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Method for enhancing photostability of isoorientin and application

A technology of isoorientin and photostability, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of poor water solubility, prone to photolysis, unstable isoorientin, etc. , to achieve the effect of easy absorption, good biological safety, and enhanced photostability

Active Publication Date: 2020-11-27
SHAANXI NORMAL UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the above-mentioned problems that isoorientin is extremely unstable, prone to photolysis, and poor water solubility, etc., the present invention proposes a method and application for enhancing the photostability of isoorientin, and the isoorientin-silver The nanoparticle complex has good biological safety, can better inhibit the activity of α-glucosidase and pancreatic lipase, and has the effect of preventing diabetes and obesity. The specific technical scheme is as follows:

Method used

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  • Method for enhancing photostability of isoorientin and application
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  • Method for enhancing photostability of isoorientin and application

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preparation example Construction

[0031] The preparation method of isoorientin-silver nanoparticle composite comprises the following steps:

[0032] 1) Mix cornstarch aqueous solution, silver nitrate aqueous solution and sodium citrate aqueous solution according to the volume ratio of 20-60:50-99:3-8, react in a water bath and stir, centrifuge, and dry the precipitate after centrifugation obtaining silver nanoparticles;

[0033] 2) Disperse the silver nanoparticles in step 1) with ultrapure water, add them to the isorientin solution, stir in a water bath, then cool and centrifuge, and dry the centrifuged precipitate to obtain isorientin -Silver nanoparticles complex.

[0034] Preferably, the mass concentration of the corn starch aqueous solution is 1-3%, the molar concentration of the silver nitrate aqueous solution is 1-2 mM, and the molar concentration of the sodium citrate aqueous solution is 0.01-0.03 mol / L.

[0035] Preferably, the temperature of the water bath reaction in step 1) is 60-80°C.

[0036] ...

Embodiment 1

[0043] The preparation method of the isorientin-silver nanoparticle composite of the present embodiment, the steps are:

[0044] 1) The aqueous solution of cornstarch with a mass concentration of 2%, the aqueous silver nitrate solution with a molar concentration of 1.5mM, and the aqueous sodium citrate solution with a molar concentration of 0.02mol / L are mixed according to the ratio of 30:66:4 by volume, and mixed at 70 React in a water bath at ℃ and stir for 2 hours, centrifuge, and dry the precipitate after centrifugation to obtain silver nanoparticles;

[0045] 2) Disperse the silver nanoparticles prepared in step 1 with ultrapure water, add isoorientin solution with a volume of 6ml and a mass concentration of 1mg / mL, and stir for 30 hours in a water bath at 30°C. Centrifuge for 30 minutes, and dry the precipitate after centrifugation to obtain the isorientin-silver nanoparticle complex.

[0046] see figure 2 , the recombination rate of isoorientin-silver nanoparticle co...

Embodiment 2

[0048] The preparation method of the isorientin-silver nanoparticle composite of the present embodiment, the steps are:

[0049] 1) Mix an aqueous solution of cornstarch with a mass concentration of 1%, an aqueous solution of silver nitrate with a molar concentration of 1mM, and an aqueous solution of sodium citrate with a molar concentration of 0.01mol / L according to a ratio of 60:99:8 by volume, and heat at 60°C React in a water bath and stir for 1 hour, centrifuge, and dry the precipitate after centrifugation to obtain silver nanoparticles;

[0050] 2) Disperse the silver nanoparticles prepared in step 1 with ultrapure water, add isoorientin solution with a volume of 5ml and a mass concentration of 0.1mg / mL, and stir for 48 hours in a water bath at 20°C, at a speed of 8000rmp Centrifuge for 30 minutes, and dry the precipitate after centrifugation to obtain the isorientin-silver nanoparticle complex.

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Abstract

The invention provides a method for enhancing the light stability of isoorientin and application, and belongs to the technical field of chemical material performance improvement. The method is characterized in that: isoorientin is attached to the surfaces of silver nanoparticles to form the silver nanoparticles loaded with isoorientin, so that an isoorientin-silver nanoparticle compound is prepared. Compared with pure isoorientin, the photostability of the isoorientin-silver nanoparticle compound is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of performance improvement of chemical materials, and relates to the improvement of the performance of isorientin, in particular to a method and application for enhancing the light stability of isorientin. Background technique [0002] Isorientin, a tetrahydroxyflavone compound, is also known as 3',4',5,7-tetrahydroxyflavone-6-O-β-D-glucopyranoside or luteolin 6- C-glucoside, the molecular formula is C 21 h 2 OO 11 , the molecular weight is 448.38, and its chemical structure is as follows figure 1 shown. Isoorientin solid is a light yellow powder with a vapor density of 15.48 and a melting / freezing point of 237-239°C. It is widely found in cucumber, buckwheat, passion fruit and other foods, and has the functions of anti-oxidation, anti-inflammation, antibacterial, liver protection, and regulation of intestinal flora. However, due to the function of isoorientin itself, its application is limited, such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K31/352A61P3/10A61P3/04B22F9/24B82Y40/00
CPCA61K47/02A61K31/352A61P3/10A61P3/04B22F9/24B82Y40/00
Inventor 袁莉王晓李庆舒李浩
Owner SHAANXI NORMAL UNIV
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