tumor treatment, the therapeutic effect requires maintaining a certain drug concent

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  • Polyvinyl alcohol-pectin embolism microsphere, drug-loaded embolism microsphere and preparation method
  • Polyvinyl alcohol-pectin embolism microsphere, drug-loaded embolism microsphere and preparation method
  • Polyvinyl alcohol-pectin embolism microsphere, drug-loaded embolism microsphere and preparation method

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Example Embodiment

[0035] A preparation method of polyvinyl alcohol-pectin embolic microspheres comprises the following steps:

[0036] (1) dissolving polyvinyl alcohol in water to prepare polyvinyl alcohol solution with mass concentration of 1-20%; Dissolving pectin in water to prepare pectin solution with mass concentration of 1-10%; Then evenly mixing the polyvinyl alcohol solution and the pectin solution to obtain a polyvinyl alcohol-pectin mixed solution for later use;

[0037] (2) dissolving the emulsifier in the continuous phase, and uniformly mixing to obtain an oil phase for later use; The emulsifier is one or two of Span 80 or tween 80, and the continuous phase is one or two of liquid paraffin, petroleum ether and vegetable oil;

[0038] (3) adding the polyvinyl alcohol-pectin mixed solution obtained in step (1) into the oil phase obtained in step (2), stirring at a rate of 300-5,000 r / min, and uniformly stirring to obtain polyvinyl alcohol-pectin emulsion;

[0039] (4) dissolving glutaral...

Example Embodiment

[0056] Example 1

[0057](1) preparation of polyvinyl alcohol-pectin mixed solution: take 10 mL of 10% polyvinyl alcohol solution and 10 mL of 10% pectin solution, stir them evenly at a stirring rate of 500 r / min for 8 h, and stand still to remove bubbles, so as to obtain polyvinyl alcohol-pectin mixed solution with certain viscosity;

[0058] (2) Emulsification and cross-linking: measure 0.5 mL emulsifier Span-80, dissolve it in 50 mL continuous phase liquid paraffin, and stir it evenly to obtain oil phase, with the rotation speed of 1000 r / min and the stirring time of 20min; Under the stirring condition, the mixed solution of polyvinyl alcohol and pectin was dripped into the oil phase, and the stirring speed was 1000 r / min and the stirring time was 30 min, so that it was dispersed evenly, and the polyvinyl alcohol-pectin emulsion was obtained. Then, 2 mL glutaraldehyde and 1 mL hydrochloric acid are dissolved in 5 mL diethyl ether to obtain a cross-linking agent solution, and th...

Example Embodiment

[0067] Example 2

[0068] (1) preparation of polyvinyl alcohol-pectin mixed solution: take 5 mL of 12% polyvinyl alcohol solution and 15 mL of 10% pectin solution, stir them evenly at a stirring rate of 800 r / min for 8 h, and stand still to remove bubbles, so as to obtain polyvinyl alcohol-pectin mixed solution with certain viscosity;

[0069] (2) Emulsification and crosslinking: 0.5 mL emulsifier Span-80 is weighed and dissolved in 80 mL liquid paraffin, and the oil phase is obtained by stirring uniformly, with the rotating speed of 800 r / min and the stirring time of 30min; Under the stirring condition, the mixed solution of polyvinyl alcohol-pectin was dripped into the oil phase, and the stirring speed was 1500 r / min, and the stirring time was 30 min, so that it was dispersed evenly, and the polyvinyl alcohol-pectin emulsion was obtained. Then, 2.4 mL glutaraldehyde and 1.2 mL hydrochloric acid are dissolved in 6 mL diethyl ether to obtain a cross-linking agent solution, and the...

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Abstract

The invention discloses a polyvinyl alcohol-pectin embolism microsphere, a drug-loaded embolism microsphere and a preparation method. A preparation method of the embolism microsphere comprises the following steps: blending a polyvinyl alcohol solution and a pectin solution to obtain a water phase; dissolving an emulsifier in a continuous phase, and performing uniform mixing to obtain an oil phase;adding the water phase into the oil phase, and performing uniform stirring to obtain polyvinyl alcohol-pectin emulsion; dissolving a cross-linking agent namely glutaraldehyde and a catalyst namely hydrochloric acid in diethyl ether to obtain a mixture, dropwise adding the mixture into the polyvinyl alcohol-pectin emulsion, and performing a cross-linking reaction to obtain a polyvinyl alcohol-pectin suspension; and centrifuging and washing the polyvinyl alcohol-pectin suspension, and then performing freeze-drying to obtain the polyvinyl alcohol-pectin embolism microsphere. The preparation method comprises the steps of dissolving anti-tumor drug in water to obtain an anti-tumor drug solution, then placing the polyvinyl alcohol-pectin microsphere into the anti-tumor drug solution, performingstirring, and enabling the polyvinyl alcohol-pectin embolism microsphere to adsorb the anti-tumor drug to obtain the polyvinyl alcohol-pectin drug-loaded embolism microsphere. The prepared embolism microsphere has certain degradation capacity and higher drug loading capacity.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and polymer materials, and specifically relates to a polyvinyl alcohol-pectin embolic microsphere, a drug-loaded embolic microsphere and a preparation method. Background technique [0002] In interventional therapy technology, transcatheter vascular embolization (TACE) is a very important treatment method, which mainly injects embolic agents into the supply vessels of diseased target organs through arterial or intravenous catheters, so as to occlude the blood vessels and interrupt the blood vessels. blood supply, and ultimately achieve therapeutic purposes. [0003] When using TACE technology to treat tumors, in addition to blocking blood vessels, chemotherapy drugs will also be injected into the tumor, which can not only block the blood supply of the tumor, make the tumor lack the necessary nutrients, but also strengthen the lethality of the drug on the tumor and reduce the risk of drug loss....

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/06A61L24/08
CPCA61L24/06A61L24/08A61L24/0015A61L24/001A61L24/0042A61L2300/23A61L2300/416A61L2300/602C08L29/04C08L5/06
Inventor 雷建都刘兴勇
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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