A kit for predicting sperm retrieval outcome in patients with non-obstructive azoospermia

A technology for azoospermia and patients, applied in the field of biomedicine, can solve the problems of poor stability, poor sensitivity, and difficult clinical application of free RNA detection, and achieve fully scientific and practical effects
CN111944895BActive Publication Date: 2022-07-15THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Publication Date
2022-07-15

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Abstract

The invention relates to the field of biomedicine, in particular to a kit for predicting the outcome of sperm extraction for patients with non-obstructive azoospermia. The kit of the present invention includes a reagent for detecting the expression level of lncRNA in the sample, the lncRNA includes SPATA42, CCDC37-DT, GABRG3-AS1, LOC440934, LOC100505685, LOC101929088 (XR_927561.2), LOC101929088 (XR_001745218.1), LINC00343, LINC00343, LINC00343, LINC00343 at least one of them. The invention can realize the non-invasive and accurate prediction of the sperm retrieval outcome of NOA patients before operation, and has sufficient scientificity and practicability.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a kit for predicting the outcome of sperm extraction in patients with non-obstructive azoospermia. Background technique

[0002] Non-obstructive azoospermia (NOA) is one of the most serious male infertility, and its treatment has always been a hot and difficult point in the field of reproductive research at home and abroad. Although sperm cannot be found in the semen, some patients with NOA can still meet their fertility needs by testicular aspiration. However, the existing technology is difficult to predict the outcome of sperm retrieval before surgery, resulting in patients not receiving optimal clinical treatment (screening of patients who are truly suitable for surgery).

[0003] At present, the preoperative markers for predicting the outcome of sperm retrieval in patients with NOA are mainly derived from blood, semen and testicular tissue. Among the above samples, the detection ...

Claims

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