The invention provides strong-sealing drilling fluid for preventing collapse of carbonaceous mudstone. The strong-sealing drilling fluid is prepared from water and is further prepared from, by mass of water, 5-15% of liquid phase weighting agent, 3-5% of temperature resisting agent, 3-7% of inhibitor, 0.3-0.5% of tackifier, 2.0-3.0% of fluid loss agent, 4.0-8.0% of blocking agent, 0.1-0.15% of basicity control agent, 1.0-2.0% of lubricant and 30-50% of solid weighting agent. Through the synergistic effect of bridging, filling, deformation, the fluid lock effect and the like, a blocking layer formed on the surface of the well wall is compact in cementation and has a good blocking effect on micro-cracks; the situation that drilling fluid filtrate is immersed into mud rock micro-cracks is effectively reduced, the blocking performance is highlighted, and meanwhile other performance can be considered; liquid phase density is improved, the solid phase content is reduced, and adjustment of the rheological property of the drilling fluid is promoted; reservoir protection is promoted, and the yield of an oil-gas well is increased.