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Adhesive hemostatic film for promoting healing and preparation method thereof

A technology of hemostatic film and mixed solution, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of high swelling rate, low mechanical properties, poor adhesion properties, etc., achieve high mechanical strength, reduce the formation of scars, The effect of promoting wound healing

Active Publication Date: 2021-10-19
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hemostatic film has the disadvantages of high swelling rate after absorbing blood, low mechanical properties, and poor adhesion.

Method used

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  • Adhesive hemostatic film for promoting healing and preparation method thereof
  • Adhesive hemostatic film for promoting healing and preparation method thereof
  • Adhesive hemostatic film for promoting healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 2.5% (oxidation degree is 50%, dopamine grafting rate is 7.5%, molecular weight is 1500-2200KDa), 0.6% low molecular weight sodium hyaluronate (30 -60KDa), 0.4% exosomes, 0.3% simethicone, 30% acrylamide, 5% N-hydroxysuccinimide acrylate, 0.015% N, N'-methylenebisacrylamide In purified water, stir at 100-200rpm until completely dissolved, continue stirring for 20min, add 7.5% maleic anhydride and 1.2% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)benzene base]-1-acetone, stir at 100-200rpm until the solution is uniform, pre-polymerize for 30min under a UV lamp with a power of 150W and a wavelength of 365nm, take out the prepolymer, and atomize and spray 1.0% acrylate PEG-N on the surface Hydroxysuccinimide ester (2KDa), 0.4% acrylamide, 3% N-hydroxysuccinimide acrylate and 0.018% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy ) The mixed solution of phenyl]-1-acetone was polymerized for 15 min under a ...

Embodiment 2

[0052] Example 2 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 3.5% (the degree of oxidation is 40%, the grafting rate of dopamine is 5%, and the molecular weight is 1500-2200KDa), 0.8% low molecular weight sodium hyaluronate (10 -50KDa), 0.5% simethicone, 35% acrylamide, 3% N-hydroxysuccinimide acrylate, 0.010% N, N'-methylenebisacrylamide were added to purified water, at 100- Stir at 200rpm until completely dissolved, continue stirring for 20min, add 10% maleic anhydride and 1.4% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone , Stir at 100-200rpm until the solution is uniform, pre-polymerize under a UV lamp for 20 minutes at a power of 150W, a wavelength of 365nm, take out the prepolymer, and atomize and spray 0.5% acrylate PEG-N hydroxysuccinimide ester on the surface (3.4KDa), 0.6% acrylamide, 2% N-hydroxysuccinimide acrylate and 0.028% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]- The mixture of 1-acetone was polymerized for 15 mi...

Embodiment 3

[0053] Example 3 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 1.5% (oxidation degree is 60%, dopamine grafting rate is 10%, molecular weight is 1500-2200KDa), 0.4% low molecular weight sodium hyaluronate (60 -100KDa), 0.2% exosomes, 0.1% simethicone, 25% acrylamide, 7% N-hydroxysuccinimide acrylate, 0.020% N, N'-methylenebisacrylamide In purified water, stir at 100-200rpm until completely dissolved, continue stirring for 20min, add 5% maleic anhydride and 0.9% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)benzene base]-1-acetone, stir at 100-200rpm until the solution is uniform, pre-polymerize for 40min under a UV lamp with a power of 150W, a wavelength of 365nm, take out the prepolymer, and spray 1.5% acrylate PEG-N on the surface Hydroxysuccinimide ester (1KDa), 0.2% acrylamide, 4% N-hydroxysuccinimide acrylate and 0.009% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy ) The mixed solution of phenyl]-1-acetone was polymerized under a UV lamp for 10 min at a powe...

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Abstract

The invention discloses an adhesion-promoting hemostatic membrane and a preparation method thereof. The hemostatic film is composed of high-molecular-weight dopamine-grafted oxidized sodium hyaluronate, low-molecular-weight sodium hyaluronate, exosomes, simethicone, acrylamide, N-hydroxysuccinimide acrylate, N,N'- Methyl bisacrylamide is fully mixed, add maleic anhydride and the first part of photoinitiator, after prepolymerization, add acrylate PEG‑N hydroxysuccinimide ester, dopamine, acrylamide, acrylate N‑hydroxysuccinimide The mixture of the ester and the second part of the photoinitiator is fully polymerized and then vacuum-dried. The hemostatic film can quickly absorb interface moisture, form strong adhesion to tissues through covalent bonds and intermolecular forces, cause mechanical compression to damaged blood vessels, and promote hemostasis. The hemostatic film can also slowly release exosomes and low-molecular-weight sodium hyaluronate, and has a long-term healing-promoting function. Therefore, the hemostatic film has the functions of rapid and efficient hemostasis, adhesion and healing promotion.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an adhesive hemostatic film for promoting healing and a preparation method thereof. The medical hemostatic film of the present application has the functions of fast hemostasis, adhesion, displacement prevention and healing promotion. Background technique [0002] In the first aid of sudden accidents, surgery and in war, 50% of the deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability, and the hemostatic effect is not very satisfactory. Therefore, the development of highly efficient and quickly absorbable hemostatic materials and products, which can effectively stop bleeding within 1-2 minutes or even shorter after the bleeding occurs, has become one of the main goals of the research and development of hemostatic materials. Hemostatic fil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08F285/00C08F220/56C08F220/36C08F290/06C08F222/06C08F222/38C08F2/48
CPCA61L26/0019A61L26/0023A61L26/0057A61L26/0066A61L26/009A61L2400/04C08F2/48C08F285/00C08F290/062C08F220/56C08F220/365C08F222/06C08F222/385
Inventor 张海军袁坤山车超越张淑欣侯文博尹玉霞鲁守涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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