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Photoacoustic/ultrasonic dual-mode high-resolution microscopic imaging system and method

A microscopic imaging, dual-mode technology, applied in the analysis of solids using sound waves/ultrasonic waves/infrasonic waves, material analysis using sound waves/ultrasonic waves/infrasonic waves, and material analysis through optical means, which can solve problems such as low spatial resolution

Inactive Publication Date: 2020-11-17
NANCHANG UNIV
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the problem of low spatial resolution in the photoacoustic ultrasound dual-mode microscopic imaging system in the prior art, and provide a high-resolution photoacoustic ultrasound that can obtain a resolution at the capillary size level. Microscopic imaging system

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  • Photoacoustic/ultrasonic dual-mode high-resolution microscopic imaging system and method

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Embodiment 1

[0029] figure 1 It is a schematic diagram of the principle structure of the whole imaging system of the present invention. The main components of the system include a pulsed laser generator 1, a first condenser lens 2, a single-mode optical fiber 3, a second condenser lens 4, an objective lens 5, a sample 6, a water tank 7, an acousto-optic coupling prism 8, and an ultrasonic transducer 9. It consists of a digital delayer 10, an ultrasonic generator 11, an amplifier 12, an acquisition card 13, a workstation 14, and a three-dimensional scanner 19. The pulse laser generator 1 is used to emit a laser beam with a wavelength of 523 nanometers, a pulse width of 9 nanoseconds, and a repetition rate of 1 KHz. After the laser is emitted, it is coupled into a single-mode optical fiber 3 with a core diameter of 4 microns through the first condenser lens 2 , after being collimated by the second condenser lens 4, it is strongly focused on the sample 6 by the objective lens 5 with a numeri...

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Abstract

The invention discloses a photoacoustic / ultrasonic dual-mode high-resolution microscopic imaging system and method. The system comprises a pulse laser generator, an ultrasonic probe, an ultrasonic generator, a digital delayer, a three-dimensional scanner and an acquisition card; wherein the three-dimensional scanner drives the ultrasonic probe to move in the transverse direction by one step to send out a position synchronization signal, the signal triggers the pulse laser generator to send out a laser pulse, and an opto-acoustic signal is excited through strong focusing of the objective lens;meanwhile, the synchronizing signal is connected into a digital delayer for delaying, an output signal triggers an ultrasonic generator to generate a high-frequency ultrasonic signal, and the high-frequency ultrasonic signal is strongly focused on a sample through an ultrasonic probe, so that a higher transverse resolution ratio is obtained; and finally, the photoacoustic signal and the ultrasonicsignal are amplified and then are sequentially acquired by the acquisition card. According to the invention, based on the photoacoustic / ultrasonic dual-mode high-resolution imaging, the application range of the system is expanded.

Description

technical field [0001] The invention relates to the field of photoacoustic microscopic imaging, in particular to a photoacoustic ultrasonic dual-mode high-resolution microscopic imaging system. Background technique [0002] Photoacoustic imaging is a new imaging technology that has been developed rapidly recently. The principle is to irradiate the sample with a pulsed laser. After the sample is irradiated by the laser, the temperature will rise instantaneously and produce thermoelastic expansion. At this time, the sample will emit ultrasonic waves. After the ultrasonic information is collected by the detector, it can be imaged with a reconstruction algorithm. This method combines the advantages of acoustic and optical imaging at the same time, and has the characteristics of high contrast and high spatial resolution. Photoacoustic imaging has been widely used in various research fields of biomedicine. As an important branch of photoacoustic imaging, photoacoustic microscopy...

Claims

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Application Information

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IPC IPC(8): G01N29/24G01N29/06G01N29/07G01N21/17
CPCG01N21/1702G01N29/0681G01N29/07G01N29/2418G01N2291/0289
Inventor 宋贤林魏剑霜王玉皞周辉林宋玲芳
Owner NANCHANG UNIV
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