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Florfenicol synthesis method

A florfenicol and compound technology, applied in the field of drug synthesis, can solve problems such as difficulty in recycling, increased energy consumption and safety risks, and serious poisoning in wastewater treatment systems

Inactive Publication Date: 2020-11-24
SHANGHAI VASTPRO TECH DEV CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Fluorinating reagents account for about 15% of the total material cost, and the actual amount used in the process is 1.5 times the theoretical amount of the chemical reaction, while the theoretical utilization rate of fluorine atoms is only one-sixth, resulting in a large amount of fluorine-containing substances becoming waste
Moreover, the Ishikawa reagent (N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine) was converted into the by-product N,N-diethyl-2,3, 3,3-tetrafluoropropionamide and fluoride ions, among them, N,N-diethyl-2,3,3,3-tetrafluoropropionamide is difficult to recycle, and its fluorine-containing wastewater cannot meet the discharge standards. For wastewater The poisoning effect of the processing system is very serious
In addition, due to the stability of the Ishikawa reagent, factory production usually adopts the method of ready-made and ready-to-use. The production process of this reagent requires conditions such as ultra-low temperature, high pressure, and high temperature, which increases energy consumption and safety risks.

Method used

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preparation example Construction

[0061] The invention provides a kind of preparation method of florfenicol, described method comprises steps:

[0062]

[0063] (a) In an inert solvent, in the presence of an organic base, carry out a fluorination reaction with compound I and sulfuryl fluoride, after the fluorination reaction is completed, the reaction mixture is concentrated, and the concentrate is collected without any separation, The purification step is used directly in the next step;

[0064] (b) In an aqueous system, subject the concentrate obtained in the preceding steps to a ring-opening reaction to obtain Florfenicol.

[0065] In another preferred example, in step (a), the ratio of compound I to inert solvent is 1 kg: 5-15 kg or liter; preferably 1 kg: 7-10 kg or liter.

[0066] In another preferred example, in step (a), the inert solvent is selected from the group consisting of acetonitrile, dichloromethane, dichloroethane, tetrahydrofuran or combinations thereof.

[0067] In another preferred ex...

Embodiment 1

[0107]

[0108] In a 500 mL reaction flask, compound I (1 equivalent), acetonitrile (8 volumes), and diisopropylethylamine (1.4 equivalents) were sequentially added. After the above mixture is stirred and lowered to -10 to -5 degrees Celsius, add sulfuryl fluoride balloons on the reaction bottle, and continue to react at a temperature of -10 to -5 degrees Celsius until the raw materials are no longer converted by HPLC (calculation of sulfuryl fluoride by balloon weight loss method). Fluorine consumption is about 1.3 equivalents). After the reaction mixture was concentrated to dryness under reduced pressure, 8 volumes of 25% isopropanol aqueous solution were added, the temperature was raised to 80°C and stirred for 3 hours, then cooled to 5-10°C, and filtered with suction to obtain the crude product of Florfenicol.

[0109] The crude product was heated and dissolved in 7 volumes of 30% isopropanol aqueous solution, then first cooled to 20-25°C, then cooled to 5-10°C and left...

Embodiment 2

[0111]

[0112]Get a 1000ml reaction kettle ready, equipped with a thermometer, add compound I (1 equivalent), dichloromethane (10 weights), diisopropylethylamine (1.2 equivalents) successively at room temperature, and control the temperature of the above mixture to 15 ~25 degrees Celsius, slowly introduce sulfuryl fluoride gas, the pressure is 2-3 atmospheres. Control the temperature at 15-25 degrees Celsius, react for 24 hours, and then concentrate the reaction mixture under reduced pressure to recover the solvent. Then add 8 volumes of 25% isopropanol aqueous solution into the reaction kettle, raise the temperature to 80-85 degrees Celsius, and stir for 3 hours. The reaction solution was cooled to 5-10 degrees Celsius and stirred for 1 hour. Suction filtration, the filter cake was washed with water and dried. Dry in a vacuum oven at 60-65°C for 16 hours to obtain a white solid, which meets the standards of the Pharmacopoeia of the People's Republic of China, with a yie...

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Abstract

The invention relates to a florfenicol synthesis method. The method comprises the step of carrying out a ring opening reaction on a product obtained by fluorinating a compound I by using sulfuryl fluoride as a fluorination reagent in a water-containing system to easily prepare florfenicol. The method has the advantages of simple operation, few by-products, safety, environmental protection, low production cost and the like, and is very suitable for industrial use.

Description

technical field [0001] The invention belongs to the field of medicine synthesis, and in particular relates to a synthesis method of florfenicol. Background technique [0002] Florfenicol (Florfenicol), also known as fluprofen, fluthiamphenicol, etc., is the 3-position fluorine derivative of thiamphenicol in chloramphenicol broad-spectrum antibacterial drugs, and is mainly used for animal disease prevention and treatment. Treatment of systemic infection in poultry and aquatic animals, etc. In recent years, the production and export of florfenicol in my country has been growing continuously, and it has been listed in the list of varieties of pharmaceutical raw materials with an annual export value of more than 100 million US dollars, attracting attention. [0003] The chemical name of Florfenicol is 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2- Base) acetamide, its chemical structural formula is as shown in the following formula: [0004] ...

Claims

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Application Information

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IPC IPC(8): C07C317/40C07C315/04C07D263/10C02F9/10C02F101/14C02F101/36C02F103/36
CPCC07C315/04C07D263/10C02F9/00C02F1/00C02F1/02C02F1/001C02F2101/14C02F2101/36C02F2103/343C02F2103/36C07C317/40C07C317/32
Inventor 朱文峰郭朋黄嘉慧
Owner SHANGHAI VASTPRO TECH DEV CO LTD
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