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Biocompatible hydrogel compositions

A composition and hydrogel technology, applied in drug combination, gel preparation, colloid chemistry, etc., can solve the problems of limited practicability and efficacy, insufficient stability, and limited therapeutic efficacy

Pending Publication Date: 2020-11-27
巴西普罗梅顿医院医疗产品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In each case, the rapid breakdown of the biocompatible polymer gel limits the efficacy of the treatment and sometimes requires repeated infusions to produce significant results
Indeed, biocompatible polymer gels can be used in a wide variety of applications, but in many such cases, the insufficient stability of biocompatible polymer gels limits their utility and efficacy

Method used

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  • Biocompatible hydrogel compositions
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1: Determination of chondroitin 4-sulfate molecular weight (MW) by SDS-PAGE electrophoresis technique using polyacrylamide gel.

[0078] Used in "Polyacrylamide-gel electrophoresis and Alcian staining of sulphated glycosaminoglycan oligosaccharides", Mary K. Cowman, Mary F. Slahetka, Daniel M. Hittner, Jiyun Kim, Michael Forino and Geihan Gadelrab. Biochem. J. (1984) (221, 707-716) Polyacrylamide gel electrophoresis was performed as described in . An acrylamide solution containing 30% acrylamide and 0.8% NN'-methylenebisacrylamide was used and protected from light and stored at 4°C. Concentrated buffer at pH 8.6 containing 1.5M tris(hydroxymethyl)aminomethane / hydrogen chloride, also stored at 4°C, was used for the gel spacer. A solution of 0.5M tris(hydroxymethyl)aminomethane / hydrogen chloride at pH 6.8 was used for the concentrator gel. For polymerization, a solution of 50 μl and 70 μl of 10% (w / v) persulfate solution (prepared when used for the spacer gel) w...

Embodiment 2

[0083] Embodiment 2: the mensuration of polyquaternium-10 viscosity.

[0084] Polyquaternium-10 solutions (2%) in distilled water were prepared from which corresponding dilutions were made to obtain the following final concentrations: 0.5% (w / v); 1% (w / v), and 1.5 % (w / v). For these solutions, the viscosity was determined using a Brookfield viscometer, plate geometry (CP52) at 20°C and at different rotational speeds.

[0085] Table 1 shows the viscosity values ​​obtained from the different concentrations tested at different rotation speeds.

[0086]

[0087] Based on these test results, a sample of Polyquaternium-10 at a concentration (w / v) of 1% and 0.5 rpm had a viscosity of 2083 cp.

Embodiment 3

[0088]Embodiment 3: Preparation of the covalently crosslinked hydrogel reaction product of the crosslinking reaction of polyquaternium-10, chondroitin 4-sulfate, and divinyl sulfone, wherein the covalently crosslinked water The gel reaction product included 3% (w / v) of polyquaternium-10, 0.3% (w / v) of chondroitin 4-sulfate, and 3% (w / w) (based on polyquaternium- 10 and the total weight of chondroitin 4-sulfate) divinyl sulfone.

[0089] A 0.3 gram sample of polyquaternium-10 was dissolved in 7 ml of distilled water, and a 0.03 gram sample of chondroitin 4-sulfate was dissolved in 1.5 ml of distilled water. The two solutions were mixed for 5 minutes at room temperature with vigorous stirring to allow for electrostatic interactions between the two polymers. Then 1 ml of 0.5M NaOH solution was added to achieve a final concentration of 50 mM NaOH and a suitable pH. A 3% (w / v) dilution of divinyl sulfone in distilled water was added in an amount of 330 μl to the mixture, followed...

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Abstract

The present disclosure encompasses biocompatible hydrogel compositions comprising covalently bonded hydrogel reaction products, as well as compositions of, methods of producing, methods of using, andkits comprising the covalently cross-linked hydrogel reaction products. The covalently cross-linked hydrogel reaction products can be derived from a cross-linking reaction of a polyquaternium-10, a chondroitin 4-sulfate, and a divinylsulfone.

Description

technical field [0001] The present disclosure relates generally to biocompatible hydrogels, and more particularly to biocompatible hydraulic gels comprising the reaction product of a cationic cellulose-derived polymer covalently bonded to a naturally derived anionic polymer. Glue composition and its use and method of manufacture. Background technique [0002] Osteoarthritis is a disease involving the entire articulation of the joint. In damage to joint structures, changes in the properties of the synovial fluid can be observed. Several approaches to the treatment of osteoarthritis have been tried, from dietary supplements to viscosupplementary therapy using implantable corticoids and polymers and even surgical procedures. However, each attempted treatment has disadvantages that necessitate the need for further improvements. [0003] Implantation of biocompatible polymeric materials and gels to treat the condition often requires repeated and frequent infusions over time du...

Claims

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Application Information

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IPC IPC(8): B01J13/00A61L27/00
CPCA61L27/52B01J13/0052A61L2400/06A61L2400/10A61L2430/24A61K31/737A61P19/02C08L5/08A61K47/38A61K9/0024A61K47/6903C08J2301/02C08B15/005C08B15/06C08J3/246C08J3/075C08J2305/00C08B37/0069
Inventor K.比布劳尔R.V.阿拉西诺D.M.贝尔特拉莫O.N.格里古尔
Owner 巴西普罗梅顿医院医疗产品有限公司
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