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A kind of temozolomide magnetic thermosensitive liposome and preparation method thereof

A technology of temozolomide and temperature-sensitive lipid, which is applied in the field of nanomedicine to achieve the effects of convenient storage, avoiding poor stability and good dispersion

Active Publication Date: 2022-03-15
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although temozolomide has the advantages of oral administration and low toxicity, it is eliminated rapidly in the body, and its half-life in plasma is only 1.8h. To achieve effective drug concentration in cerebrospinal fluid, continuous high-dose administration is required

Method used

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  • A kind of temozolomide magnetic thermosensitive liposome and preparation method thereof
  • A kind of temozolomide magnetic thermosensitive liposome and preparation method thereof
  • A kind of temozolomide magnetic thermosensitive liposome and preparation method thereof

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Embodiment Construction

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0036] In describing the present invention, it is to be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "surrounding" etc. Indicating orientation or positional relationship is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a sp...

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Abstract

The invention discloses a temozolomide magnetic temperature-sensitive liposome, which relates to the field of nanomedicine. Firstly, a small molecule drug temozolomide (TMZ) and a liposome with a phase transition temperature are prepared into a solid precursor liposome, and then an ultra-small four-dimensional Ferric oxide magnetic nanoparticles (Fe 3 o 4 MNPs) suspension was hydrated to form Temozolomide Magnetic Thermosensitive Liposomes (TMZ / Fe‑TSL). This form of drug delivery combines ferrofluid hyperthermia, chemotherapy, and temperature-controlled drug release, which not only prolongs the plasma half-life of temozolomide, enhances its efficacy, but also reduces drug toxicity. The temozolomide magnetic temperature-sensitive liposome drug-carrying system provided by the present invention provides broad prospects for transformation and application for magnetic fluid hyperthermia combined with chemotherapy, and also provides a new scheme for the treatment and research of glioma.

Description

technical field [0001] The invention relates to the field of nanomedicine, in particular to a temozolomide magnetic temperature-sensitive liposome and a preparation method thereof. Background technique [0002] Brain tumors are a diverse group of neoplasms that originate in different cells of the central nervous system, and although rare, their incidence has been increasing over the past 50 years. According to statistics from the American Brain Tumor Registry, the incidence of primary brain and nervous system tumors in adults is about 27.9 / 100,000. Glioma accounts for about 40% of primary brain tumors, with an adult incidence rate of 6 / 100,000 and a 5-year survival rate of 20-30%. At present, surgery is the first choice for the treatment of gliomas. However, because gliomas mostly grow infiltratingly and have unclear boundaries with normal brain tissue, it is difficult to completely remove them by surgery, and recurrences often occur after surgery. As adjuvant therapy, che...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/00A61K47/10A61K47/24A61K31/4188A61K41/00A61P35/00C01G49/08
CPCA61K9/1277A61K9/0009A61K9/0004A61K47/10A61K47/24A61K31/4188A61K41/0052A61P35/00C01G49/08C01P2004/04A61K2300/00
Inventor 李云涛姚菁靑戴昕妤彭钢孟庆奇汤忠泉欧婷赵晓敏田雪黄柳戴悦
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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